Citation: BAO Aiqing, CHEN Huihua, LU Chunbo, ZHOU Wei, WANG Bin, CHEN Xiaolin, LIN Xianjun. Qualitative and quantitative analysis of unknown additives in sulfachlorpyrazine sodium soluble powder[J]. Chinese Journal of Chromatography, ;2017, 35(5): 520-525. doi: 10.3724/SP.J.1123.2016.12004 shu

Qualitative and quantitative analysis of unknown additives in sulfachlorpyrazine sodium soluble powder

Zhejiang Province Institute of Veterinary Drug and Feedstuff, Hangzhou 311101, China

Received Date: 4 December 2016

Fund Project: Special Fund for Agro-Scientific Research in the Public Interest (No. 201203023-4).

A qualitative and quantitative analysis of unknown additives in a batch of veterinary soluble sulfachlorpyrazine sodium powder had been implemented. The content of soluble sulfachlorpyrazine sodium powder was determined by potentiometric titration. The result showed that the titration was aberrant. According to the standard method, one of the two identifications was unqualified. It revealed that some unknown compounds may be doped in the sample. Then the screening of the sample through ultra high performance liquid chromatography coupled with quadrupole time-of-flight tandem mass pectrometry (UHPLC-Q/TOF MS) showed that the suspicious additives were found in the sample. Furthermore, double confirmation and content determination were accomplished by high performance liquid chromatography-diode array detection (HPLC-DAD). Mequindox and sulfadimidine as the illegal additives were detected at 40.3 and 16.4 mg/g respectively. By summarizing the above progress of deduction, validation and content determination, a good pattern was developed for screening illegal additives in veterinary drugs which provided a reference for the inspection of illegal adulterations in veterinary drugs.
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