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Citation: WANG Qin, ZHANG Yanjun, DU Xi, PENG Ruiguang. Asymmetric Addition of Phenylacetylene and Benzaldehyde Catalyzed by Chiral 1,1'-Bi-2-naphthol Derivatives[J]. Chinese Journal of Applied Chemistry, ;2011, 28(1): 121-122. doi: 10.3724/SP.J.1095.2011.00234 shu

Asymmetric Addition of Phenylacetylene and Benzaldehyde Catalyzed by Chiral 1,1'-Bi-2-naphthol Derivatives

WANG Qin ^a,, ,
ZHANG Yanjun ^b ,
DU Xi ^b ,
PENG Ruiguang ^a

1.
a Department of Pharmacy, Luzhou Medical College, Luzhou 646000;
2.
b Staff Room of Chemistry, Luzhou Medical College, Luzhou 646000

Corresponding author: WANG Qin,
Received Date: 21 April 2010
Available Online: 14 June 2010
Fund Project: 四川省教育厅项目(07ZZ014) (07ZZ014)四川省青年科技基金(2009-26-417) (2009-26-417)四川省科技厅项目(2008JY0090,2008SZ0052) (2008JY0090,2008SZ0052)

Chiral 3,3'-substituted 1,1'-bi-2-napthol(BINOL) derivatives were synthesized from BINOL. The asymmetric addition of phenylacetylene and benzaldehyde in the presence of the BINOL derivative and diethyl zinc afforded the corresponding propargylic alcohols with 73% yield and 40% enatiomeric excess.
- substitued bi-naphthol,
- asymmetric addition,
- propargylic alcohol
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