聚腺嘌呤保护的金纳米团簇与金属有机框架材料ZIF-8复合物的聚集诱导发光增强及用于抗坏血酸的高灵敏荧光检测

引用本文: 曹程程, 林祥芳, 任晨宇, 苏磊. 聚腺嘌呤保护的金纳米团簇与金属有机框架材料ZIF-8复合物的聚集诱导发光增强及用于抗坏血酸的高灵敏荧光检测[J]. 分析化学, 2022, 50(6): 932-939. doi: 10.19756/j.issn.0253-3820.210807 shu

Citation: CAO Cheng-Cheng, LIN Xiang-Fang, REN Chen-Yu, SU Lei. Polyadenine-capped Gold Nanoclusters Incorporated into Zeolitic Imidazolate Framework-8 with Aggregation-induced Fluorescence Emission Enhancement for High-Sensitivity Fluorescence Detection of Ascorbic Acid[J]. Chinese Journal of Analytical Chemistry, 2022, 50(6): 932-939. doi: 10.19756/j.issn.0253-3820.210807 shu

聚腺嘌呤保护的金纳米团簇与金属有机框架材料ZIF-8复合物的聚集诱导发光增强及用于抗坏血酸的高灵敏荧光检测

北京科技大学化学与生物工程学院, 北京 100083

通讯作者: 苏磊,E-mail:sulei@szu.edu.cn

摘要: 纳米金属有机框架材料（NMOFs）在生物诊断和治疗领域中具有良好的应用前景。本研究建立了一种基于聚腺嘌呤保护的金纳米团簇（PolyA-AuNC）和金属有机框架沸石咪唑酯骨架-8（ZIF-8）纳米复合材料的荧光分析方法，用于血清中抗坏血酸（AA）的高灵敏检测。所制备的纳米复合材料（Poly A-Au NCs@ZIF-8）通过MOF （即ZIF-8）的限制效应显示出聚集诱导的荧光发射增强现象。当AA与ZIF-8作用时，复合材料的骨架被破坏，PolyA-AuNCs从聚集态转变为分散态，导致荧光强度大大降低。将本方法用于AA的检测，线性范围为10~100μmol/L，检出限（LOD，^S/N=3）为0.3μmol/L。本方法可在2 min内完成AA的检测，对AA的选择性高。将本方法用于检测人血清中的AA，回收率为95.7%~100.9%。

关键词:

English

Polyadenine-capped Gold Nanoclusters Incorporated into Zeolitic Imidazolate Framework-8 with Aggregation-induced Fluorescence Emission Enhancement for High-Sensitivity Fluorescence Detection of Ascorbic Acid

School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing 100083, China

Corresponding author: SU Lei, sulei@szu.edu.cn

Received Date: 24 October 2021
Revised Date: 30 March 2022

Abstract: Nano metal organic frameworks(NMOFs) have been widely used in biological diagnosis and treatment systems. In this work, a fluorescence analysis method based on gold nanoclusters(AuNCs) and metal organic framework zeolitic imidazolate framework-8(ZIF-8) composite materials was established for high-sensitivity detection of ascorbic acid(AA). The obtained nanocomposite material(AuNCs@ZIF-8) through the confinement effect of MOF(ZIF-8) showed aggregation-induced emission(AIE) enhancement.When AA was combined with ZIF-8, the framework of the composite material was destroyed, and the fluorescence intensity was greatly reduced due to the transition of AuNCs from the aggregate state to the dispersed state. The linear range of AA detection was measured to be 10-100 μmol/L, and the limit of detection(LOD, S/N=3) was 0.3 μmol/L This method could complete the detection of AA within 2 minutes,showing high selectivity for AA detection. This method was used to detect AA in human serum with good results, and the recoveries were 95.7%-100.9%.

Key words:

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1.
沈阳化工大学材料科学与工程学院沈阳 110142

聚腺嘌呤保护的金纳米团簇与金属有机框架材料ZIF-8复合物的聚集诱导发光增强及用于抗坏血酸的高灵敏荧光检测

通讯作者: 苏磊,E-mail:sulei@szu.edu.cn

English

Polyadenine-capped Gold Nanoclusters Incorporated into Zeolitic Imidazolate Framework-8 with Aggregation-induced Fluorescence Emission Enhancement for High-Sensitivity Fluorescence Detection of Ascorbic Acid

Corresponding author: SU Lei, sulei@szu.edu.cn

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

聚腺嘌呤保护的金纳米团簇与金属有机框架材料ZIF-8复合物的聚集诱导发光增强及用于抗坏血酸的高灵敏荧光检测

通讯作者: 苏磊,E-mail:sulei@szu.edu.cn

English

Polyadenine-capped Gold Nanoclusters Incorporated into Zeolitic Imidazolate Framework-8 with Aggregation-induced Fluorescence Emission Enhancement for High-Sensitivity Fluorescence Detection of Ascorbic Acid

Corresponding author: SU Lei, sulei@szu.edu.cn

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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通讯作者: 陈斌, bchen63@163.com

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