主动靶向近红外二区诊疗一体化纳米颗粒用于三阴性乳腺癌的研究

邹志凤 高晶 来旖 徐志爱

引用本文: 邹志凤, 高晶, 来旖, 徐志爱. 主动靶向近红外二区诊疗一体化纳米颗粒用于三阴性乳腺癌的研究[J]. 分析化学, 2022, 50(6): 912-923. doi: 10.19756/j.issn.0253-3820.221115 shu
Citation:  ZOU Zhi-Feng,  GAO Jing,  LAI Yi,  XU Zhi-Ai. Tumor-Targeted Theranostic Probe for Near Infrared Ⅱ Window Fluorescence Imaging and Anticancer Therapy of Triple-Negative Breast Cancer[J]. Chinese Journal of Analytical Chemistry, 2022, 50(6): 912-923. doi: 10.19756/j.issn.0253-3820.221115 shu

主动靶向近红外二区诊疗一体化纳米颗粒用于三阴性乳腺癌的研究

    通讯作者: 徐志爱,E-mail:zaxu@chem.ecnu.edu.cn
  • 基金项目:

    国家自然科学基金项目(No.22074043)资助。

摘要: 供体-受体-供体(D-A-D)型荧光探针通常具有优异的光学稳定性和生物相容性。通过分子设计,D-A-D型分子的荧光发射可以到达近红外二区(NIR-Ⅱ),同时还具有光热转换性质,因此具有生物成像和光热治疗的潜力。但是,D-A-D型分子的分子量较大,水溶性差,严重限制了其在生物诊疗领域的应用。本研究设计了具有肿瘤主动靶向性的高分子聚合物(CRGDK-PEG-b-PLGA)用于负载D-A-D型荧光探针(TQTCD),从而提高了TQTCD探针的水溶性、肿瘤特异性和光热治疗效果,并实现了诊疗一体化。CRGDK-PEG-b-PLGA与TQTCD探针在水溶液中可自组装形成均一稳定的纳米颗粒(RPP@TQTCD),并且非共价负载不影响TQTCD探针的荧光特性和光热效应。在CRGDK靶向肽的作用下,RPP@TQTCD纳米颗粒可特异性蓄积于肿瘤部位,并作用于肿瘤细胞表面高表达的神经纤毛蛋白-1(NRP-1)受体,通过受体介导的途径促进肿瘤细胞对纳米颗粒的摄取,随后在808 nm激光照射下可有效杀伤肿瘤细胞。本研究通过对疏水性探针的靶向递送,为三阴性乳腺癌(TNBC)的诊断及光热治疗提供了一种有效的策略。

English


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  • 收稿日期:  2022-03-08
  • 修回日期:  2022-04-20
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