Citation: MENG Xianshuang, MA Qiang, MA Longhua, CHEN Lihua, HAN Chao, BAI Hua, WU Qing. Rapid on-site screening of eight prohibited antibiotics in cosmetics using extraction nano-electrospray coupled with ion mobility spectrometry[J]. Chinese Journal of Chromatography, ;2016, 34(6): 596-601. doi: 10.3724/SP.J.1123.2016.03019 shu

Rapid on-site screening of eight prohibited antibiotics in cosmetics using extraction nano-electrospray coupled with ion mobility spectrometry

MENG Xianshuang ¹ ,
MA Qiang ^1,*,, ,
MA Longhua ² ,
CHEN Lihua ³ ,
HAN Chao ⁴ ,
BAI Hua ¹ ,
WU Qing ²

1.
Chinese Academy of Inspection and Quarantine, Beijing 100176, China
2.
Excellims Corporation, Acton, MA 01720, USA
3.
Chongqing Entry-Exit Inspection and Quarantine Bureau, Chongqing 400020, China
4.
Wenzhou Entry-Exit Inspection and Quarantine Bureau, Wenzhou 325027, China

Corresponding author: MA Qiang, maqiang@caiq.gov.cn
Received Date: 15 March 2016

Fund Project: Science Research Program of General Administration of Quality Supervision, Inspection and Quarantine of China 2015IK314Basic Research Fund for Central Public Interest Institutes 2016JK004

A rapid on-site method has been developed for the identification of eight prohibited antibiotics in cosmetics using extraction nano-electrospray coupled with ion mobility spectrometry. The experimental conditions for capillary pulling, extraction nano-electrospray, and ion mobility spectrometry were investigated and optimized. Under the optimum conditions, the limits of detection (LODs) for the eight prohibited antibiotics were 20 mg/kg. The instrumental analysis time for a single ion mobility spectrometry run was less than 20 ms, and the total period for sample analysis was less than 30 s. The suspicious positive samples were subjected to further verification by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). The proposed method is rapid, efficient with greatly simplified work flows and can provide potential analytical possibility for outside-the-lab screening of cosmetics for the presence of illicit ingredients.
- extraction nano-electrospray,
- ion mobility spectrometry (IMS),
- prohibited antibiotics,
- cosmetics,
- rapid on-site screening
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