Citation: WU Chunying, GU Feng, BAI Lu, LU Wenlong. Simultaneous determination of 22 typical pharmaceuticals and personal care products in environmental water using ultra performance liquid chromatography- triple quadrupole mass spectrometry[J]. Chinese Journal of Chromatography, ;2015, 33(8): 843-848. doi: 10.3724/SP.J.1123.2015.04019 shu

Simultaneous determination of 22 typical pharmaceuticals and personal care products in environmental water using ultra performance liquid chromatography- triple quadrupole mass spectrometry

WU Chunying ^1,2,, ,
GU Feng ¹ ,
BAI Lu ¹ ,
LU Wenlong ¹

1.
1. School of Resources and Environmental Engineering, Jilin Institute of Chemical Technology, Jilin 132022, China;

Corresponding author: WU Chunying,
Received Date: 13 April 2015

Fund Project: 中国博士后科学基金项目(20080440374). (20080440374)

An analytical method for simultaneous determination of 22 typical pharmaceuticals and personal care products (PPCPs) in environmental water samples was developed by ultra performance liquid chromatography-triple quadrupole mass spectrometry (UPLC-MS/MS). An Oasis HLB solid phase extraction cartridge, methanol as washing solution, water containing 0.1% formic acid-methanol (7:3, v/v) as the mobile phases were selected for sample pretreatment and chromatographic separation. Based on the optimized sample pretreatment procedures and separation condition, the target recoveries ranged from 73% to 125% in water with the relative standard deviations (RSDs) from 8.8% to 17.5%, and the linear ranges were from 2 to 2000 μg/L with correlation coefficients (R²) not less than 0.997. The method can be applied to simultaneous determination of the 22 typical PPCPs in environmental water samples because of its low detection limits and high recoveries. It can provide support and help for the related research on water environmental risk assessment and control of the micro-organic pollutants.
1. [1]
  [1] EPA. Protecting Human Health, Safeguarding the Natural Environment. (1999-12-24)[2005-03-20]. http://www.epa.gov/nerl/research/1999/html/g8-14.html
2. [2]
  [2] Zhao X, Chen Z L, Wang X C, et al. Bioresource Technol, 2015, 179: 104
3. [3]
  [3] Carballa M, Omil F, Lema J M, et al. Water Res, 2004, 38(12): 2918
4. [4]
  [4] Huang C L, Ma H W, Yu C P. Sci Total Environ, 2014, 499(15): 265
5. [5]
  [5] Jia Y Y, Tan J H, Xu C, et al. Chinese Journal of Chromatography (贾妍艳, 谭建华, 徐晨, 等. 色谱), 2014, 32(3): 263
6. [6]
  [6] Zhu S C, Wang J, Shao W W, et al. Chinese Journal of Chromatography (朱赛嫦, 王静, 邵卫伟, 等. 色谱), 2013, 31(1): 15
7. [7]
  [7] Kong L X, Kadokami K, Wang S P, et al. Chemosphere, 2015, 122: 125
8. [8]
  [8] Blair B D, Crago J P, Hedman C J, et al. Chemosphere, 2013, 93(9): 2116
9. [9]
  [9] Kasprzyk-Hordern B, Dinsdale R M, Guwy A J. J Chromatogr A, 2007, 1161(1/2): 132
10. [10]
  [10] Cerqueira M B R, Guilherme J R, Caldas S S, et al. Chemosphere, 2014, 107: 74
11. [11]
  [11] Kuroda K, Nakada N, Hanamoto S, et al. Sci Total Environ, 2015, 506/507: 287
12. [12]
  [12] Jia X X. [MS Dissertation]. Xi'an: Xi'an University of Architecture and Technology (贾翔宵. [硕士学位论文]. 西安: 西安建筑科技大学), 2010
13. [13]
  [13] Zhou H D. [Postdoctoral Research Report]. Beijing: Tsinghua University (周海东. [博士后研究报告]. 北京: 清华大学), 2009
14. [14]
  [14] Yan Z, Nie J Y, Xu G F, et al. Journal of Instrumental Analysis (闫震, 聂继云, 徐国锋, 等. 分析测试学报), 2014, 33(9): 1000
15. [15]
  [15] Zhang P W, Zhao G F, Zhou H D, et al. Environmental Monitoring of China (张盼伟, 赵高峰, 周怀东, 等. 中国环境监测), 2014, 30(1): 138
16. [16]
  [16] Gao H, Zu G R, Gu J, et al. Chinese Journal of Analysis Laboratory (高会, 祖国仁, 顾佳, 等. 分析试验室), 2011, 30(12): 8
17. [17]
  [17] Qiu Y Q, Chen G Q, Lei Y, et al. Physical Testing and Chemical Analysis Part B: Chemical Analysis (邱蕴绮, 陈国权, 雷毅, 等. 理化检验-化学分册), 2014, 50(6): 57
1. [1]
  Siwei Hou , Yaxin Niu , Guanglu Zhang , Yanmei Yang , Xu Wang , Zhenzhen Chen . Application of Solid-Phase Microextraction and Mass Spectrometry in Environmental Detection. University Chemistry, 2026, 41(3): 297-306. doi: 10.12461/PKU.DXHX202504078
2. [2]
  Yanhui Zhong , Ran Wang , Zian Lin . Analysis of Halogenated Quinone Compounds in Environmental Water by Dispersive Solid-Phase Extraction with Liquid Chromatography-Triple Quadrupole Mass Spectrometry. University Chemistry, 2024, 39(11): 296-303. doi: 10.12461/PKU.DXHX202402017
3. [3]
  Zunxiang Zeng , Yuling Hu , Yufei Hu , Hua Xiao . Analysis of Plant Essential Oils by Supercritical CO₂Extraction with Gas Chromatography-Mass Spectrometry: An Instrumental Analysis Comprehensive Experiment Teaching Reform. University Chemistry, 2024, 39(3): 274-282. doi: 10.3866/PKU.DXHX202309069
4. [4]
  Haiyuan Wang , Xiaoning Jin , Yajing Sun , Zhen Zhang , Wentao Zhao , Yi Li . Practical Exploration of High-Performance Liquid Chromatography Experiment Teaching Reform Empowered by Artificial Intelligence. University Chemistry, 2026, 41(4): 45-51. doi: 10.12461/PKU.DXHX202505076
5. [5]
  Yifan Xie , Liyun Yao , Ruolin Yang , Yuxing Cai , Yujie Jin , Ning Li . Exploration and Practice of Online and Offline Hybrid Teaching Mode in High-Performance Liquid Chromatography Experiment. University Chemistry, 2025, 40(11): 100-107. doi: 10.12461/PKU.DXHX202412133
6. [6]
  Ke Qiu , Fengmei Wang , Mochou Liao , Kerun Zhu , Jiawei Chen , Wei Zhang , Yongyao Xia , Xiaoli Dong , Fei Wang . A Fumed SiO₂-based Composite Hydrogel Polymer Electrolyte for Near-Neutral Zinc-Air Batteries. Acta Physico-Chimica Sinica, 2024, 40(3): 2304036-0. doi: 10.3866/PKU.WHXB202304036
7. [7]
  Haifeng Liu , Yong Xiao , Teng Yuan , Bimin Lin , Yizhen Wang , Hui Zeng . Exploration of Safety Facility Configuration in University Chemical Depot. University Chemistry, 2024, 39(10): 182-188. doi: 10.3866/PKU.DXHX202401036
8. [8]
  Mingyang Men , Jinghua Wu , Gaozhan Liu , Jing Zhang , Nini Zhang , Xiayin Yao . Sulfide Solid Electrolyte Synthesized by Liquid Phase Approach and Application in All-Solid-State Lithium Batteries. Acta Physico-Chimica Sinica, 2025, 41(1): 100004-0. doi: 10.3866/PKU.WHXB202309019
9. [9]
  Chongjing Liu , Yujian Xia , Pengjun Zhang , Shiqiang Wei , Dengfeng Cao , Beibei Sheng , Yongheng Chu , Shuangming Chen , Li Song , Xiaosong Liu . Understanding Solid-Gas and Solid-Liquid Interfaces through Near Ambient Pressure X-Ray Photoelectron Spectroscopy. Acta Physico-Chimica Sinica, 2025, 41(2): 100013-0. doi: 10.3866/PKU.WHXB202309036
10. [10]
  Runjie Li , Hang Liu , Xisheng Wang , Wanqun Zhang , Wanqun Hu , Kaiping Yang , Qiang Zhou , Si Liu , Pingping Zhu , Wei Shao . 氨基酸的衍生及手性气相色谱分离创新实验. University Chemistry, 2025, 40(6): 286-295. doi: 10.12461/PKU.DXHX202407059
11. [11]
  Ranhui Fu , Shixin Zhou , Ran Ji , Feifei Gao , Hui Xu . 季膦盐合成实验的改进与拓展——水相一步法合成乙基三苯基溴化膦及其力致发光锰配合物的制备及表征. University Chemistry, 2026, 41(5): 252-263. doi: 10.12461/PKU.DXHX202510018
12. [12]
  Gaoyan Chen , Chaoyue Wang , Juanjuan Gao , Junke Wang , Yingxiao Zong , Kin Shing Chan . Heart to Heart: Exploring Cardiac CT. University Chemistry, 2024, 39(9): 146-150. doi: 10.12461/PKU.DXHX202402011
13. [13]
  Shunü Peng , Huamin Li , Zhaobin Chen , Yiru Wang . Simultaneous Application of Multiple Quantitative Analysis Methods in Gas Chromatography for the Determination of Active Ingredients in Traditional Chinese Medicine Preparations. University Chemistry, 2025, 40(10): 243-249. doi: 10.12461/PKU.DXHX202412043
14. [14]
  Zongyuan Chen , ChunSheng Shi , Yiwen Li , Ganlin Zu , Qiang Jin , Haishan Wang , Fujun Wang , Dekun Yan , Zhijun Guo , Wangsuo Wu . Measurement of Uranium Isotopes in Environmental Water Samples by Alpha-Spectroscopy: Design of an Undergraduate Radiochemistry Experiment. University Chemistry, 2025, 40(4): 353-358. doi: 10.12461/PKU.DXHX202406103
15. [15]
  Yajie Li , Bin Chen , Yiping Wang , Hui Xing , Wei Zhao , Geng Zhang , Siqi Shi . Inhibiting Dendrite Growth by Customizing Electrolyte or Separator to Achieve Anisotropic Lithium-Ion Transport: A Phase-Field Study. Acta Physico-Chimica Sinica, 2024, 40(3): 2305053-0. doi: 10.3866/PKU.WHXB202305053
16. [16]
  Chunai Dai , Yongsheng Han , Luting Yan , Zhen Li , Yingze Cao . Ideological and Political Design of Solid-liquid Contact Angle Measurement Experiment. University Chemistry, 2024, 39(2): 28-33. doi: 10.3866/PKU.DXHX202306065
17. [17]
  Xiaowu Zhang , Pai Liu , Qishen Huang , Shufeng Pang , Zhiming Gao , Yunhong Zhang . Acid-Base Dissociation Equilibrium in Multiphase System: Effect of Gas. University Chemistry, 2024, 39(4): 387-394. doi: 10.3866/PKU.DXHX202310021
18. [18]
  Binbin Liu , Yang Chen , Tianci Jia , Chen Chen , Zhanghao Wu , Yuhui Liu , Yuhang Zhai , Tianshu Ma , Changlei Wang . Hydroxyl-functionalized molecular engineering mitigates 2D phase barriers for efficient wide-bandgap and all-perovskite tandem solar cells. Acta Physico-Chimica Sinica, 2026, 42(1): 100128-0. doi: 10.1016/j.actphy.2025.100128
19. [19]
  Jiayao Wang , Guixu Pan , Ning Wang , Shihan Wang , Yaolin Zhu , Yunfeng Li . Preparation of donor-π-acceptor type graphitic carbon nitride photocatalytic systems via molecular level regulation for high-efficient H₂O₂ production. Acta Physico-Chimica Sinica, 2025, 41(12): 100168-0. doi: 10.1016/j.actphy.2025.100168
20. [20]
  Zhaoxuan ZHU , Lixin WANG , Xiaoning TANG , Long LI , Yan SHI , Jiaojing SHAO . Application of poly(vinyl alcohol) conductive hydrogel electrolytes in zinc ion batteries. Chinese Journal of Inorganic Chemistry, 2025, 41(5): 893-902. doi: 10.11862/CJIC.20240368

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(642)
HTML views(24)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142