微针在皮肤间质液生物分析中的研究进展

卢惠婷 李金泽 王夜宇 葛如娇 董海峰

引用本文: 卢惠婷, 李金泽, 王夜宇, 葛如娇, 董海峰. 微针在皮肤间质液生物分析中的研究进展[J]. 分析化学, 2022, 50(6): 819-829,858. doi: 10.19756/j.issn.0253-3820.221013 shu
Citation:  LU Hui-Ting,  LI Jin-Ze,  WANG Ye-Yu,  GE Ru-Jiao,  DONG Hai-Feng. Research Progress of Microneedles in Interstitial Fluid Bioanalysis[J]. Chinese Journal of Analytical Chemistry, 2022, 50(6): 819-829,858. doi: 10.19756/j.issn.0253-3820.221013 shu

微针在皮肤间质液生物分析中的研究进展

    通讯作者: 李金泽,E-mail:lijinze15102654572@163.com; 董海峰,E-mail:hfdong@ustb.edu.cn
  • 基金项目:

    国家自然科学基金项目(Nos.21874008,22004006,22022407,21890740,21890742)、国家重大研究计划专项基金项目(No.2019YFC1606603)和深圳大学2021年稳定支持计划项目(No.8940206/0200)资助。

摘要: 对生物样品进行采集并分析测定是疾病诊断和治疗的有效手段,其中,血液取样和分析是临床诊断中的标准方法,但血液采样具有损伤性,通常会导致皮肤组织损伤从而引起患者不适。皮肤间质液(Interstitial skin fluid,ISF)具有丰富的生物学信息,是一种很有前景的血液替代品,然而,以微创和非侵入性方式采集ISF中足够的标志物仍然具有很大的挑战。近年来,微针(Microneedles,MNs)技术因其具有高效、安全、方便和无痛等特点,在ISF研究中备受关注。MNs作为一种微米级别的针阵列,在医疗美容、分子递送、诊断监测以及疾病治疗等方面取得了显著的成果,但在ISF生物分析中的应用很少。本文总结了制备MNs的材料,详细描述了MNs在ISF采样、生物标志物捕获和分析以及可穿戴传感等方面的应用,展望了MNs作为一个新兴研究领域的发展前景,并总结了在技术成果转化过程中需要考虑和存在的问题。

English


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