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Citation: ZHENG Yuguo, GUO Qingqing, XIONG Zhuang, HE Yong, YANG Tao, LU Ping, WEI Xue, XUE Wei. Synthesis and Biological Activity of Anthranilic Diamides Compounds Containing Methoxy and Benzothiazole[J]. Chinese Journal of Applied Chemistry, ;2012, 29(7): 762-768. doi: 10.3724/SP.J.1095.2012.00339 shu

Synthesis and Biological Activity of Anthranilic Diamides Compounds Containing Methoxy and Benzothiazole

ZHENG Yuguo ^a,b ,
GUO Qingqing ^a,b ,
XIONG Zhuang ^a ,
HE Yong ^a ,
YANG Tao ^a ,
LU Ping ^a ,
WEI Xue ^a ,
XUE Wei ^a,,

1.
a Key Laboratory of Green Pesticide and Bioengineering, Ministry of Education, Research and Development Center for Fine Chemicals, Guizhou University, Guiyang 550025, China;
2.
b Department of Chemistry and Biological, Xingyi Normal University of Nationalities, Xingyi 562400, China

Corresponding author: XUE Wei,
Received Date: 29 July 2011
Available Online: 4 October 2011
Fund Project: 国家自然科学基金(21062005) (21062005)贵州省教育厅自然科学研究项目(黔教科2010090)资助项目 (黔教科2010090)

Thirteen novel bisamides compounds containing methoxy and benzothiazole were synthesized.Their structures were characterized by ¹H NMR,¹³C NMR,IR and elemental analyses.Preliminary bioassay showed that some of them exhibited certain anti-CMV activities,and some compounds posed antitumor activity toward PC3 cells in vitro by MTT method.The antiproliferation activity of compound 4f to PC3 cells was 74.2% at the concentration of 10 μmol/L.
- bisamides,
- benzothiazole,
- methoxy,
- bioactivity
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