Citation: XIE Chen-Xia, ZENG Chao, ZHUANG Qian-Fen, WANG Yong. Adenosine-stabilized Copper Nanocluster as Fluorescent Probe for Detection of Au(Ⅲ) Ion and Cysteine[J]. Chinese Journal of Analytical Chemistry, ;2021, 49(11): 1824-1833. doi: 10.19756/j.issn.0253-3820.210619 shu

Adenosine-stabilized Copper Nanocluster as Fluorescent Probe for Detection of Au(Ⅲ) Ion and Cysteine

1.
College of Chemistry, Nanchang University, Nanchang 330031, China;
2.
Jiangxi Province Key Laboratory of Modern Analytical Science, Nanchang University, Nanchang 330031, China

Corresponding author: ZHUANG Qian-Fen, qfzhuang@ncu.edu.cn
Received Date: 9 July 2021
Revised Date: 26 August 2021

Fund Project: Supported by the National Natural Science Foundation of China (Nos.31960495, 32160600, 21864017), the Science and Technology Innovation Platform Project of Jiangxi Province, China (No.20192BCD40001), the Open Project Program of State Key Laboratory of Food Science and Technology, Nanchang University (No.SKLF-KF-201810), and the State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University (No.SKLCBC-2018007).

A fluorescent "turn-off-on" sensor was constructed for detection of Au(Ⅲ) ions and cysteine on the basis of fluorescence quenching of adenosine-stabilized copper nanocluster by Au(Ⅲ) ions and cysteine-induced fluorescence enhancement of the adenosine-stabilized copper nanocluster/Au(Ⅲ) system. The adenosine-stabilized copper nanocluster-based sensor gave a linear range of 0.05-10 μmol/L with detection limit of 0.02 μmol/L, and the adenosine-stabilized copper nanocluster/Au(Ⅲ)-based sensor provided a linear range of 5-60 μmol/L with detection limit of 1.6 μmol/L. In addition, the results showed that the fluorescence quenching of adenosine-stabilized copper nanocluster by Au(Ⅲ) ion was mainly originated from the super amplification static quenching effect, and the fluorescence enhancement of the adenosine-stabilized copper nanocluster/Au(Ⅲ) by cysteine mainly arose from the complex reaction between cysteine and Au(Ⅲ) and the removal of Au(Ⅲ) on the adenosine-stabilized copper nanocluster/Au(Ⅲ) system. Additionally, the fluorescence sensor for Au(Ⅲ) ions and cysteine possessed high selectivity, and could be successfully used for detection of Au(Ⅲ) ions in water samples and cysteine in pharmaceutical preparations.
- Fluorescent copper nanocluster,
- Au(Ⅲ) ion,
- Cysteine,
- Sensor
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沈阳化工大学材料科学与工程学院沈阳 110142