Citation:
WAN A-Jun, WANG Kun, ZHANG Hong-Cai, LI Hui-Li, WANG De-Nong. Modern Carbohydrate Microarray Bio-chip Technologies[J]. Chinese Journal of Analytical Chemistry,
;2012, 40(11): 1780-1788.
doi:
10.3724/SP.J.1096.2012.20448
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Carbohydrate microarray (glyco-chip), is one of modern biotechnologies for monitoring the molecular interactions between carbohydrate ligands and other biomacromolecules. It is characterized by micro-scale, quickness, high sensitivity and high-throughput and is widely applicable in many fields. Its promising R & D areas include, but are not limited to, biology, basic medical research, clinical diagnostics, drug development and bio-material & reagent industry. This article intends to summarize methods that are currently used for the construction of glyco-chips, such as immobilization of either chemically modified or non-modified carbohydrates and procedures of self-assembly for production of three-dimensional glyco-chips. Current challenges and future trends in the R & D of glyco-chips are also discussed.
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Keywords:
- Microarray,
- Bio-chips,
- Carbohydrate microarray,
- Self-assembly,
- Review
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