Citation: CANG Huai-Wen, LI Hang, HUANG Wei, ZHANG Yuan-Zhi, LI Jing-Hua, WANG Wei-Guo, LI Hai-Yang. Improving Performance of Ion Mobility Spectrometry Using Bradbury-Nielsen Ion Gate Pulse Waveform Modulation[J]. Chinese Journal of Analytical Chemistry, ;2021, 49(12): 2067-2074. doi: 10.19756/j.issn.0253-3820.210684 shu

Improving Performance of Ion Mobility Spectrometry Using Bradbury-Nielsen Ion Gate Pulse Waveform Modulation

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Key Laboratory for Online Analytical Instrumentation, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China

Corresponding author: WANG Wei-Guo, LI Hai-Yang,
Received Date: 17 August 2021
Revised Date: 30 September 2021

Fund Project: Supported by the National Natural Science Foundation of China (Nos. 22027804, 91961124) and the Foundation of Dalian Institute of Chemical Physics, Chinese Academy of Sciences (Nos. DICPI201951, DICP ZZBS201701).

Ion mobility spectrometry (IMS) has been widely used in the field of detecting explosives, chemical agents and environmental pollutants due to the advantages such as high sensitivity, fast response ability and portability. How to improve the sensitivity and resolution of IMS has always been a research hot spot. The sensitivity and resolution are closely related to the characteristics of the initial ion current that is controlled by the voltage waveform applied to the ion gate. In this work, the voltage waveforms of different Bradbury-Nielsen (BN) ion gates were simulated by SIMION software. It was found that the performances of IMS including the sensitivity and resolution could be improved by adjusting the voltage waveform. The homemade research platform of IMS was built, and the effects of switching pulse waveform time (Δt₁), pulse voltage width (GPW) and pulse voltage difference (GVD) on the signal intensity and resolution of IMS were systematically investigated. The results showed that when GPW=80 μs, the acetone ion RIP intensity was increased by 3 times and the resolution was increased by 13%. When detecting dimethyl methylphosphate (DMMP) sample (5.8 μg/L), the ion intensities of (Ac)₂H⁺, (Ac)(DMMP) H⁺ and (DMMP)₂H⁺ were increased by 81%, 156% and 260%, respectively. Meanwhile, the signal-to-noise ratio of (Ac)(DMMP) H⁺ was increased by 2.5 times and that of (DMMP)₂H⁺ was increased by 3 times. The results were helpful to develop high resolution ion mobility spectrometer.
- Drift time ion mobility spectrometry,
- Switching pulse square wave,
- Bradbury-Nielsen gate
1. [1]
  PUTON J, NAMIESNIK J. TrAC-Trends Anal. Chem., 2016, 85:10-20.
2. [2]
  SETO Y, HASHIMOTO R, TANIGUCHI T, OHRUI Y, NAGOYA T, IWAMATSU T, KOMARU S, USUI D, MORIMOTO S, SAKAMOTO Y, ISHIZAKI A, NISHIDE T, INOUE Y, SUGIYAMA H, NAKANO N. Anal. Chem., 2019, 91(8):5403-5414.
3. [3]
  EHLERT S, WALTE A, ZIMMERMANN R. Anal. Chem., 2013, 85(22):11047-11053.
4. [4]
  MIDEY A J, PATEL A, MORAFF C, KRUEGER C A, WU C. Talanta, 2013, 116:77-83.
5. [5]
  VAUTZ W, HARIHARAN C, WEIGEND M. Ecol. Evol., 2018, 8(9):4370-4377.
6. [6]
  GALLART-MATEU D, ARMENTA S, DE LA GUARDIA M. Talanta, 2016, 161:632-639.
7. [7]
8. [8]
  JIANG D D, LI EY, ZHOU Q H, WANG X, LI H W, JU B Y, GUO L, LIU D S, LI H Y. Anal. Chem., 2018, 90(8):5280-5289.
9. [9]
  JIANG D D, CHEN C, WANG W M, WANG W G, LI M, WANG X, LIU Y P, LI E Y, LI H Y. Anal. Chem. Acta, 2021, 1150:338223.
10. [10]
  TARVER E E. Sensors, 2004, 4(1-3):1-13.
11. [11]
  CLOWERS B H, SIEMS W F, HILL H H, MASSICK S M. Anal. Chem., 2006, 78(1):44-51.
12. [12]
  DU Y Z, CANG H W, WANG W G, HAN F L, CHEN C, LI H Y. Rev. Sci. Instrum., 2011, 82(8):086103.
13. [13]
  SALLERAS M, KALMS A, KRENKOW A, KESSLER M, GOEBEL J, MULLER G, MARCO S. Sens. Actuators, B, 2006, 118(1-2):338-342.
14. [14]
  KIRK A T, ZIMMERMANN S. Int. J. Ion Mobil. Spectroom., 2014, 17(3-4):131-137.
15. [15]
  CHEN H, CHEN C, LI M, WANG W G, JIANG D D, LI H Y. Anal. Chim. Acta, 2019, 1052:96-104.
16. [16]
  CHEN C, CHEN H, JIANG D D, LI M, HUANG W, LI H Y. Sens. Actuators, B, 2019, 295:179-185.
17. [17]
  KIRK A T, ALLERS M, COCHEMS P, LANGEJUERGEN J, ZIMMERMANN S. Analyst, 2013, 138(18):5200-5207.
18. [18]
  KIRK A T, KUEDDELSMANN M J, BOHNHORST A, LIPPMANN M, ZIMMERMANN S. Anal. Chem., 2020, 92(7):4838-4847.
19. [19]
  PUTON J, KNAP A, SIODLOWSKI B. Sens. Actuators, B, 2008, 135(1):116-121.
20. [20]
  TADJIMUKHAMEDOV F K, PUTON J, STONE J A, EICEMAN G A. Rev. Sci. Instrum., 2009, 80(10):103103.
21. [21]
  DU Y Z, WANG W G, LI H Y. Anal. Chem., 2012, 84(3):1725-1731.
22. [22]
  DU Y Z, WANG W G, LI H Y. Anal. Chem., 2012, 84(13):5700-5707.
23. [23]
  CHEN C, CHEN H, LI H Y. Anal. Chem., 2017, 89(24):13398-13404.
24. [24]
  CHEN H, CHEN C, HUANG W, LI M, XIAO Y, JIANG D D, LI H Y. Anal. Chem., 2019, 91(14):9138-9146.
25. [25]
  CHEN C, TABRIZCHI M, WANG W G, LI H Y. Anal. Chem., 2015, 87(15):7925-7930.
26. [26]
  ZVHLKE M, ZENICHOWSKI K, RIEBE D, BEITZ T, LÖHMANNSRÖBEN H G. Int. J. Ion Mobil Spectrom., 2017, 20(3-4):67-73.
27. [27]
  REINECKE T, KIRK A T, AHRENS A, RADDATZ C R, THOBEN C, ZIMMERMANN S. Talanta, 2016,150(1):1-6.
28. [28]
  LANGEJUERGEN J, ALLERS M, OERMANN J, KIRK A, ZIMMERMANN S. Anal. Chem., 2014, 86(14):7023-7032.
29. [29]
  KIRK A T, GRUBE D, KOBELT T, WENDT C, ZIMMERMANN S. Anal. Chem., 2018, 90(9):5603-5611.
1. [1]
  Shuang Wang , Xiaoqi Fu , Shanshan Yao . Synergistic optimization of ion migration and electron transfer in sodium-ion battery cathode materials. Acta Physico-Chimica Sinica, 2026, 42(5): 100206-0. doi: 10.1016/j.actphy.2025.100206
2. [2]
  Zhenjun Mao , Haorui Gu , Haiyan Che , Xufeng Lin . Exploration on Experiment Teaching of UHPLC-IC Based on Valve Switching Method. University Chemistry, 2024, 39(4): 81-86. doi: 10.3866/PKU.DXHX202311013
3. [3]
  Dongqi Cai , Fuping Tian , Zerui Zhao , Yanjuan Zhang , Yue Dai , Feifei Huang , Yu Wang . Exploration of Factors Influencing the Determination of Ion Migration Number by Hittorf Method. University Chemistry, 2024, 39(4): 94-99. doi: 10.3866/PKU.DXHX202310031
4. [4]
  Jiayu Tang , Jichuan Pang , Shaohua Xiao , Xinhua Xu , Meifen Wu . Improvement for Measuring Transference Numbers of Ions by Moving-Boundary Method. University Chemistry, 2024, 39(5): 193-200. doi: 10.3866/PKU.DXHX202311021
5. [5]
  Rui Li , Huan Liu , Yinan Jiao , Shengjian Qin , Jie Meng , Jiayu Song , Rongrong Yan , Hang Su , Hengbin Chen , Zixuan Shang , Jinjin Zhao . Emerging Irreversible and Reversible Ion Migrations in Perovskites. Acta Physico-Chimica Sinica, 2024, 40(11): 2311011-0. doi: 10.3866/PKU.WHXB202311011
6. [6]
  Shanghua Li , Malin Li , Xiwen Chi , Xin Yin , Zhaodi Luo , Jihong Yu . High-Stable Aqueous Zinc Metal Anodes Enabled by an Oriented ZnQ Zeolite Protective Layer with Facile Ion Migration Kinetics. Acta Physico-Chimica Sinica, 2025, 41(1): 100003-0. doi: 10.3866/PKU.WHXB202309003
7. [7]
  Zilin Hu , Yaoshen Niu , Xiaohui Rong , Yongsheng Hu . Suppression of Voltage Decay through Ni³⁺ Barrier in Anionic-Redox Active Cathode for Na-Ion Batteries. Acta Physico-Chimica Sinica, 2024, 40(6): 2306005-0. doi: 10.3866/PKU.WHXB202306005
8. [8]
  Peicai Li , Xubin Wang , Qinghua Zhang , Bowen Wang , Xiaohui Rong , Yong-Sheng Hu , Zhongtao Li . High-rate and long-cycling P2-type cathode material for sodium-ion batteries. Acta Physico-Chimica Sinica, 2026, 42(5): 100214-0. doi: 10.1016/j.actphy.2025.100214
9. [9]
  Aoyu Huang , Jun Xu , Yu Huang , Gui Chu , Mao Wang , Lili Wang , Yongqi Sun , Zhen Jiang , Xiaobo Zhu . Tailoring Electrode-Electrolyte Interfaces via a Simple Slurry Additive for Stable High-Voltage Lithium-Ion Batteries. Acta Physico-Chimica Sinica, 2025, 41(4): 100037-0. doi: 10.3866/PKU.WHXB202408007
10. [10]
  Zhiming Feng , Lili Wu , Chengming Wang . Doubly Oxidized Carbene. University Chemistry, 2025, 40(9): 326-331. doi: 10.12461/PKU.DXHX202411008
11. [11]
  Jianbao Mei , Bei Li , Shu Zhang , Dongdong Xiao , Pu Hu , Geng Zhang . Enhanced Performance of Ternary NASICON-Type Na_3.5−xMn_0.5V_1.5−xZr_x (PO₄)₃/C Cathodes for Sodium-Ion Batteries. Acta Physico-Chimica Sinica, 2024, 40(12): 2407023-0. doi: 10.3866/PKU.WHXB202407023
12. [12]
  Rongrong Wang , Chen Li , Xiang Ren , Keliang Zhang , Yu Sun , Xianzhong Sun , Kai Wang , Xiong Zhang , Yanwei Ma . Recent advances and challenges of eco-friendly Ni-rich cathode slurry systems in lithium-ion batteries. Acta Physico-Chimica Sinica, 2026, 42(4): 100222-0. doi: 10.1016/j.actphy.2025.100222
13. [13]
  Yuyao Wang , Zhitao Cao , Zeyu Du , Xinxin Cao , Shuquan Liang . Research Progress of Iron-based Polyanionic Cathode Materials for Sodium-Ion Batteries. Acta Physico-Chimica Sinica, 2025, 41(4): 100035-0. doi: 10.3866/PKU.WHXB202406014
14. [14]
  Tieping CAO , Yuejun LI , Dawei SUN . Surface plasmon resonance effect enhanced photocatalytic CO₂ reduction performance of S-scheme Bi₂S₃/TiO₂ heterojunction. Chinese Journal of Inorganic Chemistry, 2025, 41(5): 903-912. doi: 10.11862/CJIC.20240366
15. [15]
  Kexin Dong , Chuqi Shen , Ruyu Yan , Yanping Liu , Chunqiang Zhuang , Shijie Li . Integration of Plasmonic Effect and S-Scheme Heterojunction into Ag/Ag₃PO₄/C₃N₅ Photocatalyst for Boosted Photocatalytic Levofloxacin Degradation. Acta Physico-Chimica Sinica, 2024, 40(10): 2310013-0. doi: 10.3866/PKU.WHXB202310013
16. [16]
  Ronghao Zhao , Yifan Liang , Mengyao Shi , Rongxiu Zhu , Dongju Zhang . Investigation into the Mechanism and Migratory Aptitude of Typical Pinacol Rearrangement Reactions: A Research-Oriented Computational Chemistry Experiment. University Chemistry, 2024, 39(4): 305-313. doi: 10.3866/PKU.DXHX202309101
17. [17]
  Wenjun Zheng . Application in Inorganic Synthesis of Ionic Liquids. University Chemistry, 2024, 39(8): 163-168. doi: 10.3866/PKU.DXHX202401020
18. [18]
  Guoze Yan , Bin Zuo , Shaoqing Liu , Tao Wang , Ruoyu Wang , Jinyang Bao , Zhongzhou Zhao , Feifei Chu , Zhengtong Li , Yamauchi Yusuke , Melhi Saad , Xingtao Xu . Opportunities and Challenges of Capacitive Deionization for Uranium Extraction from Seawater. Acta Physico-Chimica Sinica, 2025, 41(4): 100032-0. doi: 10.3866/PKU.WHXB202404006
19. [19]
  Jing Tan , Bo Zheng , Lingyan Gao . Application of Crown Ether-Based Artificial Ion Transporters. University Chemistry, 2026, 41(2): 232-237. doi: 10.12461/PKU.DXHX202501010
20. [20]
  Hong LI , Xiaoying DING , Cihang LIU , Jinghan ZHANG , Yanying RAO . Detection of iron and copper ions based on gold nanorod etching colorimetry. Chinese Journal of Inorganic Chemistry, 2024, 40(5): 953-962. doi: 10.11862/CJIC.20230370

Get Citation

PDF

XML

Metrics

PDF Downloads(9)
Abstract views(1149)
HTML views(160)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142