抗生素消毒副产物的分析检测及毒性效应研究进展

蔡东明 欧阳洁 丁锦建 林敏 章维维 李敏杰 郭良宏

引用本文: 蔡东明, 欧阳洁, 丁锦建, 林敏, 章维维, 李敏杰, 郭良宏. 抗生素消毒副产物的分析检测及毒性效应研究进展[J]. 分析化学, 2022, 50(3): 327-340. doi: 10.19756/j.issn.0253-3820.210811 shu
Citation:  CAI Dong-Ming,  OUYANG Jie,  DING Jin-Jian,  LIN Min,  ZHANG Wei-Wei,  LI Min-Jie,  GUO Liang-Hong. Research Progress on Identification and Toxic Effects of Antibiotics Disinfection By-products[J]. Chinese Journal of Analytical Chemistry, 2022, 50(3): 327-340. doi: 10.19756/j.issn.0253-3820.210811 shu

抗生素消毒副产物的分析检测及毒性效应研究进展

    通讯作者: 李敏杰,E-mail:mjli@cjlu.edu.cn; 郭良宏,E-mail:lhguo@cjlu.edu.cn
  • 基金项目:

    国家自然科学基金项目(Nos.U20A20133,21878302)和中国科学院生态环境研究中心中国科学院环境生物技术重点实验室开放课题项目(No.kf2020007)资助。

摘要: 由于抗生素的大量使用和持续排放,其环境污染水平逐年升高,个别抗生素在地表水中浓度接近300 ng/L,在饮用水原水中浓度超过200 ng/L。在饮用水消毒过程中,抗生素会与消毒剂反应生成不同种类的消毒副产物(DBPs),其中一些副产物具有较高的致癌性和急性毒性。饮用水中的抗生素DBPs可危害人体健康,是环境健康科学研究的重要方向之一。本文基于近年文献报道,针对5类常见抗生素(氯霉素类、磺胺类、氟喹诺酮类、四环素类和大环内酯类)的DBPs,首先总结归纳了包括样品前处理、色谱分离和光谱、质谱检测的DBPs分析鉴定方法;然后,按照抗生素类别,概述了特定消毒条件下检测发现的DBPs种类;最后,介绍了包括发光菌抑制法的常见毒性测试方法,以及一些DBPs的毒性评估结果。目前已经发现的抗生素DBPs种类多、数量大,其中一些副产物的毒性显著高于前驱体,有必要开展深入研究。

English


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  • 收稿日期:  2021-10-25
  • 修回日期:  2021-12-31
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