Citation: CHEN Fangfang, SHI Yanping. Application of molecularly imprinted solid phase extraction in the separation and determination of active constituents from natural compounds[J]. Chinese Journal of Chromatography, ;2013, 31(7): 626-633. doi: 10.3724/SP.J.1123.2013.05026 shu

Application of molecularly imprinted solid phase extraction in the separation and determination of active constituents from natural compounds

CHEN Fangfang ^1,2 ,
SHI Yanping ^1,,

1.
1. Key Laboratory of Chemistry of Northwestern Plant Resources, CAS/Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China;

Corresponding author: SHI Yanping,
Received Date: 17 May 2013

Fund Project: 国家自然科学基金项目(21075127,20875095). (21075127,20875095)

The active constituents of natural medicine resources are complicated and in low content, which are difficult to be extracted and separated by general methods. Molecularly imprinted polymers are functional porous materials with molecular-specific recognition sites to a particular target molecule. The molecularly imprinted solid phase extraction has been used as a sample preparation technique for the separation of active constituents from natural medicine resources. The target molecules in a mixture of chemical species can be recognized selectively. In this review, the applications of the molecularly imprinted solid phase extraction for the determination and separation of active constituents (e.g. flavonoids, polyphenols, alkaloids, organic acids, phenylpropanoids, terpenoids, etc.) from natural compounds in recent years are summarized.
- molecularly imprinted solid phase extraction,
- natural medicine resources,
- natural products,
- separation and determination,
- review
1. [1]
  [1] Sellergren B. Anal Chem, 1994, 66(9): 1578
2. [2]
  [2] Zheng C, Huang Y P, Liu Z S. Anal Bioanal Chem, 2013, 405(7): 2147
3. [3]
  [3] Sergeyeva T A, Slinchenko O A, Gorbach L A, et al. Anal Chim Acta, 2010, 659(1/2): 274
4. [4]
  [4] Fang G Z, Lu J P, Pan M F, et al. Food Anal Meth, 2011, 4(4): 590
5. [5]
  [5] Dickert F L, Thierer S. Adv Mater, 1996, 8(12): 987
6. [6]
  [6] Haupt K. Anal Chem, 2003, 75(17): 376http://www.utc.fr/~wmpi/index.php?option=com_content&view=article&id=13&Itemid=17
7. [7]
  [7] Ansell R J, Mosbach K. J Chromatogr A, 1997, 787(1/2): 55http://www.progchem.ac.cn/CN/abstract/abstract8639.shtml
8. [8]
  [8] Cheli W, Fen M A, Haiyan Z, et al. Fine Chem, 2007, 24(8): 729
9. [9]
  [9] Zhang Y F, Qi C, Mei F, et al. Chinese Journal of Applied Chemistry (张艳芳, 祁超, 梅芳, 等. 应用化学), 2009, 26(7): 786http://www.cnki.com.cn/Journal/B-B1-YYHX-2009-07.htm
10. [10]
  [10] Khodadadian M, Ahmadi F. Talanta, 2010, 81(4/5): 1446
11. [11]
  [11] Zhu L L, Xu X J. J Chromatogr A, 2003, 991(2): 151
12. [12]
  [12] Zhou J, He X W, Li Y J. Anal Commun, 1999, 36(6): 243
13. [13]
  [13] Ramstrom O, Andersson L I, Mosbach K. J Org Chem, 1993, 58(26): 7562
14. [14]
  [14] Yu C, Mosbach K. J Chromatogr A, 2000, 888(1/2): 63
15. [15]
  [15] Jiang T H, Zhao L X, Chu B L, et al. Talanta, 2009, 78(2): 442
16. [16]
  [16] Muhammad T, Nur Z, Piletska E V, et al. Analyst, 2012, 137(11): 2623
17. [17]
  [17] Haupt K, Dzgoev A, Mosbach K. Anal Chem, 1998, 70(3): 628
18. [18]
  [18] Fu X W, Wu Y J, Qu J R, et al. Environ Monit Assess, 2012, 184(7): 4161
19. [19]
  [19] Asanuma H, Akiyama T, Kajiya K, et al. Anal Chim Acta, 2001, 435(1): 25
20. [20]
  [20] Haginaka J, Takehira H, Hosoya K, et al. J Chromatogr A, 1998, 816(2): 113
21. [21]
  [21] Yoshida M, Uezu K, Goto M, et al. J Appl Poly Sci, 1999, 73(7): 1223
22. [22]
  [22] Luo X, Deng F, Luo S, et al. J Appl Poly Sci, 2011, 121(4): 1930
23. [23]
  [23] Zhou X, Li H J. Chinese Journal of New Drugs (周新, 李宏杰. 中国新药杂志), 2007, 16(5): 350
24. [24]
  [24] Molinelli A, Weiss R, Mizaikoff B. J Agric Food Chem, 2002, 50(7): 1804
25. [25]
  [25] Yan L S, Jing J, Huang Z M, et al. Chinese Journal of Analysis Laboratory (颜流水, 井晶, 黄智敏, 等. 分析试验室), 2006, 25(5): 97http://www.redlib.cn/qikan/6724/200605.htm
26. [26]
  [26] Song X, Li J, Wang J, et al. Talanta, 2009, 80(2): 694
27. [27]
  [27] Pakade V, Lindahl S, Chimuka L, et al. J Chromatogr A, 2012, 1230: 15
28. [28]
  [28] Xie J C, Chen L R, Li C X, et al. J Chromatogr B, 2003, 788(2): 233
29. [29]
  [29] Weiss R, Molinelli A, Jakusch M, et al. Bioseparation, 2001, 10(6): 379
30. [30]
  [30] López M del M C, Pérez M C C, García M S D, et al. Anal Chim Acta, 2012, 721: 68
31. [31]
  [31] Xie J C, Zhu L L, Luo H P, et al. J Chromatogr A, 2001, 934(1/2): 1
32. [32]
  [32] Pakade V, Cukrowska E, Lindahl S, et al. J Sep Sci, 2013, 36(3): 548
33. [33]
  [33] Peng L, Wang Y, Zeng H, et al. Analyst, 2011, 136(4): 756
34. [34]
  [34] Theodoridis G, Lasakova M, Skerikova V, et al. J Sep Sci, 2006, 29(15): 2310
35. [35]
  [35] Li L, Hu S G, He X W, et al. Chemical Journal of Chinese Universities-Chinese (李礼, 胡树国, 何锡文, 等. 高等学校化学学报), 2006, 27(4): 608http://www.cjcu.jlu.edu.cn/CN/abstract/abstract12441.shtml
36. [36]
  [36] Chen L N, Du S H, Ma K F, et al. Chemistry and Industry of Forest Products (陈立娜, 都述虎, 马坤芳, 等. 林产化学与工业), 2008, 28(3): 18http://www.redlib.cn/qikan/8390/200803.htm
37. [37]
  [37] Chen L, Jia X, Lu Q, et al. Sep Purif Technol, 2010, 71(3): 324
38. [38]
  [38] Luo J, Zhang L, Chen D, et al. Analyst, 2012, 137(12): 2891
39. [39]
  [39] Yan H, Tian M, Row K H. Sep Sci Technol, 2009, 44(2): 359
40. [40]
  [40] Zhu H, Wang Y, Yuan Y, et al. Anal Meth, 2011, 3(2): 348
41. [41]
  [41] Xiao S J, Li H X, Yu S W. Chemical Industry and Engineering Progress (肖淑娟, 李红霞, 于守武. 化工进展), 2010, 29(2): 293http://www.cnki.com.cn/Journal/B-B2-HGJZ-2010.htm
42. [42]
  [42] Zhang Z, Liu L, Li H, et al. Appl Surf Sci, 2009, 255(23): 9327
43. [43]
  [43] Zhang M L, Zhang Z H, Liu L, et al. Chinese Journal of Analytical Chemistry (张明磊, 张朝晖, 刘丽, 等. 分析化学), 2010, 38(1): 129http://wuxizazhi.cnki.net/Magazine/FXHX201001.html
44. [44]
  [44] Schwarz L J, Danylec B, Yang Y, et al. J Agric Food Chem, 2011, 59(8): 3539
45. [45]
  [45] Euterpio M A, Pagano I, Piccinelli A L, et al. J Agric Food Chem, 2013, 61(8): 1640
46. [46]
  [46] Zhong S A, He G W, Lei Q F, et al. Chinese Journal of Analysis Laboratory (钟世安, 贺国文, 雷启福, 等. 分析试验室), 2007, 26(10): 1http://www.cnki.com.cn/Journal/B-B1-FXSY-2007-10.htm
47. [47]
  [47] Blahova E, Lehotay J, Skacani I. J Liq Chromatogr R T, 2004, 27(17): 2715
48. [48]
  [48] Blahova E, Lehotay J. Chem Anal, 2006, 51(5): 795
49. [49]
  [49] Ding L, Li H, Tang F, et al. Anal Lett, 2006, 39(12): 2373
50. [50]
  [50] Xiang H, Fan Y, Li M, et al. J Instru Anal, 2013, 32(1): 45
51. [51]
  [51] Puoci F, Cirillo G, Curcio M, et al. Anal Chim Acta, 2007, 593(2): 164
52. [52]
  [52] Lopez C, Claude B, Morin P, et al. Anal Chim Acta, 2011, 683(2): 198
53. [53]
  [53] Dong X C, Wei W A, Ma S J, et al. J Chromatogr A, 2005, 1070(1/2): 125
54. [54]
  [54] Chen C Y, Wang C H, Chen A H. Talanta, 2011, 84(4): 1038
55. [55]
  [55] Zhu Q, Huang D, Li L, et al. Sci China-Chem, 2010, 53(12): 2587
56. [56]
  [56] Theodoridis G, Manesiotis P. J Chromatogr A, 2002, 948(1/2): 163
57. [57]
  [57] Farrington K, Magner E, Regan F. Anal Chim Acta, 2006, 566(1): 60
58. [58]
  [58] Jin Y Z, Row K H. J Ind Engi Chem, 2006, 12(3): 494
59. [59]
  [59] Wei S L, Guo X J, Wang H W, et al. Chinese Journal of Analytical Chemistry (韦寿莲, 郭小君, 汪洪武, 等. 分析化学), 2012, 40(7): 1071http://www.cnki.com.cn/Journal/B-B1-FXHX-2012-07.htm
60. [60]
  [60] Lai J P, He X W, Jiang Y, et al. Anal Bioanal Chem, 2003, 375(2): 264
61. [61]
  [61] Guo Z, Zhang L, Song C, et al. Analyst, 2011, 136(14): 3016
62. [62]
  [62] Mullett W M, Lai E P C, Sellergren B. Anal Commun, 1999, 36(6): 217
63. [63]
  [63] Theodoridis G, Kantifes A, Manesiotis P, et al. J Chromatogr A, 2003, 987(1/2): 103
64. [64]
  [64] Nakamura M, Ono M, Nakajima T, et al. J Pharm Biomed Anal, 2005, 37(2): 231
65. [65]
  [65] Lin L Q, Zhang J, Fu Q, et al. Anal Chim Acta, 2006, 561(1/2): 178
66. [66]
  [66] Wang G, Cao Q, Zhu X, et al. J Appl Poly Sci, 2009, 113(5): 3049
67. [67]
  [67] Xie B X, Sun Z D. Modern Food Science and Technology (谢碧秀, 孙智达. 现代食品科技), 2007, 23(9): 93http://www.redlib.cn/qikan/4665/200709.htm
68. [68]
  [68] Zhang H B, Zhang Z H, Nie Y, et al. Chinese Journal of Analytical Chemistry (张华斌, 张朝晖, 聂燕, 等. 分析化学), 2009, 37(7): 955http://journal.9med.net/html/qikan/jcyxyswyxgc/fxhxyxqkx/20101101/yjjb/20100303103859966_511915.html
69. [69]
  [69] Karasova G, Lehotay J, Sadecka J, et al. J Sep Sci, 2005, 28(18): 2468
70. [70]
  [70] Chen F F, Wang G Y, Shi Y P. J Sep Sci, 2011, 34(19): 2602
71. [71]
  [71] Li N, Ng T B, Wong J H, et al. Food Chem, 2013, 139(1/4): 1161
72. [72]
  [72] Zhu T, Li S, Row K H. J Appl Poly Sci, 2011, 121(3): 1691
73. [73]
  [73] Yuan X, Xu X, Zhu W, et al. Chinese Pharmaceutical Journal (袁小红, 徐筱杰, 朱伟, 等. 中国药学杂志), 2010, 45(8): 574http://www.zgyxzz.com.cn/CN/volumn/volumn_1972_abs.shtml
74. [74]
  [74] Yuan Y, Wang Y Z, Huang M D, et al. Anal Chim Acta, 2011, 695(1/2): 63
75. [75]
  [75] Zhu X F, Cao Q, Hou N B, et al. Anal Chim Acta, 2006, 561(1/2): 171
76. [76]
  [76] Hu S G, Li L, He X W. J Chromatogr A, 2005, 1062(1): 31
77. [77]
  [77] Wang G S, Cao Q E, Ding Z T, et al. Helv Chim Acta, 2007, 90(6): 1179
78. [78]
  [78] Bi J, liu M, Lin W H, et al. Chinese Traditional and Herbal Drugs (毕娟, 刘淼, 林文翰, 等. 中草药), 2005, 36(6): 866http://med.wanfangdata.com.cn/Author/General/Detail.aspx?id=A000552086
79. [79]
  [79] Chen F F, Wang R, Shi Y P. Talanta, 2012, 89: 505
80. [80]
  [80] Gong X Y, Cao X J. J Biotechnol, 2011, 153(1/2): 8
81. [81]
  [81] Xie J, Cai C, Yang H, et al. Anal Lett, 2013, 46(1): 107
82. [82]
  [82] Jiang Y F, Li J J, Zhong Y Q, et al. Chinese Pharmaceutical Journal (江一帆, 李进进, 衷友泉, 等. 中国药学杂志), 2012, 47(13): 1077http://med.wanfangdata.com.cn/Author/General/Detail.aspx?id=A000980568
83. [83]
  [83] Claude B, Morin P, Lafosse M, et al. Talanta, 2008, 75(2): 344
84. [84]
  [84] Liu H, Liu C, Yang X, et al. J Sep Sci, 2008, 31(20): 3573
85. [85]
  [85] Cirillo G, Curcio M, Parisi O I, et al. Food Chem, 2011, 125(3): 1058
86. [86]
  [86] Hrobonova K, Spevak A, Spisska L U, et al. Chem Pap, 2013, 67(5): 477
87. [87]
  [87] Yin X, Liu Q, Jiang Y, et al. Spectrochim Acta A, 2011, 79(1): 191
88. [88]
  [88] Chen X, Zhang Z, Yang X, et al. Talanta, 2012, 99: 959
89. [89]
  [89] Chen X, Zhang Z, Yang X, et al. J Sep Sci, 2012, 35(18): 2414
90. [90]
  [90] Yan H, Tian M, Row K H. Chin J Chem, 2009, 27(11): 2212
91. [91]
  [91] Tian M, Bi W, Row K H. Anal Bioanal Chem, 2011, 399(7): 2495
92. [92]
  [92] Jia X, Li H, Luo J, et al. Anal Bioanal Chem, 2012, 403(9): 2691
93. [93]
  [93] Guo Z F, Guo T T, Guo M. Anal Chim Acta, 2008, 612(2): 136
94. [94]
  [94] Mohajeri S A, Hosseinzadeh H, Keyhanfar F, et al. J Sep Sci, 2010, 33(15): 2302
95. [95]
  [95] Zhu Q, Wang L, Wu S, et al. Food Chem, 2009, 113(2): 608
96. [96]
  [96] Zhu T, Yoon C, Row K. Chin J Chem, 2011, 29(6): 1246
97. [97]
  [97] Piletska E V, Burns R, Terry L A, et al. J Agric Food Chem, 2012, 60(1): 95
98. [98]
  [98] Lachova M, Lehotay J, Karasova G, et al. J Liq Chromatogr R T, 2007, 30(13/14/15/16): 2045
1. [1]
  Ying Chen , Ronghua Yan , Weiyan Yin . Research Progress on the Synthesis of Metal Single-Atom Catalysts and Their Applications in Electrocatalytic Hydrogen Evolution Reactions. University Chemistry, 2025, 40(9): 344-353. doi: 10.12461/PKU.DXHX202503066
2. [2]
  Tao Yang , Kaijiao Duan , Siyu Li , Jing Wei , Qingdi Yang , Qian Wang . A Comprehensive and Innovative Chemical Experimental Teaching: Extraction and Identification of Tea Polyphenols from Pu'er Tea and the Application in Hand Cream Making. University Chemistry, 2024, 39(8): 270-275. doi: 10.3866/PKU.DXHX202312040
3. [3]
  Xianjiao Meng , Yujiao Ma , Wang Li , Xi Zhao , Yiming Wang , Fugui Wang , Yongpo Zhang , Jinzhong Zhao . Experimental Teaching Design of Extracting Capsanthin from Chili Peppers: A Digital Perspective. University Chemistry, 2025, 40(11): 233-240. doi: 10.12461/PKU.DXHX202412118
4. [4]
  Leqin He , Yunhan Qin , Jing Wang , Yukuan Zhang , Zhengping Dong , Shuai Han . Tea’s Colorful Chemistry: A Popular Science Experiment Featuring Tea Polyphenols. University Chemistry, 2026, 41(2): 255-262. doi: 10.12461/PKU.DXHX202502068
5. [5]
  Lijuan Wang , Yuping Ning , Sha Luo . A green approach to natural products chemistry experiments: optimization and improvement of berberine hydrochloride preparation. University Chemistry, 2026, 41(4): 424-432. doi: 10.12461/PKU.DXHX202503120
6. [6]
  Yanhui Zhong , Ran Wang , Zian Lin . Analysis of Halogenated Quinone Compounds in Environmental Water by Dispersive Solid-Phase Extraction with Liquid Chromatography-Triple Quadrupole Mass Spectrometry. University Chemistry, 2024, 39(11): 296-303. doi: 10.12461/PKU.DXHX202402017
7. [7]
  Lijuan Wang , Yuping Ning , Jian Li , Sha Luo , Xiongfei Luo , Ruiwen Wang . Enhancing the Advanced Nature of Natural Product Chemistry Laboratory Courses with New Research Findings: A Case Study of the Application of Berberine Hydrochloride in Photodynamic Antimicrobial Films. University Chemistry, 2024, 39(11): 241-250. doi: 10.12461/PKU.DXHX202403017
8. [8]
  Yuxia Luo , Xiaoyu Xie , Fangfang Chen . 药物递送魔法师——分子印迹聚合物. University Chemistry, 2025, 40(8): 202-210. doi: 10.12461/PKU.DXHX202409129
9. [9]
  Zihan Lin , Wanzhen Lin , Fa-Jie Chen . Electrochemical Modifications of Native Peptides. University Chemistry, 2025, 40(3): 318-327. doi: 10.12461/PKU.DXHX202406089
10. [10]
  Peihong Fan , Hongxiang Lou . 研究生高等天然药物化学课程的教学改革探索——导学互促式混合课堂教学与自主学习能力培养. University Chemistry, 2025, 40(6): 16-21. doi: 10.12461/PKU.DXHX202407078
11. [11]
  Siwei Hou , Yaxin Niu , Guanglu Zhang , Yanmei Yang , Xu Wang , Zhenzhen Chen . Application of Solid-Phase Microextraction and Mass Spectrometry in Environmental Detection. University Chemistry, 2026, 41(3): 297-306. doi: 10.12461/PKU.DXHX202504078
12. [12]
  Junjie Zhang , Yue Wang , Qiuhan Wu , Ruquan Shen , Han Liu , Xinhua Duan . Preparation and Selective Separation of Lightweight Magnetic Molecularly Imprinted Polymers for Trace Tetracycline Detection in Milk. University Chemistry, 2024, 39(5): 251-257. doi: 10.3866/PKU.DXHX202311084
13. [13]
  Zunxiang Zeng , Yuling Hu , Yufei Hu , Hua Xiao . Analysis of Plant Essential Oils by Supercritical CO₂Extraction with Gas Chromatography-Mass Spectrometry: An Instrumental Analysis Comprehensive Experiment Teaching Reform. University Chemistry, 2024, 39(3): 274-282. doi: 10.3866/PKU.DXHX202309069
14. [14]
  Yiru Wang , Chanzi Ruan , Juanjuan Song , Yongxian Fan , Dongcheng Liu , Yanping Ren , Xiuqiong Zeng , Faqiong Zhao , Wenwei Zhang , Mei Shi , Min Hu , Wan Li , Xiuyun Wang , Weihong Li , Xiaohang Qiu , Yong Fan , Jianrong Zhang , Shuyong Zhang . Solid-Liquid Separation and Suggestions on the Operation Standards (I): Decantation and Centrifugation with Centrifuge Operation. University Chemistry, 2026, 41(3): 122-129. doi: 10.12461/PKU.DXHX202507037
15. [15]
  Jiarong Feng , Yejie Duan , Chu Chu , Dezhen Xie , Qiu'e Cao , Peng Liu . Preparation and Application of a Streptomycin Molecularly Imprinted Electrochemical Sensor: A Suggested Comprehensive Analytical Chemical Experiment. University Chemistry, 2024, 39(8): 295-305. doi: 10.3866/PKU.DXHX202401016
16. [16]
  .
  CCS Chemistry 综述推荐│绿色氧化新思路：光/电催化助力有机物高效升级
  . CCS Chemistry, 2025, 7(10.31635/ccschem.024.202405369): -.
17. [17]
  Yifan Liu , Haonan Peng . AI-Assisted New Era in Chemistry: A Review of the Application and Development of Artificial Intelligence in Chemistry. University Chemistry, 2025, 40(7): 189-199. doi: 10.12461/PKU.DXHX202405182
18. [18]
  Qian Wu , Hongmei Lu . Practical task-driven flipped classroom teaching design for “advanced separation and analysis”. University Chemistry, 2026, 41(4): 165-172. doi: 10.12461/PKU.DXHX202504039
19. [19]
  Runjie Li , Hang Liu , Xisheng Wang , Wanqun Zhang , Wanqun Hu , Kaiping Yang , Qiang Zhou , Si Liu , Pingping Zhu , Wei Shao . 氨基酸的衍生及手性气相色谱分离创新实验. University Chemistry, 2025, 40(6): 286-295. doi: 10.12461/PKU.DXHX202407059
20. [20]
  Yiru Wang , Zhiqiang Dong , Juanjuan Song , Yongxian Fan , Dongcheng Liu , Yanping Ren , Xiuqiong Zeng , Faqiong Zhao , Wenwei Zhang , Mei Shi , Min Hu , Wan Li , Xiuyun Wang , Weihong Li , Xiaohang Qiu , Yong Fan , Jianrong Zhang , Shuyong Zhang . Solid-Liquid Separation and Suggestions on the Operation Standards (II): Gravity Filtration and Vacuum Filtration with Vacuum Pump Operation. University Chemistry, 2026, 41(3): 130-142. doi: 10.12461/PKU.DXHX202507042

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(593)
HTML views(64)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142