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Citation: ZHANG Jing, ZHAO Wenyan, LIU Fuqiang, WANG Xiaoli. Determination of Gatifloxacin or Fleroxacin in Water Sample by Ultrasound-Assisted Ionic Liquid Liquid-Phase Microextraction Coupled with High Performance Liquid Chromatography[J]. Chinese Journal of Applied Chemistry, ;2014, 31(6): 737-741. doi: 10.3724/SP.J.1095.2014.30387 shu

Determination of Gatifloxacin or Fleroxacin in Water Sample by Ultrasound-Assisted Ionic Liquid Liquid-Phase Microextraction Coupled with High Performance Liquid Chromatography

1.
College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, China

Corresponding author: ZHAO Wenyan,
Received Date: 30 July 2013
Available Online: 15 October 2013
Fund Project: 国家自然科学基金资助项目(21167008) (21167008)内蒙古自治区教育厅重点项目(NJZZ11014) (NJZZ11014)

A method was established for the analysis of gatifloxacin or fleroxacin in water sample by ultrasonic assisted hydrophobic ionic liquid(1-hexyl-3-methylimidazolium hexafluorophosphate,[C₆mim][PF₆]) liquid-phase microextraction coupled with high performance liquid chromatography(HPLC).The pH value of solution,amount of ionic liquid and other factors which might affect the extraction efficiency were researched.To gatifloxacin water sample at pH=3.3 and fleroxacin water sample at pH=2.1 was added 0.4 mL of[C₆mim][PF₆],respectively,for ultrasonic extraction.After extraction,phase separation was performed by centrifugation.The sediment phase were injected into the HPLC system for analysis.By this method,the linear ranges for analysis are 0.5~100 μg/L and the relative standard deviations(n=5) for them are 2.80 and 5.93,respectively.The limits of detection(3S/N) for gatifloxacin and fleroxacin are 0.46 and 0.97 μg/L,respectively.Under the above mentioned conditions,the extraction recoveries for gatifloxacin or fleroxacin water samples were found to be 80.5%~89.5% and 93.3%~99.0%,respectively.
- gatifloxacin,
- fleroxacin,
- ionic liquid,
- ultrasounic extraction
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