Citation: ZHAO Hui-Fang, ZHAO Hua-Yu, YI Si-Wen, ZHANG Rui-Ping. Nickel Nanoparticles/Graphene Composite as New Matrix-assisted Laser Desorption/Ionization Matrix and Adsorbent for Highly Efficient Mass Spectrometry Analysis of Small Biomolecules[J]. Chinese Journal of Analytical Chemistry, ;2021, 49(12): 2055-2066. doi: 10.19756/j.issn.0253-3820.210604 shu

Nickel Nanoparticles/Graphene Composite as New Matrix-assisted Laser Desorption/Ionization Matrix and Adsorbent for Highly Efficient Mass Spectrometry Analysis of Small Biomolecules

1.
School of Basic Medical Sciences, Shanxi Medical University, Taiyuan 030001, China;
2.
Shanxi Bethune Hospital, the Third Hospital of Shanxi Medical University, Taiyuan 030032, China

Corresponding author: ZHANG Rui-Ping, zrp_7142@sxmu.edu.cn
Received Date: 2 July 2021
Revised Date: 24 September 2021

Fund Project: Supported by the National Natural Science Foundation of China (Nos.22004082, 81771907) and the Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi Province, China (No.2020L0173).

The nickel nanoparticles/graphene (Ni/Gr) composite synthesized here was served as a novel matrix and adsorbent for highly efficient matrix-assisted laser desorption/ionization time-of-flight mass spectroscopy (MALDI-TOF MS) analysis of various pharmaceutical molecules and amino acids. In comparison with 2,5-dihydroxybenzoic acid (DHB) and the control substances (Gr, Ni-1/Gr, Ni-5/Gr), the Ni-2/Gr matrix exhibited excellent performances in detection of resveratrol, 6-gingerol and rutin under positive-ion mode, including low background noise, high ion intensity, high signal to noise ratio and wide linear range (0.01-50 μmol/L, 0.2-50 μmol/L and 0.05-60 μmol/L). Meanwhile, the low limit of detection (LODs) of resveratrol, 6-gingerol and rutin were 0.0038 μmol/L, 0.09 μmol/L and 0.02 μmol/L, respectively. Benefiting from high surface area, abundant mesoporous structures, lots of sp² structure, strong UV absorption and high saturation magnetization (Ms) value, Ni-2/Gr composite also acted as a favorable adsorbent for effectively analysis of L-phenylalanine, L-tryptophan and L-tyrosine with magnetic enrichment. Further, the low concentration of L-tryptophan spiked in mice serum bio-samples was directly enriched.
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