Citation: JIN Ze-Hui, MIN Qian-Hao. Advances in Nanomaterials Facilitated Mass Spectrometry Imaging[J]. Chinese Journal of Analytical Chemistry, ;2021, 49(7): 1176-1187. doi: 10.19756/j.issn.0253-3820.211073 shu

Advances in Nanomaterials Facilitated Mass Spectrometry Imaging

JIN Ze-Hui ,
MIN Qian-Hao ^,

State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China

Corresponding author: MIN Qian-Hao, minqianhao@nju.edu.cn
Received Date: 26 January 2021
Revised Date: 3 April 2021

Fund Project: Supported by the National Natural Science Foundation of China (Nos. 21622505, 21974062).

Diversified composition and tailorable properties of nanomaterials have provided infinite possibilities for the development of mass spectrometric methods. With the blooming innovation of mass spectrometry technology in recent years, researchers have begun to expand the application of nanomaterials-assisted mass spectrometry from mere detection to imaging. By using nanomaterials as matrices for assisting desorption/ionization or carriers of signal molecules, mass spectrometry imaging can not only provide molecular information of unknown compounds, but also achieve accurate profiling of spatial distribution of biomolecules, drugs, environmental pollutants and other target molecules in tissues and even single cells, thus providing a more intuitive means for physiology and pathology study at tissue or cell level. In this review, the main principles and research progress of nanomaterials facilitated mass spectrometry imaging are summarized, and its future development and potential applications are also prospected.
- Mass spectrometry imaging,
- Nanomaterials,
- Laser desorption/ionization,
- Secondary ion mass spectrometry,
- Review
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