人体呼出挥发性有机物的口罩微萃取气相色谱-质谱分析

陈伟妮 袁子程 蔡深回 邹颖通 辛国斌 狄丹丹 宋昕 赵鹏 吴曼曼 胡斌

引用本文: 陈伟妮, 袁子程, 蔡深回, 邹颖通, 辛国斌, 狄丹丹, 宋昕, 赵鹏, 吴曼曼, 胡斌. 人体呼出挥发性有机物的口罩微萃取气相色谱-质谱分析[J]. 分析化学, 2022, 50(3): 445-453. doi: 10.19756/j.issn.0253-3820.210828 shu
Citation:  CHEN Wei-Ni,  YUAN Zi-Cheng,  CAI Shen-Hui,  ZOU Ying-Tong,  XIN Guo-Bin,  DI Dan-Dan,  SONG Xin,  ZHAO Peng,  WU Man-Man,  HU Bin. Gas Chromatography-Mass Spectrometry Analysis of Human Exhaled Volatile Organic Compounds via Wearable Facemask Microextraction Sampling[J]. Chinese Journal of Analytical Chemistry, 2022, 50(3): 445-453. doi: 10.19756/j.issn.0253-3820.210828 shu

人体呼出挥发性有机物的口罩微萃取气相色谱-质谱分析

    通讯作者: 吴曼曼,E-mail:mm.wu@hxmass.com; 胡斌,E-mail:bin.hu@jnu.edu.cn
  • 基金项目:

    国家自然科学基金项目(No.21804053)和法庭毒物分析公安部重点实验室(北京市公安局)开放基金项目(No.2021FTDWFX03)资助。

摘要: 人体呼气中含有大量与人类行为和健康状况有关的挥发性有机物(VOCs)。本研究采用口罩微萃取方法富集人体呼出VOCs,并联用3种气相色谱-质谱仪(GC-MS)对呼出VOCs进行分析鉴定与比对。优化了固相微萃取探针及富集采样时间;通过对比正常生理呼出VOCs和口罩的背景信号,探索了人体经过不同的食物摄入和口腔护理对呼出VOCs的影响,以及特征VOCs的可检测性和持续性;对比了常规、便携式和全二维GC-MS仪器对人体呼出VOCs的分析性能与特性。结果表明,口罩微萃取气相色谱-质谱方法可有效地检测口腔中大量的内源性和外源性挥发VOCs,并且具有采样安全简便、高效便捷、与不同仪器的适配性强等特点,为人体口腔健康与疾病诊断提供了新方法。

English


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  • 收稿日期:  2021-11-05
  • 修回日期:  2022-01-04
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