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Citation: YANG Qingcui, SUN Xiaohong, LIU Yuanfa, CHEN Bang, SHEN Shengqiang. Synthesis and Antifungal Activity of Schiff Bases of 5-Ethoxycarbonylmethylsulfanyl-1,2,4-triazole[J]. Chinese Journal of Applied Chemistry, ;2014, 31(7): 788-792. doi: 10.3724/SP.J.1095.2014.30488 shu

Synthesis and Antifungal Activity of Schiff Bases of 5-Ethoxycarbonylmethylsulfanyl-1,2,4-triazole

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a College of Chemical Engineering, Northwest University, Xi'an 710069, China;
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b School of Science, Xi'an University of Architecture and Technology, Xi'an 710055, China;
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c Chemical Research Institute, College of Chemical Engineering, Northwest University, Xi'an 710069, China;
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d College of Chemistry and Materials Science, Northwest University, Xi'an 710069, China

Corresponding author: SUN Xiaohong,
Received Date: 26 September 2013
Available Online: 2 January 2014
Fund Project: 国家自然科学基金资助项目(21073141) (21073141)陕西省教育厅自然科学专项基金资助项目(2013JK0666) (2013JK0666)

Nine Shiff bases 3-methyl-4-(X-substituted-benzylideneamino)-5-ethoxycarbonyl methylsulfanyl-1,2,4-triazole a~i were synthesized from 3-methyl-4-amino-5-ethoxycarbonylmethyl sulfanyl-1,2,4-triazole and substituted aromatic aldehydes.The structures of synthetic compounds were confirmed by ¹H NMR,IR,MS analyses.The crystal structure of 3-methyl-4-(4-hydroxybenzylideneamino)-5-ethoxycarbonylmethylsulfanyl-1,2,4-triazole h(CCDC:910927) was determined by X-ray diffraction as:C₁₄H₁₆N₄O₃S,M_r=320.37,Orthorhombic,P2(1)2(1)2(1)/n,a=0.9220(10) nm,b=1.5823(17) nm,c=2.1667(2) nm,V=3.161(6) nm³,Z=8,F(000)=1344.The antifungal activities of the new Schiff bases against four vegetable pathogens have been tested.The EC₉₅ values of compounds d,e and f against Gibberlla saubinetii and Fusarium oxysporium f.s.px.niveum indicate that their antifungal activities are better than that of triadimefon.
- Schiff base,
- methyl-amino-ethoxycarbonylmethylsulfanyl-triazole,
- synthesis,
- antifungal activity
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