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Citation: WANG Rulin, WANG Encheng, QIN Shuzhu, WANG Peng. Inclusion Properties of Piroxicam by β-Cyclodextrin and Its Derivatives[J]. Chinese Journal of Applied Chemistry, ;2012, 29(8): 910-914. doi: 10.3724/SP.J.1095.2012.00392 shu

Inclusion Properties of Piroxicam by β-Cyclodextrin and Its Derivatives

1.
The Chemistry Department of Shanxi Medical University, Taiyuan 030001, China

Corresponding author: WANG Rulin,
Received Date: 6 September 2011
Available Online: 24 November 2011
Fund Project: 山西省科技厅自然科学基金(20051029) (20051029)

The inclusion properties of piroxicam(PX) by β-cyclodextrin(β-CD),hydroxypropyl-β-cyclodextrin(HP-β-CD),and sulfobutyl ether-β-cyclodextrin(SBE-β-CD) were studied by fluorescence spectroscopy,differential scanning calorimetry(DSC) and NMR at different pH.The results showed that the 1: 2.5 inclusion compounds were formed between piroxicam and CDs.Based on the formation constants,which were 2.0×10⁶,1.8×10⁶,1.2×10⁶ in neutral media,the inclusion capacity showed the order of SBE-β-CD >HP-β-CD >β-CD.
- piroxicam,
- β-cyclodextrin,
- fluorescence spectroscopy,
- DSC,
- NMR
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