Citation: YU Jing, YAO Zhi-Hao, HE Kai-Yu, XING Bing-Cong, WANG Qiang, CHENG Ke-Jun, WANG Liu, XU Xia-Hong. Nanomaterials-based Optical Biosensors for Detection of Mycotoxins in Traditional Chinese Medicine[J]. Chinese Journal of Analytical Chemistry, ;2023, 51(4): 472-483. doi: 10.19756/j.issn.0253-3820.221510 shu

Nanomaterials-based Optical Biosensors for Detection of Mycotoxins in Traditional Chinese Medicine

YU Jing ^1,2 ,
YAO Zhi-Hao ² ,
HE Kai-Yu ² ,
XING Bing-Cong ¹ ,
WANG Qiang ² ,
CHENG Ke-Jun ^1,3,, ,
WANG Liu ^2,4,, ,
XU Xia-Hong ^2,,

1.
Zhejiang Provincial Key Laboratory of Resources Protection and Innovation of Traditional Chinese Medicine, Zhejiang A&F University, Hangzhou 311300, China;
2.
Institute of Agro-product Safety and Nutrition, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China;
3.
Lishui Institute of Agriculture and Forestry Sciences, Lishui 323000, China;
4.
Key Laboratory of Traceability for Agricultural Genetically Modified Organisms, Ministry of Agriculture and Rural Affairs, Hangzhou 310021, China

Corresponding author: CHENG Ke-Jun, WANG Liu, XU Xia-Hong,
Received Date: 13 October 2022
Revised Date: 7 February 2023

Fund Project: Supported by the Key Research and Development Program of Zhejiang Province, China (No. 2021C02062), the National Natural Science Foundation of China (Nos. 32172307, 32072303) and the Scientific Research Project of Department of Education of Zhejiang Province, China (No. Y202044948).

With the rapid development of traditional Chinese medicine (TCM) industry, the demand of TCM is increasing. The quality and safety of TCM are attracting more and more attention. Mycotoxin pollution, which not only affects the quality, and in serious cases, also may cause carcinogenic, teratogenic and mutagenic effects on human body, has become one of the key safety issues of TCM. Rapid and accurate detection of mycotoxins in TCM is essential to ensure the quality and safety. Optical biosensors have been widely applied to rapid detection of mycotoxins due to their advantages such as simplicity to operate, fast response, high sensitivity, and good accuracy. Notably, nanomaterials are extensively used in optical biosensors owing to their unique physicochemical and catalytic properties. This review summarized the optical biosensors for mycotoxins in recent years. The principles, application characteristics and construction methods progress of optical biosensors were emphasized. The optical biosensors were classified into fluorescence, colorimetry, chemiluminescence, surface enhanced Raman scattering and polarized light for detailed discussion. The effects of the main matrix components of TCM on optical biosensors were comprehensively discussed. The challenges and perspectives of optical biosensors for detection of mycotoxins in TCM were highlighted. It was aimed to provide guidance for sensitive, accurate and convenient supervision of the quality of Chinese medicinal materials.
- Nanomaterials,
- Traditional Chinese medicine,
- Mycotoxin,
- Optical biosensors,
- Review
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