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Citation: SU Gui-Fa, ZHOU Yi-Ming, QIN Jiang-Ke, DENG Ye-Cheng, ZHANG Ming, WANG Zhong-Chang, ZONG Xi. Synthesis,Characterization and Antibacterial Activity of 3-Substituted-6-(4'-decarboxydehydroabietyl)-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole Derivatives[J]. Chinese Journal of Applied Chemistry, ;2010, 27(6): 651-657. doi: 10.3724/SP.J.1095.2010.90513 shu

Synthesis,Characterization and Antibacterial Activity of 3-Substituted-6-(4'-decarboxydehydroabietyl)-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole Derivatives

a. Key Laboratory for the Chemistry and Molecular Engineering of Medicial Resources of State Education Ministry, College of Chemistry & Chemical Engineering, Guangxi Normal University, Guilin 541004;
b. College of Life Science, Guangxi Normal University, Guilin 541004

Received Date: 30 July 2009
Revised Date: 5 January 2010

Fourteen new 3-substituted-6-(4'-decarboxydehydroabietyl)-1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazoles 5a~5e and 11a~11i were obtained from the reaction of 3-substituted-4-amino-5-mercapto-1,2,4-triazoles 4 and 10 with dehydroabietic acid 1 in the presence of phosphorus oxychloride,respectively.All target compounds were characterized by IR,¹H NMR,¹³C NMR and MS.The preliminary antibacterial activity assay showed that title compounds 5 and 11 exhibited a fungicidal activity against C.Albicans, E.coli., M.Luteus and S.Dysenteriae.
- dehydroabietic acid,
- triazolo[3,4-b]thiadiazole,
- antibacterial activity
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