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糖蛋白质组学中基于化学反应的富集方法研究进展

包慧敏 ,  谢力琦 ,  陆豪杰

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引用本文: 包慧敏,  谢力琦,  陆豪杰. 糖蛋白质组学中基于化学反应的富集方法研究进展[J]. 色谱, 2016, 34(12): 1145-1153. doi: 10.3724/SP.J.1123.2016.09003 shu
Citation:  BAO Huimin,  XIE Liqi,  LU Haojie. Research advances of enrichment approaches based on chemical reactions in glycoproteomics[J]. Chinese Journal of Chromatography, 2016, 34(12): 1145-1153. doi: 10.3724/SP.J.1123.2016.09003 shu

糖蛋白质组学中基于化学反应的富集方法研究进展

  • 复旦大学化学系, 生物医学研究院和老年医学研究中心 上海 200433

  • 基金项目:

    国家重点研发项目（2016YFA0501303）；国家自然科学基金（20905014，21335002）；上海市自然科学基金（14ZR1403600）；上海市老-医学临床重点实验室建设项目（13dz2260700）.

摘要: 蛋白质糖基化是一种广泛存在的重要的蛋白质翻译后修饰，糖基化肽在总酶解肽中占的比例不超过5%，这使得糖肽的分离富集成为糖蛋白质组学研究发展的关键技术之一。在诸多糖蛋白质组富集技术中，化学方法是富集技术的主导，本文从化学反应的角度介绍糖基化蛋白质富集的技术进展。富集过程按照连接和释放分别讨论，在连接过程中，重点介绍硼酸化学法、肼化学法、胺化学法和肟点击法；在释放过程中，以N-糖蛋白的酶释放法和O-糖蛋白的β-消除法为主导，一并介绍了最新的氧化断裂释放的化学法。最后，讨论总体富集策略的发展现状。该文以糖蛋白富集的共价反应为核心，分析不同方法的优缺点以及各技术在糖蛋白质组学研究中的应用和贡献。

English

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  • 收稿日期:  2016-09-01
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