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Citation: ZHANG Baohua, SHI Lanxiang. New Preparation Process for (R)-1-(4-Benzyloxy-3-nitrophenyl)-2-Bromoethanol[J]. Chinese Journal of Applied Chemistry, ;2013, 30(11): 1369-1371. doi: 10.3724/SP.J.1095.2013.30005 shu

New Preparation Process for (R)-1-(4-Benzyloxy-3-nitrophenyl)-2-Bromoethanol

College of Chemical Engineering, Shijiazhuang University, Shijiazhuang 050035, China

Received Date: 4 January 2013
Revised Date: 21 March 2013

(R)-1-(4-Benzyloxy-3-nitrophenyl)-2-bromoethanol,a key intermediate for the preparation of (R,R)-formoterol,was prepared from 4-benzyloxy-3-nitrophenyl-α-bromoacetophenone using BH₃ complex with polymer-bonded (R)-diphenylpyrrolidinemethanol as the catalyst and NaBH₄/Me₃SiCl as reductant via an enantioselective reduction. The yield and ee value for the reaction are 95% and 95.4% respectively. The resulted chiral compounds can be easily separated and recycled,which reduce the production cost. Using NaBH₄/Me₃SiCl as the reductant could minimize the toxicity of the reaction and help to improve the safety issue.
- (R)-(benzyloxy-nitrophenyl)-bromoethanol,
- NaBH₄/Me₃SiCl,
- enantioselective reduction,
- bonded(R)-diphenylpyrrolidinemethanol
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