引用本文:
徐锁平, 卢晗, 徐进红. 5-氯水杨醛缩乙醇胺合铜(Ⅱ)的微波直接合成、晶体结构及抑菌活性[J]. 应用化学,
2013, 30(3): 295-299.
doi:
10.3724/SP.J.1095.2013.20150
Citation: XU Suoping, LU Han, XU Jinhong. Microwave Synthesis,Crystal Structure and Antibacterial Activities of 5-Chlorosalicylaldehyde-2aminoethanol-copper(Ⅱ)[J]. Chinese Journal of Applied Chemistry, 2013, 30(3): 295-299. doi: 10.3724/SP.J.1095.2013.20150
Citation: XU Suoping, LU Han, XU Jinhong. Microwave Synthesis,Crystal Structure and Antibacterial Activities of 5-Chlorosalicylaldehyde-2aminoethanol-copper(Ⅱ)[J]. Chinese Journal of Applied Chemistry, 2013, 30(3): 295-299. doi: 10.3724/SP.J.1095.2013.20150
5-氯水杨醛缩乙醇胺合铜(Ⅱ)的微波直接合成、晶体结构及抑菌活性
摘要:
以5-氯水杨醛、乙醇胺和氯化铜为原料,在微波作用下合成了5-氯水杨醛缩乙醇胺合铜(Ⅱ)配合物。利用红外光谱、元素分析和单晶X射线衍射方法对目标化合物进行了表征,标题配合物为单斜晶系,P21/n空间群。晶胞参数:a=0.49793(6)nm,b=1.7037(6)nm,c=1.07120(12)nm,β=94.579(3)°,F(000)=470,Z=2,V=0.905(8)nm3,Dc=1.689 mg/m3,R[I>2σ(I)],R1=0.0624,ωR2=0.1555。配合物分子中,2种Schiff碱配体中的2个O原子和2个N原子参与配位,Cu(Ⅱ)处于四边形配位中心。用MTT法测得标题配合物对6种革兰氏细菌(B.subtilis、S.aureus、S.faecalis、P.aeruginosa、E.coli和E.cloacae)的最小抑制浓度分别为12.25、25、12.5、12.5、6.25和6.25 mg/L。
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关键词:
- 氯水杨醛缩乙醇胺合铜(Ⅱ)
- / 微波合成
- / 晶体结构
- / 抑菌活性
English
Microwave Synthesis,Crystal Structure and Antibacterial Activities of 5-Chlorosalicylaldehyde-2aminoethanol-copper(Ⅱ)
Abstract:
5-Chlorosalicylaldehyde-2-aminoethanol-copper(Ⅱ) was synthesized using 5-chlorosalicylaldehyde,2-aminoethanol and cupric chloride as precursors under microwave irradiation. The product was characterized by IR spectra,elemental analysis and single X-ray crystallography study. The title complex crystallizes in the monoclinic space group P21/n. Cell parameters:a=0.49793(6) nm,b=1.7037(2) nm,c=1.07120(12) nm,β=94.579(3)°,F(000)=470,Z=2,V=0.905(8) nm3,Dc=1.689 mg/m3,R[I>2σ(I)],R1=0.0624,ωR2=0.1555. The Cu(Ⅱ) adopts a square planar configuration coordinated by two nitrogen atoms and two oxygen atoms from two Schiff bases. The antibacterial (B.subtilis, S.aureus, S.faecalis, P.aeruginosa, E.coli and E.cloacae) activities of the compounds were assayed by MTT (3-(4,5-dimethylthiazol-2-yl) -2,5-diphenyl tetrazolium bromide) method. It showed favorable antimicrobial activity with minimal inhibitory concentrations(MICs) of 12.25,25,12.5,12.5,6.25 and 6.25 mg/L against B.subtilis, S.aureus, S.faecalis, P.aeruginosa, E.coli and E.cloacae, respectively.
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