咪唑盐类聚离子液体抗菌剂的制备及其在水凝胶敷料中的应用

周超 生程钜 闻林林

引用本文: 周超, 生程钜, 闻林林. 咪唑盐类聚离子液体抗菌剂的制备及其在水凝胶敷料中的应用[J]. 应用化学, 2021, 38(1): 51-59. doi: 10.19894/j.issn.1000-0518.200214 shu
Citation:  ZHOU Chao,  SHENG Cheng-Ju,  WEN Lin-Lin. Preparation of Imidazolium Salt-based Poly(ionic liquids) Antibacterial Agent and Its Application in Hydrogel Dressing[J]. Chinese Journal of Applied Chemistry, 2021, 38(1): 51-59. doi: 10.19894/j.issn.1000-0518.200214 shu

咪唑盐类聚离子液体抗菌剂的制备及其在水凝胶敷料中的应用

    通讯作者: 周超,E-mail:zhouchao@cczu.edu.cn
  • 基金项目:

    江苏省高等学校自然科学研究面上项目(No.19KJD430001)和江苏省自然科学基金(青年基金)项目(No.BK20180963)资助

摘要: 皮肤伤口的感染严重威胁患者的生命安全,虽然传统的含有银离子或小分子抗生素的抗菌水凝胶伤口敷料具有广谱的杀菌功效,但这些抗菌水凝胶敷料中的抗菌剂存在一定的生物毒性和耐药性风险,无法满足临床长期使用的要求。咪唑盐类聚离子液体由于其含有较强的正电荷效应以及疏水链段,因此其作为新型的聚合物抗菌剂具有较强的抗菌效果。本研究首先通过采用Radziszewski缩聚反应,制备了具有较强抗菌性能的含呋喃官能团的咪唑盐类聚离子液体;其次,将含呋喃官能团的咪唑盐类聚离子液体采用Diels-Alder“点击”反应与透明质酸/聚乙二醇复合,以制备含有咪唑盐类聚离子液体抗菌水凝胶。通过体外实验表明:含咪唑盐类聚离子液体抗菌水凝胶在快速杀灭细菌的同时,对人皮肤的成纤维细胞具有较低的毒性。有望应用在皮肤创面的抗感染及修复领域。

English


    1. [1] TUNG N, HUYEN V, CHI S J A, et al. Topical delivery of dexamethasone acetate from hydrogel containing nanostructured liquid carriers and the drug[J]. Arch Pharmacal Res, 2015, 38(11):1999-2007.

    2. [2] HE M, WANG Q, SHI Z, et al. Inflammation-responsive self-regulated drug release from ultrathin hydrogel coating[J]. Colloids Surf B, 2017, 158:518-526.

    3. [3] HOFFMAN A S. Hydrogels for biomedical applications[J]. Adv Drug Delivery Rev, 2002, 54(1):3-12.

    4. [4] ZHAO X, LI P, GUO B, et al. Antibacterial and conductive injectable hydrogels based on quaternized chitosan-graft-polyaniline/oxidized dextran for tissue engineering[J]. Acta Biomater, 2015, 26:236-248.

    5. [5] HUANG W, WANG Y, HUANG Z, et al. On-demand dissolvable self-healing hydrogel based on carboxymethyl chitosan and cellulose nanocrystal for deep partial thickness burn wound healing[J]. ACS Appl Mater Interfaces, 2018, 10(48):41076-41088.

    6. [6] XU Q, ZHENG Z, WANG B, et al. Zinc ion coordinated poly(ionic liquid) antimicrobial membranes for wound healing[J]. ACS Appl Mater Interfaces, 2017, 9(17):14656-14664.

    7. [7] QIN J, GUO J, XU Q, et al. Synthesis of pyrrolidinium-type poly(ionic liquid) membranes for antibacterial applications[J]. ACS Appl Mater Interfaces, 2017, 9(12):11299-11306.

    8. [8] QIAN W, TEXTER J, YAN F. Frontiers in poly(ionic liquid)s:syntheses and applications[J]. Chem Soc Rev, 2017, 46(4):1124-1159.

    9. [9] SAXER S, MARESTIN C, MERCIER R, et al. The multicomponent Debus-Radziszewski reaction in macromolecular chemistry[J]. Polym Chem, 2018, 9(15):1927-1933.

    10. [10] YU F, CAO X, LI Y, et al. Diels-Alder crosslinked HA/PEG hydrogels with high elasticity and fatigue resistance for cell encapsulation and articular cartilage tissue repair[J]. Polym Chem, 2014, 5(17):5116-5123.

    11. [11] CRUZACUNA R, QUIROS M, HUANG S, et al. PEG-4MAL hydrogels for human organoid generation, culture, and in vivo delivery[J]. Nat Protoc, 2018, 13(9):2102-2119.

    12. [12] BADAWY M E I, LOTFY T M R, SHAWIR S M S. Facile synthesis and characterizations of antibacterial and antioxidant of chitosan monoterpene nanoparticles and their applications in preserving minced meat[J]. Int J Biol Macromol, 2020, 156:127-136.

    13. [13] COSTERTON J W, STEWART P S, GREENBERG E P. Bacterial biofilms:a common cause of persistent infections[J]. Science, 1999, 284(5418):1318-1322.

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  • 收稿日期:  2020-07-17
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