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Citation: YANG Jie, LI Lizhong, SHEN Fengshan, LI Xiangdan. Ultrasound-assisted Synthesis of 3, 4-Dimethoxy-4'-hydroxychalcone[J]. Chinese Journal of Applied Chemistry, ;2012, 29(6): 724-726. doi: 10.3724/SP.J.1095.2012.00385 shu

Ultrasound-assisted Synthesis of 3, 4-Dimethoxy-4'-hydroxychalcone

1.
a College of Chemistry and Materials Science, South-Central University for Nationalities, Wuhan 430074, China;
2.
b College of Science, Yanbian University, Yanji 133400, China

Corresponding author: LI Xiangdan,
Received Date: 1 September 2011
Available Online: 1 December 2011
Fund Project: 湖北省自然科学基金资助项目(2008CDB25) (2008CDB25)

3,4-Dimethoxy-4'-hydroxychalcone was synthesized by the Claisen-Schmidt condensation using 3,4-dimethoxybenzaldehyde and 4'-hydroxyacetophenone as reagents with ultrasonic radiation and dry HCl(g) as catalyst.The structure of the product was confirmed by IR and ¹H NMR.The optimized synthesis conditions were to use anhydrous ethanol as the solvent,reaction temperature of 30℃,ultrasonic radiation of 240 W,and radiation time of 20 min.A yield of 92.1% was obtained for the reaction with 1: 1 stoichiometric ratio for the starting materials.Compared with previous method in the literature,the present procedure requires a shorter reaction time,and has easier work-up and higher yield.
- dimethoxyhydroxy chalcone,
- ultrasound,
- synthesis
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