Citation: ZHAO Ya-Jie, XIAO Xiao, MA Ping-An, LIN Jun. Application of Hollow Manganese Carbonate Nanocarriers in Chemodynamic/Sonodynamic Tumor Therapy[J]. Chinese Journal of Analytical Chemistry, ;2021, 49(12): 2015-2022. doi: 10.19756/j.issn.0253-3820.210626 shu

Application of Hollow Manganese Carbonate Nanocarriers in Chemodynamic/Sonodynamic Tumor Therapy

ZHAO Ya-Jie ^1,2 ,
XIAO Xiao ^1,2 ,
MA Ping-An ^1,2,, ,
LIN Jun ^1,2,,

1.
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China;
2.
University of Science and Technology of China, Hefei 230026, China

Corresponding author: MA Ping-An, LIN Jun,
Received Date: 12 July 2021
Revised Date: 28 September 2021

Fund Project: Supported by the National Natural Science Foundation of China (Nos.51720105015, 51672269, 51929201, 51922097, 51772124, 51872282), the Science and Technology Cooperation Project between Chinese and Australian Governments (No.2017YFE0132300).

It is an effective attempt to increase the level of reactive oxygen species (ROS) to abrogate the redox balance and successively result in sever cells oxidative damage and death in cancer treatment. Herein, biodegradable, safe and tumor-specific hollow manganese carbonate (MnCO₃) nanocarriers (HMC NPs) were synthesized by hydrothermal method. HMC NPs loaded with sonosensitizer protoporphyrin (PpIX) constituted HMC-PpIX nanoparticles (HMC-P NPs), which could be activated in the acidic tumor microenvironment (TME). By degrading and releasing Mn²⁺ and sonosensitizer, the overloaded Mn²⁺ in the tumor triggered the Fenton reaction under the physiological buffer environment of HCO₃^-/CO₂, which converted the over-expressed endogenous hydrogen peroxide (H₂O₂) to highly toxic hydroxyl radicals (·OH). Moreover, under the irradiation of ultrasound, PpIX could convert oxygen in cells to singlet oxygen (¹O₂), forming continuous and accumulated oxygen stress. The synergistic treatment of chemodynamic therapy (CDT) and sonodynamic therapy (SDT) could produce a large amount of reactive oxygen species in tumor cells, which broke the self-regulation ability of malignant tumor cells, and caused oxidative damage to multiple intracellular organelles, and ultimately led to the death of cancer cells. In addition, under the adjuvant treatment of anticancer drugs doxorubicin (DOX) and ultrasound irradiation, the killing efficiency of cancer cell was about 90%. And the experimental group also achieved good tumor inhibition effects in vivo.
- Hollow manganese carbonate,
- Ttumor microenvironment-responsive,
- Chemodynamic therapy,
- Sonodynamic therapy,
- Synergistic therapy
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