引用本文:
戴燕, 吕春旭, 李斌栋, 谭卫红. 微波辅助氢氧化钾催化合成2-(4-羟基苯基)六氟异丙醇[J]. 应用化学,
2013, 30(12): 1438-1442.
doi:
10.3724/SP.J.1095.2013.20590
Citation: DAI Yan, LV Chunxu, LI Bindong, TAN Weihong. Microwave-Assisted Synthesis of 2-(4-Hydroxy-phenyl)-1,1,1,3,3,3-hexafluoro-propan-2-ol via Potassium Hydroxide as the Catalyst[J]. Chinese Journal of Applied Chemistry, 2013, 30(12): 1438-1442. doi: 10.3724/SP.J.1095.2013.20590
Citation: DAI Yan, LV Chunxu, LI Bindong, TAN Weihong. Microwave-Assisted Synthesis of 2-(4-Hydroxy-phenyl)-1,1,1,3,3,3-hexafluoro-propan-2-ol via Potassium Hydroxide as the Catalyst[J]. Chinese Journal of Applied Chemistry, 2013, 30(12): 1438-1442. doi: 10.3724/SP.J.1095.2013.20590
微波辅助氢氧化钾催化合成2-(4-羟基苯基)六氟异丙醇
English
Microwave-Assisted Synthesis of 2-(4-Hydroxy-phenyl)-1,1,1,3,3,3-hexafluoro-propan-2-ol via Potassium Hydroxide as the Catalyst
Abstract:
With the assistance of microwave,a mixture of 2-(4-hydroxy-phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol isomers were obtained via the condensation between hexafluoroacetone trihydrate (HFA·3H2O) and phenol using potassium hydroxide as catalyst. The product was characterized by 1H NMR,IR and MS spectra. The results show that the microwave-assisted process can reduce the reaction time remarkably compared with conventional processes. Under optimal conditions with the microwave power 300 W at n(phenol):n (HFA·3H2O):n (KOH)=3.0:1.0:0.3,the reaction time are shortened from 35 h in conventional heating to 6 h,the total yield is increased from 87% to 90% with 94% selectivity.
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