一步法制备高导电聚3,4-乙烯二氧噻吩∶聚苯乙烯磺酸水凝胶及其电化学传感研究

崔入文 冯涛涛 高楠 张美宁

引用本文: 崔入文, 冯涛涛, 高楠, 张美宁. 一步法制备高导电聚3,4-乙烯二氧噻吩∶聚苯乙烯磺酸水凝胶及其电化学传感研究[J]. 分析化学, 2022, 50(6): 859-868. doi: 10.19756/j.issn.0253-3820.221091 shu
Citation:  CUI Ru-wen,  FENG Tao-tao,  GAO Nan,  ZHANG Mei-ning. Preparation of Conductive Poly(3,4-ethylenedioxythiophene): Poly(styrene sulfonate) Hydrogel by One-step Method for Electrochemical Sensor[J]. Chinese Journal of Analytical Chemistry, 2022, 50(6): 859-868. doi: 10.19756/j.issn.0253-3820.221091 shu

一步法制备高导电聚3,4-乙烯二氧噻吩∶聚苯乙烯磺酸水凝胶及其电化学传感研究

    通讯作者: 张美宁,E-mail:mnzhang@ruc.edu.cn
  • 基金项目:

    国家自然科学基金项目(Nos.21874152,22174162)资助。

摘要: 作为一种新型导电聚合物水凝胶材料,聚3,4-乙烯二氧噻吩∶聚苯乙烯磺酸(PEDOT∶PSS)在生物电子和生物传感领域受到越来越多的关注。然而,目前PEDOT∶PSS水凝胶的制备大多需要以非导电水凝胶为模板,或制备条件苛刻,这极大地影响了其在电化学生物传感领域的应用。本研究建立了一种简单的制备PEDOT∶PSS水凝胶的新方法,将含有乙二醇的PEDOT∶PSS水溶液经过真空干燥处理,再次吸水溶胀后即可获得稳定、具有三维交联网络的PEDOT∶PSS水凝胶。制备的PEDOT∶PSS水凝胶具有微/纳多级孔及三维导电网络结构,电导率可达到(3321.33±129.41) S/m,形貌可稳定保持2个月。PEDOT∶PSS水凝胶修饰的电极不但具有良好的异相电子转移和传质能力,而且可在一个月内有效抵抗蛋白质吸附对电化学信号的影响。水凝胶的三维网络可稳定地固载酶,并显著提高了酶电化学传感器的稳定性,酶传感器在储存1个月后的信号强度仍保持在初始信号强度的90%以上。此水凝胶为电化学传感器检测复杂生物样品提供了新的策略。

English


    1. [1]

      XIAO T, WU F, HAO J, ZHANG M, YU P, MAO L. Anal. Chem., 2017, 89(1):300-313.XIAO T, WU F, HAO J, ZHANG M, YU P, MAO L. Anal. Chem., 2017, 89(1):300-313.

    2. [2]

      JIANG Y, YANG Y, SHEN L, MA J, MA H, ZHU N. Anal. Chem., 2022, 94(1):297-311.JIANG Y, YANG Y, SHEN L, MA J, MA H, ZHU N. Anal. Chem., 2022, 94(1):297-311.

    3. [3]

      WANG L, ZHANG Q, CHEN S, XU F, CHEN S, JIA J, TAN H, HOU H, SONG Y. Anal. Chem., 2014, 86(3):1414-1421.WANG L, ZHANG Q, CHEN S, XU F, CHEN S, JIA J, TAN H, HOU H, SONG Y. Anal. Chem., 2014, 86(3):1414-1421.

    4. [4]

      LU X, CHENG H, HUANG P, YANG L, YU P, MAO L. Anal. Chem., 2013, 85(8):4007-4013.LU X, CHENG H, HUANG P, YANG L, YU P, MAO L. Anal. Chem., 2013, 85(8):4007-4013.

    5. [5]

      LI R, LIU X, QIU W, ZHANG M. Anal. Chem., 2016, 88(15):7769-7776.LI R, LIU X, QIU W, ZHANG M. Anal. Chem., 2016, 88(15):7769-7776.

    6. [6]

      DEL RIO J S, HENRY O Y F, JOLLY P, INGBER D E. Nat. Nanotechnol., 2019, 14(12):1143-1149.DEL RIO J S, HENRY O Y F, JOLLY P, INGBER D E. Nat. Nanotechnol., 2019, 14(12):1143-1149.

    7. [7]

      WANG J, LI J, LI Y, ZHANG Z, WANG L, WANG D, SU L, ZHANG X, TANG B. Chem. Sci., 2020, 11(25):6472-6478.WANG J, LI J, LI Y, ZHANG Z, WANG L, WANG D, SU L, ZHANG X, TANG B. Chem. Sci., 2020, 11(25):6472-6478.

    8. [8]

      JIANG C, WANG G, HEIN R, LIU N, LUO X, DAVIS J J. Chem. Rev., 2020, 120(8):3852-3889.JIANG C, WANG G, HEIN R, LIU N, LUO X, DAVIS J J. Chem. Rev., 2020, 120(8):3852-3889.

    9. [9]

      FENG T, JI W, ZHANG Y, WU F, TANG Q, WEI H, MAO L, ZHANG M. Angew. Chem., Int. Ed., 2020, 59(52):23445-23449.FENG T, JI W, ZHANG Y, WU F, TANG Q, WEI H, MAO L, ZHANG M. Angew. Chem., Int. Ed., 2020, 59(52):23445-23449.

    10. [10]

      FENG T, JI W, TANG Q, WEI H, ZHANG S, MAO J, ZHANG Y, MAO L, ZHANG M. Anal. Chem., 2019, 91(16):10786-10791.FENG T, JI W, TANG Q, WEI H, ZHANG S, MAO J, ZHANG Y, MAO L, ZHANG M. Anal. Chem., 2019, 91(16):10786-10791.

    11. [11]

      LIU X, XIAO T, WU F, SHEN M, ZHANG M, YU H H, MAO L. Angew. Chem., Int. Ed., 2017, 56(39):11802-11806.LIU X, XIAO T, WU F, SHEN M, ZHANG M, YU H H, MAO L. Angew. Chem., Int. Ed., 2017, 56(39):11802-11806.

    12. [12]

      ZHENG Y, HU T, CHEN C, YANG F, YANG X. Chem. Commun., 2015, 51(26):5645-5648.ZHENG Y, HU T, CHEN C, YANG F, YANG X. Chem. Commun., 2015, 51(26):5645-5648.

    13. [13]

      JENNER L P, BUTT J N. Curr. Opin. Electrochem., 2018, 8:81-88.JENNER L P, BUTT J N. Curr. Opin. Electrochem., 2018, 8:81-88.

    14. [14]

      LIN Y, YU P, HAO J, WANG Y, OHSAKA T, MAO L. Anal. Chem., 2014, 86(8):3895-3901.LIN Y, YU P, HAO J, WANG Y, OHSAKA T, MAO L. Anal. Chem., 2014, 86(8):3895-3901.

    15. [15]

      WANG X, LI Q, XU J, WU S, XIAO T, HAO J, YU P, MAO L. Anal. Chem., 2016, 88(11):5885-5891.WANG X, LI Q, XU J, WU S, XIAO T, HAO J, YU P, MAO L. Anal. Chem., 2016, 88(11):5885-5891.

    16. [16]

      LI X, YU P, YANG L, WANG F, MAO L. Anal. Chem., 2012, 84(21):9416-9421.LI X, YU P, YANG L, WANG F, MAO L. Anal. Chem., 2012, 84(21):9416-9421.

    17. [17]

      VO R, HSU H H, JIANG X. Biomater. Sci., 2021, 9(1):23-37.VO R, HSU H H, JIANG X. Biomater. Sci., 2021, 9(1):23-37.

    18. [18]

      WANG S, ZHENG H, ZHOU L, CHENG F, LIU Z, ZHANG H, WANG L, ZHANG Q. Nano Lett., 2020, 20(7):5149-5158.WANG S, ZHENG H, ZHOU L, CHENG F, LIU Z, ZHANG H, WANG L, ZHANG Q. Nano Lett., 2020, 20(7):5149-5158.

    19. [19]

      XU T, JI W, WANG X, ZHANG Y, ZENG H, MAO L, ZHANG M. Angew. Chem., Int. Ed., 2022, 61(16):e202115074XU T, JI W, WANG X, ZHANG Y, ZENG H, MAO L, ZHANG M. Angew. Chem., Int. Ed., 2022, 61(16):e202115074

    20. [20]

      WEN Y, XU J. J. Polym. Sci. Pol. Chem., 2017, 55(7):1121-1150.WEN Y, XU J. J. Polym. Sci. Pol. Chem., 2017, 55(7):1121-1150.

    21. [21]

      SMITH S K, LUGO-MORALES L Z, TANG C, GOSRANI S P, LEE C A, ROBERTS J G, MORTON S W, MCCARTY G S, KHAN S A, SOMBERS L A. ChemPhysChem, 2018, 19(10):1197-1204.SMITH S K, LUGO-MORALES L Z, TANG C, GOSRANI S P, LEE C A, ROBERTS J G, MORTON S W, MCCARTY G S, KHAN S A, SOMBERS L A. ChemPhysChem, 2018, 19(10):1197-1204.

    22. [22]

      ZHU N, ULSTRUP J, CHI Q. J. Mater. Chem. B, 2015, 3(41):8133-8142.ZHU N, ULSTRUP J, CHI Q. J. Mater. Chem. B, 2015, 3(41):8133-8142.

    23. [23]

      XU F, REN S, LI J, BI X, GU Y. Sensors, 2018, 18(6):1823.XU F, REN S, LI J, BI X, GU Y. Sensors, 2018, 18(6):1823.

    24. [24]

      ABIDIAN M R, MARTIN D C. Adv. Funct. Mater., 2009, 19(4):573-585.ABIDIAN M R, MARTIN D C. Adv. Funct. Mater., 2009, 19(4):573-585.

    25. [25]

      SHOU Wen, YANG Shuang-Ting, WANG Yue-Liang, GUO Long-Hua. Chin. J. Anal. Chem., 2021, 49(5):676-685.寿雯, 杨双婷, 王悦靓, 郭隆华.分析化学, 2021, 49(5):676-685.

    26. [26]

      WANG L, ZHANG Y, LI X, XIE Y, HE J, YU J, SONG Y. Sci. Rep., 2015, 5:14341.WANG L, ZHANG Y, LI X, XIE Y, HE J, YU J, SONG Y. Sci. Rep., 2015, 5:14341.

    27. [27]

      QIU W, XU M, LI R, LIU X, ZHANG M. Anal. Chem., 2016, 88(2):1117-1122.QIU W, XU M, LI R, LIU X, ZHANG M. Anal. Chem., 2016, 88(2):1117-1122.

    28. [28]

      FEIG V R, TRAN H, LEE M, LIU K, HUANG Z, BEKER L, MACKANIC D G, BAO Z. Adv. Mater., 2019, 31(39):1902869.FEIG V R, TRAN H, LEE M, LIU K, HUANG Z, BEKER L, MACKANIC D G, BAO Z. Adv. Mater., 2019, 31(39):1902869.

    29. [29]

      YAO B, WANG H, ZHOU Q, WU M, ZHANG M, LI C, SHI G. Adv. Mater., 2017, 29(28):1700974.YAO B, WANG H, ZHOU Q, WU M, ZHANG M, LI C, SHI G. Adv. Mater., 2017, 29(28):1700974.

    30. [30]

      LU B, YUK H, LIN S, JIAN N, QU K, XU J, ZHAO X. Nat. Commun., 2019, 10:1043.LU B, YUK H, LIN S, JIAN N, QU K, XU J, ZHAO X. Nat. Commun., 2019, 10:1043.

    31. [31]

      OUYANG J, XU Q, CHU C, YANG Y, LI G, SHINAR J. Polymer, 2004, 45(25):8443-8450.OUYANG J, XU Q, CHU C, YANG Y, LI G, SHINAR J. Polymer, 2004, 45(25):8443-8450.

    32. [32]

      ZHANG Shuai, FENG Tao-Tao, ZHANG Li, ZHANG Mei-Ning. Chin. J. Anal. Chem., 2019, 47(10):1664-1670.张帅, 冯涛涛, 张丽, 张美宁.分析化学, 2019, 47(10):1664-1670.

    33. [33]

      SHI H, LIU C, JIANG Q, XU J. Adv. Electron. Mater., 2015, 1(4):1500017.SHI H, LIU C, JIANG Q, XU J. Adv. Electron. Mater., 2015, 1(4):1500017.

    34. [34]

      PAN L, YU G, ZHAI D, LEE H R, ZHAO W, LIU N, WANG H, TEE B C K, SHI Y, CUI Y, BAO Z. Proc. Natl.Acad. Sci. U. S. A., 2012, 109(24):9287-9292.PAN L, YU G, ZHAI D, LEE H R, ZHAO W, LIU N, WANG H, TEE B C K, SHI Y, CUI Y, BAO Z. Proc. Natl.Acad. Sci. U. S. A., 2012, 109(24):9287-9292.

    35. [35]

      ZHAI D, LIU B, SHI Y, PAN L, WANG Y, LI W, ZHANG R, YU G. ACS Nano, 2013, 7(4):3540-3546.ZHAI D, LIU B, SHI Y, PAN L, WANG Y, LI W, ZHANG R, YU G. ACS Nano, 2013, 7(4):3540-3546.

    36. [36]

      MA C, ZHANG Y, LIU Q, DU Y, WANG E. Anal. Chem., 2020, 92(7):5319-5328.MA C, ZHANG Y, LIU Q, DU Y, WANG E. Anal. Chem., 2020, 92(7):5319-5328.

    37. [37]

      LIN Y, LIU K, YU P, XIANG L, LI X, MAO L. Anal. Chem., 2007, 79(24):9577-9583.LIN Y, LIU K, YU P, XIANG L, LI X, MAO L. Anal. Chem., 2007, 79(24):9577-9583.

    38. [38]

      WANG J, WANG Y, CUI M, XU S, LUO X. Microchim. Acta, 2017, 184(2):483-489.WANG J, WANG Y, CUI M, XU S, LUO X. Microchim. Acta, 2017, 184(2):483-489.

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  • 收稿日期:  2022-02-22
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