拉曼光谱在感染性疾病诊断中的应用进展

引用本文: 李岩, 祁昱, 李赫. 拉曼光谱在感染性疾病诊断中的应用进展[J]. 分析化学, 2022, 50(3): 317-326. doi: 10.19756/j.issn.0253-3820.210810 shu

Citation: LI Yan, QI Yu, LI He. Advances of Raman Spectroscopy in Diagnosis of Infectious Diseases[J]. Chinese Journal of Analytical Chemistry, 2022, 50(3): 317-326. doi: 10.19756/j.issn.0253-3820.210810 shu

拉曼光谱在感染性疾病诊断中的应用进展

李岩 ^1, ,
祁昱 ^1, ,
李赫 ^{2,
,}

¹大连医科大学附属第一医院检验科, 大连 116011;
²中国科学院宁波材料技术与工程研究所, 中科院海洋新材料与应用技术重点实验室, 宁波 315201

通讯作者: 李赫,E-mail:lihe@nimte.ac.cn

基金项目:
国家自然科学基金项目（No.21675165）资助。

摘要: 感染性疾病危害人类健康，以及全球公共卫生安全。引起感染性疾病的病原微生物种类非常复杂，已有的检测技术通常检测时间长且检出率低，因此临床上急需可用于快速诊断感染性疾病的检测技术。拉曼光谱（Raman spectroscopy）技术为无标记非侵入式检测，无需复杂的前处理，具有无损伤、检测时间短等优点，在感染性疾病快速诊断中表现出巨大应用潜力。本研究对近年来拉曼光谱技术在细菌、病毒、真菌、支原体、衣原体、螺旋体及立克次氏体感染等感染性疾病临床快速诊断中的研究和应用进展进行了总结和评述。

关键词:

English

Advances of Raman Spectroscopy in Diagnosis of Infectious Diseases

LI Yan ^1, ,
QI Yu ^1, ,
LI He ^{2,
,}

¹Department of Clinical Laboratory, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, China;
²Key Laboratory of Marine New Materials and Related Technology, CAS, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China

Corresponding author: LI He, lihe@nimte.ac.cn

Received Date: 25 October 2021
Revised Date: 13 December 2021
Fund Project:
Supported by the National Natural Science Foundation of China (No.21675165).

Abstract: It is not optimistic about the current situation of global infectious diseases. The diseases are harmful not only to human health, but also to the global public health security. The types of pathogenic microorganisms causing infectious diseases are very complex, and the existing detection technologies cannot effectively give the detection result in a short time and the detection rate is not satisfied. Therefore, it is required to develop a rapid detection technology for infectious diseases. Raman spectroscopy shows great potential in the rapid diagnosis of infectious diseases because it is a non-marker and non-invasive detection technique, without complicated sample pretreatment, and can give the detection result in a short time. This article reviewed the advances of Raman spectroscopy in the rapid diagnosis of bacteria, viruses, fungi, mycoplasma, chlamydia, spirochetes and rickettsia infections.

Key words:

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1.
沈阳化工大学材料科学与工程学院沈阳 110142

拉曼光谱在感染性疾病诊断中的应用进展

通讯作者: 李赫,E-mail:lihe@nimte.ac.cn

English

Advances of Raman Spectroscopy in Diagnosis of Infectious Diseases

Corresponding author: LI He, lihe@nimte.ac.cn

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

拉曼光谱在感染性疾病诊断中的应用进展

通讯作者: 李赫,E-mail:lihe@nimte.ac.cn

English

Advances of Raman Spectroscopy in Diagnosis of Infectious Diseases

Corresponding author: LI He, lihe@nimte.ac.cn

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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