Citation: YE Hai-Ying, ZHENG Shui-Qing, LIANG Chen, WANG Rong, Zhang Yu-Rong, ZHANG Ling-Yi, Zhang Wei-Bing, ZHANG Run-Sheng. Analysis of Seven Drugs in Human Hair by Hybrid Linear Ion Trap/Orbitrap Mass Spectrometry[J]. Chinese Journal of Analytical Chemistry, ;2012, 40(11): 1674-1679. doi: 10.3724/SP.J.1096.2012.20244 shu

Analysis of Seven Drugs in Human Hair by Hybrid Linear Ion Trap/Orbitrap Mass Spectrometry

1.
¹ Shanghai Institiute of Forensic Science, Shanghai Key Laboratory of Crime Scene Evidence-State Key Laboratory Breeding Base of Crime Scene Evidence, Shanghai, 200083 China;

Corresponding author: ZHANG Run-Sheng,
Received Date: 12 March 2012
Available Online: 20 July 2012
Fund Project: 本文系公安部应用创新计划(No. 2009YYCXSHSJ033)资助项目 (No. 2009YYCXSHSJ033)

A new method was developed for the determination of seven illicit drugs and metabolites in human hair by ultra high performance liquid chromatograph tandem a linear ion trap-orbitrap hybrid instrument at high mass resolution (UHPLC-LTQ-Orbitrap/MS). After being washed and grinded, the hair samples were soaked in pH 9.2 borate buffer with ultrasonic for 90 min. Then the samples were extracted by solid phase extraction (SPE). High resolution mass spectrometry was applied to reduce matrix interference. Full scanning of electrostatic field orbitrap was applied for quantification of drugs. The limits of detection (LOD) of seven illicit drugs and metabolites in human hair were 0.001-0.02 μg/g. The method showed a fairly good linearity over the range of 0.05-50 μg/g (r>0.9975). The spiked recoveries were between 76.1%-109.6%, and the deviation of intra-and inter-day precision was less than 14.9%. The method is simple, high sensitive, and suitable for the determination of illicit drugs in human hair.
- Linear ion trap/orbitrap mass spectrometry,
- Opiates,
- Ketamine,
- Methadone,
- Solid phase extraction,
- Ultra high performance liquid chromatography,
- Hair
1. [1]
  1 SHEN Min, XIANG Ping. Fundamentals and Applications of Hair Analysis. Beijing: Science Press, 2010: 13-92
2. [2]
  沈敏, 向平. 毛发分析基础及应用. 北京:科学出版社, 2010: 13-92
3. [3]
  2 XIANG Ping, SHEN Min, SHEN Bao-Hua, BO Jun, LIU Xiao-Qian, JIANG Yan, ZHUO Xian-Yi. J. Forensic Med., 2005, (4): 290-293
4. [4]
  向平, 沈敏, 沈保华, 卜俊, 刘晓茜, 姜宴, 卓先义. 法医学杂志, 2005, (4): 290-293
5. [5]
  3 Janicka M, Kot-Wasik A, Namiesnik J. Trends Analytical Chem., 2010, 29(3): 209-224
6. [6]
  4 Joakim J S, Fredrik C K, Kanar A, Anna G, Kolbjrn Z, Olav S, Henrik D. Toxicol. Letters, 2006,166: 11-18
7. [7]
  5 SUN Qi-Ran, XIANG Ping, YAN Hui, SHEN Min. Acta Pharm. Sin., 2008, 43(12): 1217-1223
8. [8]
  孙其然, 向平, 严慧, 沈敏. 药学学报, 2008, 43(12): 1217-1223
9. [9]
  6 Musshoff F, Lachenmeier K, Wollersen H, Lichtermann D, Madea B. J. Anal. Toxicol, 2005, (29): 345-352
10. [10]
  7 ZHANG Run-Sheng, WANG Kua-Dou, GONG Fei-Jun, YE Hai-Ying, ZHANG Yu-Rong, YAN Song-Mao, DU Yi-Ping, ZHANG Wei-Bing. Chinese J. Anal. Chem., 2012, 40(6): 915-919
11. [11]
  张润生, 王跨陡, 龚飞君, 叶海英, 张玉荣, 严松茂, 杜一平, 张维冰. 分析化学, 2012, 40(6): 915-919
12. [12]
  8 SHEN Min, SHEN Bao-Hua. J. Chin. Mass Spec. Society, 2002, (1): 11-16
13. [13]
  沈敏, 沈保华. 质谱学报, 2002, (1): 11-16
14. [14]
  9 GUO Fei, WANG Yan-Yan, MENG Pin-Jia, ZHANG Liang, YANG Yong, WANG Ji-Fen. Chinese J. Anal. Chem., 2009, 37(9): 1263-1268
15. [15]
  国菲, 王燕燕, 孟品佳, 张亮, 杨勇, 王继芬. 分析化学, 2009, 37(9): 1263-1268
16. [16]
  10 Klys M, Rojek S, Kulikowska J, Bozek E, Scislowski M. J. Chromatogr. B, 2007, 854(1-2): 299-307
17. [17]
  11 Scheidweiler K B, Huestis M A. Anal. Chem., 2004, 76(6): 4358-4363
18. [18]
  12 MENG Liang, WANG Yan-Yan, MENG Pin-Jia, WANG Yan-Ji, ZHANG Qiang. Chinese J. Anal. Chem., 2011, 39(7): 1077-1082
19. [19]
  孟梁, 王燕燕, 孟品佳, 王彦吉, 张强. 分析化学, 2011, 39(7): 1077-1082
20. [20]
  13 LIU Yan-Ming,TIAN Wei. Chem. J. Chinese Universities,2009, 30(1):51-53
21. [21]
  刘彦明, 田伟. 高等学校化学学报, 2009, 30(1):51-53
22. [22]
  14 MENG Liang, ZANG Xiang-Ri, SHEN Gui-Juan, WANG Zheng-Qiao, WANG Li-Li, ZHU Ling. Chinese J. Anal. Chem., 2010, 38(10): 1474-1478
23. [23]
  孟梁, 臧祥日, 申贵隽, 王正巧, 王莉莉, 祝玲. 分析化学, 2010, 38(10): 1474-1478
24. [24]
  15 ZHANG Jian-Xin, MENG Pin-Jia, ZHANG Da-Ming, ZHANG Wen-Fang, CHEN Cun-Yi. J. Hygiene Research., 2010, 39(5): 593-596
25. [25]
  张建新, 孟品佳, 张大明, 张文芳, 陈存仪. 卫生研究, 2010, 39(5): 593-596
26. [26]
  16 WANG Yong-Wei, LI Xiu-Qin, TIAN Jin-Guo. Environmental Chem., 2010, 29(1): 156-157
27. [27]
  王勇为, 李秀琴, 田进国. 环境化学, 2010, 29(1): 156-157
28. [28]
  17 WANG Xiao-Bing, DING Li, ZHU Shao-Hua, DAI Hua, XU Zhou, JIAO Yan-Na, WANG Li-Yue. Packaging Engineering., 2011,(15): 43-47
29. [29]
  王晓兵, 丁利, 朱绍华, 戴华, 许宙, 焦艳娜, 王利岳. 包装工程, 2011, (15): 43-47
1. [1]
  Yanhui Zhong , Ran Wang , Zian Lin . Analysis of Halogenated Quinone Compounds in Environmental Water by Dispersive Solid-Phase Extraction with Liquid Chromatography-Triple Quadrupole Mass Spectrometry. University Chemistry, 2024, 39(11): 296-303. doi: 10.12461/PKU.DXHX202402017
2. [2]
  Zunxiang Zeng , Yuling Hu , Yufei Hu , Hua Xiao . Analysis of Plant Essential Oils by Supercritical CO₂Extraction with Gas Chromatography-Mass Spectrometry: An Instrumental Analysis Comprehensive Experiment Teaching Reform. University Chemistry, 2024, 39(3): 274-282. doi: 10.3866/PKU.DXHX202309069
3. [3]
  Yifan Xie , Liyun Yao , Ruolin Yang , Yuxing Cai , Yujie Jin , Ning Li . Exploration and Practice of Online and Offline Hybrid Teaching Mode in High-Performance Liquid Chromatography Experiment. University Chemistry, 2025, 40(11): 100-107. doi: 10.12461/PKU.DXHX202412133
4. [4]
  Mingyang Men , Jinghua Wu , Gaozhan Liu , Jing Zhang , Nini Zhang , Xiayin Yao . Sulfide Solid Electrolyte Synthesized by Liquid Phase Approach and Application in All-Solid-State Lithium Batteries. Acta Physico-Chimica Sinica, 2025, 41(1): 100004-0. doi: 10.3866/PKU.WHXB202309019
5. [5]
  Chongjing Liu , Yujian Xia , Pengjun Zhang , Shiqiang Wei , Dengfeng Cao , Beibei Sheng , Yongheng Chu , Shuangming Chen , Li Song , Xiaosong Liu . Understanding Solid-Gas and Solid-Liquid Interfaces through Near Ambient Pressure X-Ray Photoelectron Spectroscopy. Acta Physico-Chimica Sinica, 2025, 41(2): 100013-0. doi: 10.3866/PKU.WHXB202309036
6. [6]
  Runjie Li , Hang Liu , Xisheng Wang , Wanqun Zhang , Wanqun Hu , Kaiping Yang , Qiang Zhou , Si Liu , Pingping Zhu , Wei Shao . 氨基酸的衍生及手性气相色谱分离创新实验. University Chemistry, 2025, 40(6): 286-295. doi: 10.12461/PKU.DXHX202407059
7. [7]
  Shunü Peng , Huamin Li , Zhaobin Chen , Yiru Wang . Simultaneous Application of Multiple Quantitative Analysis Methods in Gas Chromatography for the Determination of Active Ingredients in Traditional Chinese Medicine Preparations. University Chemistry, 2025, 40(10): 243-249. doi: 10.12461/PKU.DXHX202412043
8. [8]
  Ke Qiu , Fengmei Wang , Mochou Liao , Kerun Zhu , Jiawei Chen , Wei Zhang , Yongyao Xia , Xiaoli Dong , Fei Wang . A Fumed SiO₂-based Composite Hydrogel Polymer Electrolyte for Near-Neutral Zinc-Air Batteries. Acta Physico-Chimica Sinica, 2024, 40(3): 2304036-0. doi: 10.3866/PKU.WHXB202304036
9. [9]
  Gaoyan Chen , Chaoyue Wang , Juanjuan Gao , Junke Wang , Yingxiao Zong , Kin Shing Chan . Heart to Heart: Exploring Cardiac CT. University Chemistry, 2024, 39(9): 146-150. doi: 10.12461/PKU.DXHX202402011
10. [10]
  Yajie Li , Bin Chen , Yiping Wang , Hui Xing , Wei Zhao , Geng Zhang , Siqi Shi . Inhibiting Dendrite Growth by Customizing Electrolyte or Separator to Achieve Anisotropic Lithium-Ion Transport: A Phase-Field Study. Acta Physico-Chimica Sinica, 2024, 40(3): 2305053-0. doi: 10.3866/PKU.WHXB202305053
11. [11]
  Xiaowu Zhang , Pai Liu , Qishen Huang , Shufeng Pang , Zhiming Gao , Yunhong Zhang . Acid-Base Dissociation Equilibrium in Multiphase System: Effect of Gas. University Chemistry, 2024, 39(4): 387-394. doi: 10.3866/PKU.DXHX202310021
12. [12]
  Chunai Dai , Yongsheng Han , Luting Yan , Zhen Li , Yingze Cao . Ideological and Political Design of Solid-liquid Contact Angle Measurement Experiment. University Chemistry, 2024, 39(2): 28-33. doi: 10.3866/PKU.DXHX202306065
13. [13]
  Jiao CHEN , Yi LI , Yi XIE , Dandan DIAO , Qiang XIAO . Vapor-phase transport of MFI nanosheets for the fabrication of ultrathin b-axis oriented zeolite membranes. Chinese Journal of Inorganic Chemistry, 2024, 40(3): 507-514. doi: 10.11862/CJIC.20230403
14. [14]
  Zhiwen HU , Weixia DONG , Qifu BAO , Ping LI . Low-temperature synthesis of tetragonal BaTiO₃ for piezocatalysis. Chinese Journal of Inorganic Chemistry, 2024, 40(5): 857-866. doi: 10.11862/CJIC.20230462
15. [15]
  Haiyang Zhang , Yanzhao Dong , Haojie Li , Ruili Guo , Zhicheng Zhang , Jiangjiexing Wu . Exploring the Integration of Chemical Engineering Principle Experiment with Cutting-Edge Research Achievements. University Chemistry, 2024, 39(10): 308-313. doi: 10.12461/PKU.DXHX202405035
16. [16]
  Xiaojun Liu , Lang Qin , Yanlei Yu . Dynamic Manipulation of Photonic Bandgaps in Cholesteric Liquid Crystal Microdroplets for Applications. Acta Physico-Chimica Sinica, 2024, 40(5): 2305018-0. doi: 10.3866/PKU.WHXB202305018
17. [17]
  Yuanchun Pan , Xinyun Lin , Leyi Yang , Wenya Hu , Dekui Song , Nan Liu . Artificial Intelligence Science Practice: Preparation of Electronic Skin by Chemical Vapor Deposition of Graphene. University Chemistry, 2025, 40(11): 272-280. doi: 10.12461/PKU.DXHX202412052
18. [18]
  Jiandong Liu , Zhijia Zhang , Kamenskii Mikhail , Volkov Filipp , Eliseeva Svetlana , Jianmin Ma . Research Progress on Cathode Electrolyte Interphase in High-Voltage Lithium Batteries. Acta Physico-Chimica Sinica, 2025, 41(2): 100011-0. doi: 10.3866/PKU.WHXB202308048
19. [19]
  Binbin Liu , Yang Chen , Tianci Jia , Chen Chen , Zhanghao Wu , Yuhui Liu , Yuhang Zhai , Tianshu Ma , Changlei Wang . Hydroxyl-functionalized molecular engineering mitigates 2D phase barriers for efficient wide-bandgap and all-perovskite tandem solar cells. Acta Physico-Chimica Sinica, 2026, 42(1): 100128-0. doi: 10.1016/j.actphy.2025.100128
20. [20]
  Shan Zhao , Xu Liu , Haotian Guo , Zonglin Liu , Pengfei Wang , Jie Shu , Tingfeng Yi . Synergistic design of high-entropy P2/O3 biphasic cathodes for high-performance sodium-ion batteries. Acta Physico-Chimica Sinica, 2026, 42(1): 100129-0. doi: 10.1016/j.actphy.2025.100129

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(619)
HTML views(57)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142