抗生素消毒副产物的分析检测及毒性效应研究进展

引用本文: 蔡东明, 欧阳洁, 丁锦建, 林敏, 章维维, 李敏杰, 郭良宏. 抗生素消毒副产物的分析检测及毒性效应研究进展[J]. 分析化学, 2022, 50(3): 327-340. doi: 10.19756/j.issn.0253-3820.210811 shu

Citation: CAI Dong-Ming, OUYANG Jie, DING Jin-Jian, LIN Min, ZHANG Wei-Wei, LI Min-Jie, GUO Liang-Hong. Research Progress on Identification and Toxic Effects of Antibiotics Disinfection By-products[J]. Chinese Journal of Analytical Chemistry, 2022, 50(3): 327-340. doi: 10.19756/j.issn.0253-3820.210811 shu

抗生素消毒副产物的分析检测及毒性效应研究进展

蔡东明 ^1,2, ,
欧阳洁 ^2,3, ,
丁锦建 ^2,3, ,
林敏 ^4, ,
章维维 ^4, ,
李敏杰 ^{3,
,} ,
郭良宏 ^{2,3,
,}

¹中国计量大学生命科学学院, 杭州 310018;
²中国计量大学环境与健康科学研究院, 杭州 310018;
³中国计量大学质量与安全工程学院, 杭州 310018;
⁴杭州嘉澍环境监测有限公司, 杭州 310018

通讯作者: 李敏杰,E-mail:mjli@cjlu.edu.cn; 郭良宏,E-mail:lhguo@cjlu.edu.cn

基金项目:
国家自然科学基金项目（Nos.U20A20133，21878302）和中国科学院生态环境研究中心中国科学院环境生物技术重点实验室开放课题项目（No.kf2020007）资助。

摘要: 由于抗生素的大量使用和持续排放，其环境污染水平逐年升高，个别抗生素在地表水中浓度接近300 ng/L，在饮用水原水中浓度超过200 ng/L。在饮用水消毒过程中，抗生素会与消毒剂反应生成不同种类的消毒副产物（DBPs），其中一些副产物具有较高的致癌性和急性毒性。饮用水中的抗生素DBPs可危害人体健康，是环境健康科学研究的重要方向之一。本文基于近年文献报道，针对5类常见抗生素（氯霉素类、磺胺类、氟喹诺酮类、四环素类和大环内酯类）的DBPs，首先总结归纳了包括样品前处理、色谱分离和光谱、质谱检测的DBPs分析鉴定方法；然后，按照抗生素类别，概述了特定消毒条件下检测发现的DBPs种类；最后，介绍了包括发光菌抑制法的常见毒性测试方法，以及一些DBPs的毒性评估结果。目前已经发现的抗生素DBPs种类多、数量大，其中一些副产物的毒性显著高于前驱体，有必要开展深入研究。

关键词:

English

Research Progress on Identification and Toxic Effects of Antibiotics Disinfection By-products

¹College of Life Sciences, China Jiliang University, Hangzhou 310018, China;
²Institute of Environmental and Health Sciences, China Jiliang University, Hangzhou 310018, China;
³College of Quality and Safety Engineering, China Jiliang University, Hangzhou 310018, China;
⁴Hangzhou Jasu Environmental Monitoring Co., Ltd., Hangzhou 310018, China

Corresponding author: LI Min-Jie, ; GUO Liang-Hong,

Received Date: 25 October 2021
Revised Date: 31 December 2021
Fund Project:
Supported by the National Natural Science Foundation of China (Nos.U20A20133, 21878302).

Abstract: Due to extensive use and persistent discharge, the environmental levels of antibiotics have been increasing over time. The concentrations of some antibiotics in surface water have reached 300 ng/L, while those in drinking water sources have exceeded 200 ng/L. During disinfection process of drinking water, the antibiotics react with the disinfectants to produce a variety of by-products, some of which are carcinogenic or acutely toxic. These antibiotic disinfection by-products (DBPs) pose direct threat to human health, and thus become the frontier research topic in environmental health science. Based on the studies mostly published in the recent years, this review summarized the analytical methods of DBPs from five major categories of antibiotics (Chloramphenicols, sulfanilamides, fluoroquinolones, tetracyclines, macrolides) including sample pretreatment, chromatography separation and spectroscopic and mass spectrometry detection. Identified DBPs under specific disinfection conditions were then described according to the category of the antibiotics. Furthermore, common toxicity test methods including luminescent bacteria inhibition were introduced, and the test results of some antibiotic DBPs were described. A variety of antibiotic DBPs were identified in previous studies, and some of them were shown to be more toxic than their precursors and thus deserved further investigation.

Key words:

1. [1]
  https://www.chyxx.com/industry/202107/961106.html.https://www.chyxx.com/industry/202107/961106.html.
2. [2]
  VAN BOECKELA T P, BROWERB C, GILBERT M, GRENFELL B T, LEVIN S A, ROBINSON T P, TEILLANT A, LAXMINARAYAN R. Proc. Natl. Acad. Sci. U.S.A., 2015, 112(18):5649-5654.VAN BOECKELA T P, BROWERB C, GILBERT M, GRENFELL B T, LEVIN S A, ROBINSON T P, TEILLANT A, LAXMINARAYAN R. Proc. Natl. Acad. Sci. U.S.A., 2015, 112(18):5649-5654.
3. [3]
  KUMMERER K, HENNINGER A. Clin. Microbiol. Infect., 2003, 9(12):1203-1214.KUMMERER K, HENNINGER A. Clin. Microbiol. Infect., 2003, 9(12):1203-1214.
4. [4]
  ZHOU L J, YING G G, LIU S, ZHANG R Q, LAI H J, CHEN Z F, PAN C G. Sci. Total Environ., 2013, 444:183-195.ZHOU L J, YING G G, LIU S, ZHANG R Q, LAI H J, CHEN Z F, PAN C G. Sci. Total Environ., 2013, 444:183-195.
5. [5]
  ZHANG Qiang, XIN Qi, ZHU Jing-Min, CHENG Jin-Ping. Environ. Chem., 2014, 33(7):1075-1083. 章强, 辛琦, 朱静敏, 程金平. 环境化学, 2014, 33(7):1075-1083.
6. [6]
  LIU Xi, WANG Zhi, WANG Xue-Lei, LI Zhen, YANG Chao, LI En-Hua, WEI Hui-Min. Environ. Sci., 2019, 40(5):2094-2100. 刘昔, 王智, 王学雷, 李珍, 杨超, 厉恩华, 位慧敏. 环境科学, 2019, 40(5):2094-2100.
7. [7]
  LEI Yu-Yang, LI Fang-Fang, OUYANG Jie, LI Min-Jie, GUO Liang-Hong. Prog. Chem., 2021, 33(8):1414-1425. 雷雨洋, 李方方, 欧阳洁, 李敏杰, 郭良宏. 化学进展, 2021, 33(8):1414-1425.
8. [8]
  DING S K, CHU W H. Trends Environ. Anal. Chem., 2017, 14:19-27.DING S K, CHU W H. Trends Environ. Anal. Chem., 2017, 14:19-27.
9. [9]
  CHU W H, KRASNER S W, GAO N Y, TEMPLETON M R, YIN D Q. Environ. Sci. Technol., 2016, 50(1):388-396.CHU W H, KRASNER S W, GAO N Y, TEMPLETON M R, YIN D Q. Environ. Sci. Technol., 2016, 50(1):388-396.
10. [10]
  GAFFNEY V D, CARDOSO V V, BENOLIEL M J, ALMEIDA C M M. J. Environ. Manage., 2016, 166:466-477.GAFFNEY V D, CARDOSO V V, BENOLIEL M J, ALMEIDA C M M. J. Environ. Manage., 2016, 166:466-477.
11. [11]
  El NAJJAR N H, DEBORDE M, JOURNEL R, LEITNER N K V. Water Res., 2013, 47(1):121-129.El NAJJAR N H, DEBORDE M, JOURNEL R, LEITNER N K V. Water Res., 2013, 47(1):121-129.
12. [12]
  LEAVEY-ROBACK S L, KRASNER S W, SUFFET I H. Chemosphere, 2016, 164:330-338.LEAVEY-ROBACK S L, KRASNER S W, SUFFET I H. Chemosphere, 2016, 164:330-338.
13. [13]
  ZHANG Y Y, PAN Z H, RONG C, SHAO Y A, WANG Y H, YU K F. Sep. Purif. Technol., 2019, 212:528-535.ZHANG Y Y, PAN Z H, RONG C, SHAO Y A, WANG Y H, YU K F. Sep. Purif. Technol., 2019, 212:528-535.
14. [14]
  SHEN R Q, ANDREWS S A. Water Res., 2011, 45(2):944-952.SHEN R Q, ANDREWS S A. Water Res., 2011, 45(2):944-952.
15. [15]
  DONG H Y, QIANG Z M, HU J, QU J H. Water Res., 2017, 121:178-185.DONG H Y, QIANG Z M, HU J, QU J H. Water Res., 2017, 121:178-185.
16. [16]
  NI Xian-Zhe, WANG Gang, ZHOU Cai-Yun, GUI Bo, YAO Wei-Hao. China Water Wastewater, 2019, 35(5):48-54. 倪先哲, 王刚, 周彩云, 桂波, 姚维昊. 中国给水排水, 2019, 35(5):48-54.
17. [17]
  YE Z X, SHAO K L, HUANG H, YANG X. Chemosphere, 2021, 270:128628.YE Z X, SHAO K L, HUANG H, YANG X. Chemosphere, 2021, 270:128628.
18. [18]
  LI S, MA J P, WU G G, LI J H, WANG X Y, CHEN L X. J. Hazard. Mater., 2021, 424:127687.LI S, MA J P, WU G G, LI J H, WANG X Y, CHEN L X. J. Hazard. Mater., 2021, 424:127687.
19. [19]
  ZHANG Y M, CHU W H, XU T, YIN D Q, XU B, LI P, AN N. Chem. Eng. J., 2017, 317:112-118.ZHANG Y M, CHU W H, XU T, YIN D Q, XU B, LI P, AN N. Chem. Eng. J., 2017, 317:112-118.
20. [20]
  CHU W H, CHU T F, BOND T, DU E D, GUO Y Q, GAO N Y. Water Res., 2016, 93:48-55.CHU W H, CHU T F, BOND T, DU E D, GUO Y Q, GAO N Y. Water Res., 2016, 93:48-55.
21. [21]
  WANG M, HELBLING D E. Water Res., 2016, 102:241-251.WANG M, HELBLING D E. Water Res., 2016, 102:241-251.
22. [22]
  KHANA M H, BAEA H, JUNG J Y. J. Hazard. Mater., 2010, 181(1-3):659-665.KHANA M H, BAEA H, JUNG J Y. J. Hazard. Mater., 2010, 181(1-3):659-665.
23. [23]
  LI C, LUO F, DUAN H J, DONG F L, CHEN X Y, FENG M B, ZHANG Z R, CIZMAS L, SHARMA V K. Sep. Purif. Technol., 2019, 211:564-570.LI C, LUO F, DUAN H J, DONG F L, CHEN X Y, FENG M B, ZHANG Z R, CIZMAS L, SHARMA V K. Sep. Purif. Technol., 2019, 211:564-570.
24. [24]
  RODAYAN A, ROY R, YARGEAU V. J. Hazard. Mater., 2010, 177(1-3):237-243.RODAYAN A, ROY R, YARGEAU V. J. Hazard. Mater., 2010, 177(1-3):237-243.
25. [25]
  WANG H L, SHI W Y, MA D F, SHANG Y A, WANG Y, GAO B Y. Chem. Eng. J., 2020, 392:123701.WANG H L, SHI W Y, MA D F, SHANG Y A, WANG Y, GAO B Y. Chem. Eng. J., 2020, 392:123701.
26. [26]
  GUO Hong-Guang, LIU Hong-Wei, ZHANG Yong-Li. Water Purif. Technol., 2016, 35(1):38-42. 郭洪光, 刘洪位, 张永丽. 净水技术, 2016, 35(1):38-42.
27. [27]
  DE WITTE B, VAN LANGENHOVE H, HEMELSOET K, DEMEESTERE K, DE WISPELAERE P, VAN SPEYBROECK V, DEWULF J. Chemosphere, 2009, 76(5):683-689.DE WITTE B, VAN LANGENHOVE H, HEMELSOET K, DEMEESTERE K, DE WISPELAERE P, VAN SPEYBROECK V, DEWULF J. Chemosphere, 2009, 76(5):683-689.
28. [28]
  DEWITTE B, DEWULF J, DEMEESTERE K, DE VYVEREN V V, DE WISPELAERE P, VAN LANGENHOVE H. Environ. Sci. Technol., 2008, 42(13):4889-4895.DEWITTE B, DEWULF J, DEMEESTERE K, DE VYVEREN V V, DE WISPELAERE P, VAN LANGENHOVE H. Environ. Sci. Technol., 2008, 42(13):4889-4895.
29. [29]
  ZHOU S Q, SHAO Y S, GAO N Y, ZHU S M, MA Y, DENG J. Ecotoxicol. Environ. Saf., 2014, 107:33-35.ZHOU S Q, SHAO Y S, GAO N Y, ZHU S M, MA Y, DENG J. Ecotoxicol. Environ. Saf., 2014, 107:33-35.
30. [30]
  SHAO K L, YE Z X, HUANGA H, YANG X. Water Res., 2020, 186:116313.SHAO K L, YE Z X, HUANGA H, YANG X. Water Res., 2020, 186:116313.
31. [31]
  JAEN-GIL A, FARRE M J, SÁNCHEZ-MELSIÓ A, SERRA-COMPTE A, BARCELÓ D, RODRÍGUEZ-MOZAZ S. Environ. Sci. Technol., 2020, 54(14):9062-9073.JAEN-GIL A, FARRE M J, SÁNCHEZ-MELSIÓ A, SERRA-COMPTE A, BARCELÓ D, RODRÍGUEZ-MOZAZ S. Environ. Sci. Technol., 2020, 54(14):9062-9073.
32. [32]
  LUIZ D B, GENENA A K, VIRMOND E, JOSE H J, MOREIRA R F P M, GEBHARDT W, SCHRÖDER H F. Water Environ. Res., 2010, 82(9):797-805.LUIZ D B, GENENA A K, VIRMOND E, JOSE H J, MOREIRA R F P M, GEBHARDT W, SCHRÖDER H F. Water Environ. Res., 2010, 82(9):797-805.
33. [33]
  YANG Y J, SHI J C, YANG Y, YIN J, ZHANG J, SHAO B. J. Environ. Sci., 2019, 76:48-56.YANG Y J, SHI J C, YANG Y, YIN J, ZHANG J, SHAO B. J. Environ. Sci., 2019, 76:48-56.
34. [34]
  WANG G Q, SHI W Y, MA D F, GAO B Y. Sci. Total Environ., 2020, 731:138755.WANG G Q, SHI W Y, MA D F, GAO B Y. Sci. Total Environ., 2020, 731:138755.
35. [35]
  MIYASHIRO T, RUBY E G. Mol. Microbiol., 2012, 84(5):795-806.MIYASHIRO T, RUBY E G. Mol. Microbiol., 2012, 84(5):795-806.
36. [36]
  ABBASA M, ADIL M, EHTISHAM-UL-HAQUE S, MUNIR B, YAMMEN M, GHAFFAR A, SHAR G A, TAHIR M A, IQBAL M. Sci. Total Environ., 2018, 626:1295-1309.ABBASA M, ADIL M, EHTISHAM-UL-HAQUE S, MUNIR B, YAMMEN M, GHAFFAR A, SHAR G A, TAHIR M A, IQBAL M. Sci. Total Environ., 2018, 626:1295-1309.
37. [37]
  ZHANG T Q, HE G L, DONG F L, ZHANG Q Z, HUANG Y. Sci. Total Environ., 2019, 676:31-39.ZHANG T Q, HE G L, DONG F L, ZHANG Q Z, HUANG Y. Sci. Total Environ., 2019, 676:31-39.
38. [38]
  MÉDICE R M, AFONSO R G D F, ALMEIDA M L B, DE AQUINO S F, LIBÂNIO M. Environ. Sci. Pollut. Res., 2020, 28(4):3828-3836.MÉDICE R M, AFONSO R G D F, ALMEIDA M L B, DE AQUINO S F, LIBÂNIO M. Environ. Sci. Pollut. Res., 2020, 28(4):3828-3836.
39. [39]
  MOE B, GABOS S, LI X F. Anal. Chim. Acta, 2013, 789:83-90.MOE B, GABOS S, LI X F. Anal. Chim. Acta, 2013, 789:83-90.
40. [40]
  FENG Y X, GUO Q Z, SHAO B. Ecotoxicol. Environ. Saf., 2019, 182:109415.FENG Y X, GUO Q Z, SHAO B. Ecotoxicol. Environ. Saf., 2019, 182:109415.
41. [41]
  ABELLÁN M N, GEBHARDT W, SCHRÖDER H F. Water Sci. Technol., 2008, 58(9):1803-1812.ABELLÁN M N, GEBHARDT W, SCHRÖDER H F. Water Sci. Technol., 2008, 58(9):1803-1812.
42. [42]
  CHEN B Y, ZHANG T, BOND T, GAN Y Q. J. Hazard. Mater., 2015, 299:260-279.CHEN B Y, ZHANG T, BOND T, GAN Y Q. J. Hazard. Mater., 2015, 299:260-279.
43. [43]
  GUO Q Z, DU Z X, SHAO B. J. Hazard. Mater., 2018, 359:31-39.GUO Q Z, DU Z X, SHAO B. J. Hazard. Mater., 2018, 359:31-39.
44. [44]
  FU W J, LI B, YANG J Q, YI H B, CHAI L Y, LI X Y. Chem. Eng. J., 2018, 331:785-793.FU W J, LI B, YANG J Q, YI H B, CHAI L Y, LI X Y. Chem. Eng. J., 2018, 331:785-793.
45. [45]
  LI M, WEI D B, DU Y G. J. Environ. Sci., 2014, 26(9):1837-1842.LI M, WEI D B, DU Y G. J. Environ. Sci., 2014, 26(9):1837-1842.
46. [46]
  HE G L, ZHANG T Q, ZHENG F F, LI C, ZHANG Q Z, DONG F L, HUANG Y. Chem. Eng. J., 2019, 374:1191-1203.HE G L, ZHANG T Q, ZHENG F F, LI C, ZHANG Q Z, DONG F L, HUANG Y. Chem. Eng. J., 2019, 374:1191-1203.
47. [47]
  YIN K, DENG L, LUO J M, CRITTENDEN J, LIU C B, WEI Y F, WANG L L. Chem. Eng. J., 2018, 351:867-877.YIN K, DENG L, LUO J M, CRITTENDEN J, LIU C B, WEI Y F, WANG L L. Chem. Eng. J., 2018, 351:867-877.
48. [48]
  CAI A H, DENG J, XU M Y, ZHU T X, ZHOU S Q, LI J, WANG G F, LI X Y. Chem. Eng. J., 2020, 395:125090.CAI A H, DENG J, XU M Y, ZHU T X, ZHOU S Q, LI J, WANG G F, LI X Y. Chem. Eng. J., 2020, 395:125090.
49. [49]
  DONG H Y, CUTHBERTSON A A, RICHARDSON S D. Environ. Sci. Technol., 2020, 54(3):1290-1292.DONG H Y, CUTHBERTSON A A, RICHARDSON S D. Environ. Sci. Technol., 2020, 54(3):1290-1292.

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沈阳化工大学材料科学与工程学院沈阳 110142

抗生素消毒副产物的分析检测及毒性效应研究进展

通讯作者: 李敏杰,E-mail:mjli@cjlu.edu.cn; 郭良宏,E-mail:lhguo@cjlu.edu.cn

English

Research Progress on Identification and Toxic Effects of Antibiotics Disinfection By-products

Corresponding author: LI Min-Jie, ; GUO Liang-Hong,

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

抗生素消毒副产物的分析检测及毒性效应研究进展

通讯作者: 李敏杰,E-mail:mjli@cjlu.edu.cn; 郭良宏,E-mail:lhguo@cjlu.edu.cn

English

Research Progress on Identification and Toxic Effects of Antibiotics Disinfection By-products

Corresponding author: LI Min-Jie, ; GUO Liang-Hong,

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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