Citation: CAI Dong-Ming, OUYANG Jie, DING Jin-Jian, LIN Min, ZHANG Wei-Wei, LI Min-Jie, GUO Liang-Hong. Research Progress on Identification and Toxic Effects of Antibiotics Disinfection By-products[J]. Chinese Journal of Analytical Chemistry, ;2022, 50(3): 327-340. doi: 10.19756/j.issn.0253-3820.210811 shu

Research Progress on Identification and Toxic Effects of Antibiotics Disinfection By-products

CAI Dong-Ming ^1,2 ,
OUYANG Jie ^2,3 ,
DING Jin-Jian ^2,3 ,
LIN Min ⁴ ,
ZHANG Wei-Wei ⁴ ,
LI Min-Jie ^3,, ,
GUO Liang-Hong ^2,3,,

¹College of Life Sciences, China Jiliang University, Hangzhou 310018, China;
²Institute of Environmental and Health Sciences, China Jiliang University, Hangzhou 310018, China;
³College of Quality and Safety Engineering, China Jiliang University, Hangzhou 310018, China;
⁴Hangzhou Jasu Environmental Monitoring Co., Ltd., Hangzhou 310018, China

Corresponding author: LI Min-Jie, GUO Liang-Hong,
Received Date: 25 October 2021
Revised Date: 31 December 2021

Fund Project: Supported by the National Natural Science Foundation of China (Nos.U20A20133, 21878302).

Due to extensive use and persistent discharge, the environmental levels of antibiotics have been increasing over time. The concentrations of some antibiotics in surface water have reached 300 ng/L, while those in drinking water sources have exceeded 200 ng/L. During disinfection process of drinking water, the antibiotics react with the disinfectants to produce a variety of by-products, some of which are carcinogenic or acutely toxic. These antibiotic disinfection by-products (DBPs) pose direct threat to human health, and thus become the frontier research topic in environmental health science. Based on the studies mostly published in the recent years, this review summarized the analytical methods of DBPs from five major categories of antibiotics (Chloramphenicols, sulfanilamides, fluoroquinolones, tetracyclines, macrolides) including sample pretreatment, chromatography separation and spectroscopic and mass spectrometry detection. Identified DBPs under specific disinfection conditions were then described according to the category of the antibiotics. Furthermore, common toxicity test methods including luminescent bacteria inhibition were introduced, and the test results of some antibiotic DBPs were described. A variety of antibiotic DBPs were identified in previous studies, and some of them were shown to be more toxic than their precursors and thus deserved further investigation.
- Antibiotics,
- Disinfection by-products,
- Analytical methods,
- Toxicity tests,
- Review
1. [1]
  https://www.chyxx.com/industry/202107/961106.html.
2. [2]
  VAN BOECKELA T P, BROWERB C, GILBERT M, GRENFELL B T, LEVIN S A, ROBINSON T P, TEILLANT A, LAXMINARAYAN R. Proc. Natl. Acad. Sci. U.S.A., 2015, 112(18):5649-5654.
3. [3]
  KUMMERER K, HENNINGER A. Clin. Microbiol. Infect., 2003, 9(12):1203-1214.
4. [4]
  ZHOU L J, YING G G, LIU S, ZHANG R Q, LAI H J, CHEN Z F, PAN C G. Sci. Total Environ., 2013, 444:183-195.
5. [5]
6. [6]
7. [7]
8. [8]
  DING S K, CHU W H. Trends Environ. Anal. Chem., 2017, 14:19-27.
9. [9]
  CHU W H, KRASNER S W, GAO N Y, TEMPLETON M R, YIN D Q. Environ. Sci. Technol., 2016, 50(1):388-396.
10. [10]
  GAFFNEY V D, CARDOSO V V, BENOLIEL M J, ALMEIDA C M M. J. Environ. Manage., 2016, 166:466-477.
11. [11]
  El NAJJAR N H, DEBORDE M, JOURNEL R, LEITNER N K V. Water Res., 2013, 47(1):121-129.
12. [12]
  LEAVEY-ROBACK S L, KRASNER S W, SUFFET I H. Chemosphere, 2016, 164:330-338.
13. [13]
  ZHANG Y Y, PAN Z H, RONG C, SHAO Y A, WANG Y H, YU K F. Sep. Purif. Technol., 2019, 212:528-535.
14. [14]
  SHEN R Q, ANDREWS S A. Water Res., 2011, 45(2):944-952.
15. [15]
  DONG H Y, QIANG Z M, HU J, QU J H. Water Res., 2017, 121:178-185.
16. [16]
17. [17]
  YE Z X, SHAO K L, HUANG H, YANG X. Chemosphere, 2021, 270:128628.
18. [18]
  LI S, MA J P, WU G G, LI J H, WANG X Y, CHEN L X. J. Hazard. Mater., 2021, 424:127687.
19. [19]
  ZHANG Y M, CHU W H, XU T, YIN D Q, XU B, LI P, AN N. Chem. Eng. J., 2017, 317:112-118.
20. [20]
  CHU W H, CHU T F, BOND T, DU E D, GUO Y Q, GAO N Y. Water Res., 2016, 93:48-55.
21. [21]
  WANG M, HELBLING D E. Water Res., 2016, 102:241-251.
22. [22]
  KHANA M H, BAEA H, JUNG J Y. J. Hazard. Mater., 2010, 181(1-3):659-665.
23. [23]
  LI C, LUO F, DUAN H J, DONG F L, CHEN X Y, FENG M B, ZHANG Z R, CIZMAS L, SHARMA V K. Sep. Purif. Technol., 2019, 211:564-570.
24. [24]
  RODAYAN A, ROY R, YARGEAU V. J. Hazard. Mater., 2010, 177(1-3):237-243.
25. [25]
  WANG H L, SHI W Y, MA D F, SHANG Y A, WANG Y, GAO B Y. Chem. Eng. J., 2020, 392:123701.
26. [26]
27. [27]
  DE WITTE B, VAN LANGENHOVE H, HEMELSOET K, DEMEESTERE K, DE WISPELAERE P, VAN SPEYBROECK V, DEWULF J. Chemosphere, 2009, 76(5):683-689.
28. [28]
  DEWITTE B, DEWULF J, DEMEESTERE K, DE VYVEREN V V, DE WISPELAERE P, VAN LANGENHOVE H. Environ. Sci. Technol., 2008, 42(13):4889-4895.
29. [29]
  ZHOU S Q, SHAO Y S, GAO N Y, ZHU S M, MA Y, DENG J. Ecotoxicol. Environ. Saf., 2014, 107:33-35.
30. [30]
  SHAO K L, YE Z X, HUANGA H, YANG X. Water Res., 2020, 186:116313.
31. [31]
  JAEN-GIL A, FARRE M J, SÁNCHEZ-MELSIÓ A, SERRA-COMPTE A, BARCELÓ D, RODRÍGUEZ-MOZAZ S. Environ. Sci. Technol., 2020, 54(14):9062-9073.
32. [32]
  LUIZ D B, GENENA A K, VIRMOND E, JOSE H J, MOREIRA R F P M, GEBHARDT W, SCHRÖDER H F. Water Environ. Res., 2010, 82(9):797-805.
33. [33]
  YANG Y J, SHI J C, YANG Y, YIN J, ZHANG J, SHAO B. J. Environ. Sci., 2019, 76:48-56.
34. [34]
  WANG G Q, SHI W Y, MA D F, GAO B Y. Sci. Total Environ., 2020, 731:138755.
35. [35]
  MIYASHIRO T, RUBY E G. Mol. Microbiol., 2012, 84(5):795-806.
36. [36]
  ABBASA M, ADIL M, EHTISHAM-UL-HAQUE S, MUNIR B, YAMMEN M, GHAFFAR A, SHAR G A, TAHIR M A, IQBAL M. Sci. Total Environ., 2018, 626:1295-1309.
37. [37]
  ZHANG T Q, HE G L, DONG F L, ZHANG Q Z, HUANG Y. Sci. Total Environ., 2019, 676:31-39.
38. [38]
  MÉDICE R M, AFONSO R G D F, ALMEIDA M L B, DE AQUINO S F, LIBÂNIO M. Environ. Sci. Pollut. Res., 2020, 28(4):3828-3836.
39. [39]
  MOE B, GABOS S, LI X F. Anal. Chim. Acta, 2013, 789:83-90.
40. [40]
  FENG Y X, GUO Q Z, SHAO B. Ecotoxicol. Environ. Saf., 2019, 182:109415.
41. [41]
  ABELLÁN M N, GEBHARDT W, SCHRÖDER H F. Water Sci. Technol., 2008, 58(9):1803-1812.
42. [42]
  CHEN B Y, ZHANG T, BOND T, GAN Y Q. J. Hazard. Mater., 2015, 299:260-279.
43. [43]
  GUO Q Z, DU Z X, SHAO B. J. Hazard. Mater., 2018, 359:31-39.
44. [44]
  FU W J, LI B, YANG J Q, YI H B, CHAI L Y, LI X Y. Chem. Eng. J., 2018, 331:785-793.
45. [45]
  LI M, WEI D B, DU Y G. J. Environ. Sci., 2014, 26(9):1837-1842.
46. [46]
  HE G L, ZHANG T Q, ZHENG F F, LI C, ZHANG Q Z, DONG F L, HUANG Y. Chem. Eng. J., 2019, 374:1191-1203.
47. [47]
  YIN K, DENG L, LUO J M, CRITTENDEN J, LIU C B, WEI Y F, WANG L L. Chem. Eng. J., 2018, 351:867-877.
48. [48]
  CAI A H, DENG J, XU M Y, ZHU T X, ZHOU S Q, LI J, WANG G F, LI X Y. Chem. Eng. J., 2020, 395:125090.
49. [49]
  DONG H Y, CUTHBERTSON A A, RICHARDSON S D. Environ. Sci. Technol., 2020, 54(3):1290-1292.
1. [1]
  Jijun Sun , Qianlang Wang , Qian Chen , Quanqin Zhao , Shumei Zhai . The Antibiotic Legion’s Manifesto to Human Allies. University Chemistry, 2025, 40(4): 307-321. doi: 10.12461/PKU.DXHX202405206
2. [2]
  Yongzhi LI , Han ZHANG , Gangding WANG , Yanwei SUI , Lei HOU , Yaoyu WANG . A two-dimensional metal-organic framework for the determination of nitrofurantoin and nitrofurazone in aqueous solution. Chinese Journal of Inorganic Chemistry, 2025, 41(2): 245-253. doi: 10.11862/CJIC.20240307
3. [3]
  Peiling Li , Qing Feng , Hongling Yuan , Qin Wang . Live Interview Recording about the Penicillin Family. University Chemistry, 2024, 39(9): 122-127. doi: 10.3866/PKU.DXHX202311022
4. [4]
  Ziheng Zhuang , Xiao Xu , Kin Shing Chan . Superdrugs for Superbugs. University Chemistry, 2024, 39(9): 128-133. doi: 10.3866/PKU.DXHX202309040
5. [5]
  Chengyi Xiao , Xiaoli Sun , Chen Zhang , Weiwei Li . An In-Depth Analysis of the Scientific Connotations, Testing Methods, and Applications of Free Volume in Polymer Physics. University Chemistry, 2025, 40(4): 33-45. doi: 10.12461/PKU.DXHX202403069
6. [6]
  Shijie Li , Ke Rong , Xiaoqin Wang , Chuqi Shen , Fang Yang , Qinghong Zhang . Design of Carbon Quantum Dots/CdS/Ta₃N₅ S-Scheme Heterojunction Nanofibers for Efficient Photocatalytic Antibiotic Removal. Acta Physico-Chimica Sinica, 2024, 40(12): 2403005-. doi: 10.3866/PKU.WHXB202403005
7. [7]
  Wenda WANG , Jinku MA , Yuzhu WEI , Shuaishuai MA . Waste biomass-derived carbon modified porous graphite carbon nitride heterojunction for efficient photodegradation of oxytetracycline in seawater. Chinese Journal of Inorganic Chemistry, 2024, 40(4): 809-822. doi: 10.11862/CJIC.20230353
8. [8]
  Kexin Dong , Chuqi Shen , Ruyu Yan , Yanping Liu , Chunqiang Zhuang , Shijie Li . Integration of Plasmonic Effect and S-Scheme Heterojunction into Ag/Ag₃PO₄/C₃N₅ Photocatalyst for Boosted Photocatalytic Levofloxacin Degradation. Acta Physico-Chimica Sinica, 2024, 40(10): 2310013-. doi: 10.3866/PKU.WHXB202310013
9. [9]
  Hongwei Ma , Hui Li . Three Methods for Structure Determination from Powder Diffraction Data. University Chemistry, 2024, 39(3): 94-102. doi: 10.3866/PKU.DXHX202310035
10. [10]
  Feng Liang , Desheng Li , Yuting Jiang , Jiaxin Dong , Dongcheng Liu , Xingcan Shen . Method Exploration and Instrument Innovation for the Experiment of Colloid ζ Potential Measurement by Electrophoresis. University Chemistry, 2024, 39(5): 345-353. doi: 10.3866/PKU.DXHX202312009
11. [11]
  Yuting Zhang , Zhiqian Wang . Methods and Case Studies for In-Depth Learning of the Aldol Reaction Based on Its Reversible Nature. University Chemistry, 2024, 39(7): 377-380. doi: 10.3866/PKU.DXHX202311037
12. [12]
  Sifang Zhang , Yanli Tan , Yu Tao , Jiaoyan Zhao , Haihong Zhu . Exploration and Practice of Ideological and Political Cases in the Course of Chemistry History and Methodology. University Chemistry, 2024, 39(10): 377-388. doi: 10.12461/PKU.DXHX202312067
13. [13]
  Yuyang Xu , Ruying Yang , Yanzhe Zhang , Yandong Liu , Keyi Li , Zehui Wei . Research Progress of Aflatoxins Removal by Modern Optical Methods. University Chemistry, 2024, 39(11): 174-181. doi: 10.12461/PKU.DXHX202402064
14. [14]
  Hongting Yan , Aili Feng , Rongxiu Zhu , Lei Liu , Dongju Zhang . Reexamination of the Iodine-Catalyzed Chlorination Reaction of Chlorobenzene Using Computational Chemistry Methods. University Chemistry, 2025, 40(3): 16-22. doi: 10.12461/PKU.DXHX202403010
15. [15]
  Xingyuan Lu , Yutao Yao , Junjing Gu , Peifeng Su . Energy Decomposition Analysis and Its Application in the Many-Body Effect of Water Clusters. University Chemistry, 2025, 40(3): 100-107. doi: 10.12461/PKU.DXHX202405074
16. [16]
  Yu'ang Liu , Yuechao Wu , Junyu Huang , Tao Wang , Xiaohong Liu , Tianying Yan . Computation of Absolute Electrode Potential of Standard Hydrogen Electrode Using Ab Initio Method. University Chemistry, 2025, 40(3): 215-222. doi: 10.12461/PKU.DXHX202407112
17. [17]
  Qilong Fang , Yiqi Li , Jiangyihui Sheng , Quan Yuan , Jie Tan . Magical Pesticide Residue Detection Test Strips: Aptamer-based Lateral Flow Test Strips for Organophosphorus Pesticide Detection. University Chemistry, 2024, 39(5): 80-89. doi: 10.3866/PKU.DXHX202310004
18. [18]
  Jingfeng Lan , Li Wu , Guangnong Lu , Liu Yang , Xiaolong Li , Xiangyang Xu , Yongwen Shen , E Yu . Application of 3E Method in the Negative List Management System in Teaching Laboratory. University Chemistry, 2024, 39(4): 54-61. doi: 10.3866/PKU.DXHX202310130
19. [19]
  Haiping Wang . A Streamlined Method for Drawing Lewis Structures Using the Valence State of Outer Atoms. University Chemistry, 2024, 39(8): 383-388. doi: 10.12461/PKU.DXHX202401073
20. [20]
  Yang Chen , Peng Chen , Yuyang Song , Yuxue Jin , Song Wu . Application of Chemical Transformation Driven Impurity Separation in Experiments Teaching: A Novel Method for Purification of α-Fluorinated Mandelic Acid. University Chemistry, 2024, 39(6): 253-263. doi: 10.3866/PKU.DXHX202310077

Get Citation

PDF

XML

Metrics

PDF Downloads(18)
Abstract views(1127)
HTML views(331)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142