银-金双金属纳米管的可控制备及其对汗液中葡萄糖的无创检测

引用本文: 高难, 王帅澎, 刘旭, 夏大成, 蔡志伟, 常钢, 何云斌. 银-金双金属纳米管的可控制备及其对汗液中葡萄糖的无创检测[J]. 分析化学, 2021, 49(10): 1640-1648. doi: 10.19756/j.issn.0253-3820.210601 shu

Citation: GAO Nan, WANG Shuai-Peng, LIU Xu, XIA Da-Cheng, CAI Zhi-Wei, CHANG Gang, HE Yun-Bin. Controllable Preparation of Ag-Au Bimetallic Nanotubes for Non-invasive Detection of Glucose in Sweat[J]. Chinese Journal of Analytical Chemistry, 2021, 49(10): 1640-1648. doi: 10.19756/j.issn.0253-3820.210601 shu

银-金双金属纳米管的可控制备及其对汗液中葡萄糖的无创检测

湖北大学材料科学与工程学院, 功能材料绿色制备与应用教育部重点实验室, 高分子材料湖北省重点实验室, 武汉 430062

通讯作者: 常钢,E-mail:changgang@hubu.edu.cn; 何云斌,E-mail:ybhe@hubu.edu.cn

基金项目:
国家自然科学基金项目（Nos.51672074，11774082，11975093）、湖北省自然科学基金项目（No.2019CFA006）和武汉市应用基金前沿项目（No.201801041011287）资助。

摘要: 实时监测血糖水平对糖尿病患者的诊断和治疗具有重要意义，而传统的酶法微创测定存在稳定性低、体验感差等问题。本研究以银纳米线为模板，采用一步伽伐尼置换反应（Galvanic replacement reaction）制备高质量的银-金双金属纳米管（Ag-Au BMNTs），实现了对葡萄糖的无酶、无创测定。通过优化HAuCl₄的含量，可调控Ag-Au BMNTs的形貌及组分。研究结果表明，Ag-Au BMNTs检测葡萄糖具有检测范围宽（1 μmol/L~3.79 mmol/L，3.79~13.79 mmol/L）、灵敏度高（154.09 μA/（mmol/L）、60.77 μA/（mmol/L）和检出限低（1 μmol/L）等特点。同时，此传感器表现出良好的抗干扰性能和稳定性，可用于人体汗液中葡萄糖含量的准确测定。基于Ag-Au BMNTs的电化学传感器在无酶、无创血糖检测中具有良好的潜在应用价值。

关键词:

English

Controllable Preparation of Ag-Au Bimetallic Nanotubes for Non-invasive Detection of Glucose in Sweat

Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei Key Laboratory of Polymer Materials, School of Materials Science and Engineering, Hubei University, Wuhan 430062, China

Corresponding author: CHANG Gang, ; HE Yun-Bin,

Received Date: 01 July 2021
Revised Date: 03 August 2021
Fund Project:
Supported by the National Natural Science Foundation of China (Nos.51672074, 11774082, 11975093), the Natural Science Foundation of Hubei Province, China (No.2019CFA006) and the Wuhan Application Foundation Frontier Project (No.201801041011287).

Abstract: Real-time monitoring of blood glucose levels is of great significance for the diagnosis and treatment of diabetic patients. However, traditional enzymatic minimally invasive determinations have problems such as low stability and poor experience. By using silver nanowires as a template, high-quality Ag-Au bimetallic nanotubes (Ag-Au BMNTs/GCE) could be successfully prepared by a one-step Galvanic replacement reaction to realize the non-enzymatic and non-invasive measurement of glucose. By optimizing the content of HAuCl₄, the morphology and composition of Ag-Au bimetallic nanotubes could be controlled. The research results showed that the Ag-Au BMNTs/GCE had a wide detection range for glucose detection (1 μmol/L-3.79 mmol/L, 3.79 mmol/L-13.79 mmol/L), high sensitivity (154.09 μA/(mmol/L), 60.77 μA/(mmol/L)) and low detection limit (1 μmol/L). At the same time, the sensor showed good anti-interference performance and stability, and was successfully applied to the accurate determination of glucose content in human sweat, which indicated that the electrochemical sensor based on Ag-Au BMNTs had potential application value in the field of non-enzyme and non-invasive blood glucose detection.

Key words:

1. [1]
  SU S, LU W Z, LIA J, HAO Q, LIU W, ZHU C F, SHEN X Z, SHI.J Y, WANG L H. New J. Chem., 2018, 42:6750-6755.SU S, LU W Z, LIA J, HAO Q, LIU W, ZHU C F, SHEN X Z, SHI.J Y, WANG L H. New J. Chem., 2018, 42:6750-6755.
2. [2]
  XU J, XUK K, HAN Y, WANG D, LI X, HU T, YI H, NI Z H. Analyst, 2020, 145:5141-5147.XU J, XUK K, HAN Y, WANG D, LI X, HU T, YI H, NI Z H. Analyst, 2020, 145:5141-5147.
3. [3]
  SHAO M F, XU X Y, HAN J B, ZHAO J W, SHI W Y, KONG X G, WEI M, EVANS D G, DUAN X. Langmuir, 2011, 27(13):8233-8240.SHAO M F, XU X Y, HAN J B, ZHAO J W, SHI W Y, KONG X G, WEI M, EVANS D G, DUAN X. Langmuir, 2011, 27(13):8233-8240.
4. [4]
  CASH K J, CLARK H A. Trends Mol. Med., 2010, 16(12):584-593.CASH K J, CLARK H A. Trends Mol. Med., 2010, 16(12):584-593.
5. [5]
  TIAN K, PRESTGAID M, TIWARI A. Mater. Sci. Eng., C, 2014, 41:100-118.TIAN K, PRESTGAID M, TIWARI A. Mater. Sci. Eng., C, 2014, 41:100-118.
6. [6]
  LIU J, SHEN X, BAIMANOV D, WANG L, XIAO Y, LIU H, LI Y, GAO X, ZHAO Y, CHEN C. ACS Appl. Mater. Interfaces, 2019, 11(3):2647-2654.LIU J, SHEN X, BAIMANOV D, WANG L, XIAO Y, LIU H, LI Y, GAO X, ZHAO Y, CHEN C. ACS Appl. Mater. Interfaces, 2019, 11(3):2647-2654.
7. [7]
  KIM H S, LEE J S, KIM M I. J.Nanosci. Nanotechnol., 2020, 20(9):5333-5337.KIM H S, LEE J S, KIM M I. J.Nanosci. Nanotechnol., 2020, 20(9):5333-5337.
8. [8]
  JANG H, OH J, KI H, KIM M G. Analyst, 2020, 145(17):5740-5743.JANG H, OH J, KI H, KIM M G. Analyst, 2020, 145(17):5740-5743.
9. [9]
  CHANG G, SHU H H, JI K, ORAMA M, LIU X, HE Y B. Appl. Surf. Sci., 2014, 288:524-529.CHANG G, SHU H H, JI K, ORAMA M, LIU X, HE Y B. Appl. Surf. Sci., 2014, 288:524-529.
10. [10]
  ENSAFI A A, ZANDI-ATASHBAR N, REZAEI B, GHIACI M, CHERMAHINI M E, MOSHIRI P. RSC Adv., 2016, 6(65):60926-60932.ENSAFI A A, ZANDI-ATASHBAR N, REZAEI B, GHIACI M, CHERMAHINI M E, MOSHIRI P. RSC Adv., 2016, 6(65):60926-60932.
11. [11]
  SHU H H, CHANG G, SU J, CAO L L, HUANG Q W, ZHANG Y T, XIA T T, HE Y B. Sens. Actuators, B, 2015, 220:331-339.SHU H H, CHANG G, SU J, CAO L L, HUANG Q W, ZHANG Y T, XIA T T, HE Y B. Sens. Actuators, B, 2015, 220:331-339.
12. [12]
  NIU X, LAN M, ZHAO H, CHEN C. Anal. Chem., 2013, 85(7):3561-3569.NIU X, LAN M, ZHAO H, CHEN C. Anal. Chem., 2013, 85(7):3561-3569.
13. [13]
  JIA H M, CHANG G, LEI M, HE H P, LIU X, SHU H H, XIA T T, SU J, HE Y B. Appl. Surf. Sci., 2016, 384:58-64.JIA H M, CHANG G, LEI M, HE H P, LIU X, SHU H H, XIA T T, SU J, HE Y B. Appl. Surf. Sci., 2016, 384:58-64.
14. [14]
  YE J H, DENG D M, WANG Y Q, LUO L Q, QIAN K P, CAO S M, FENG X. Sens. Actuators, B, 2020, 305:127473.YE J H, DENG D M, WANG Y Q, LUO L Q, QIAN K P, CAO S M, FENG X. Sens. Actuators, B, 2020, 305:127473.
15. [15]
  ZHU T X, WANG X E, CHANG W W, ZHANG Y F, MARUYAMA T, LUO L Q, ZHAO X L. Mater. Sci. Eng., C, 2021, 120:111757.ZHU T X, WANG X E, CHANG W W, ZHANG Y F, MARUYAMA T, LUO L Q, ZHAO X L. Mater. Sci. Eng., C, 2021, 120:111757.
16. [16]
  MOYER J, WILSON D, FINKELSHTEIN I, WONG B, POTTS R. Diabetes Technol. Ther., 2012, 14(5):398-402.MOYER J, WILSON D, FINKELSHTEIN I, WONG B, POTTS R. Diabetes Technol. Ther., 2012, 14(5):398-402.
17. [17]
  LIPANI L, DUPONT B G R, DOUNGMENE F, MARKEN F, TYRRELL R H, GUY R N, ILIE A. Nat. Nanotechnol., 2018, 13(6):504-511.LIPANI L, DUPONT B G R, DOUNGMENE F, MARKEN F, TYRRELL R H, GUY R N, ILIE A. Nat. Nanotechnol., 2018, 13(6):504-511.
18. [18]
  NANTAPHOL S, WATANABE T, NOMURA N, SIANGPROH W, CHAILAPAKUL O, EINAGA Y. Biosens. Bioelectron., 2017, 98:76-82.NANTAPHOL S, WATANABE T, NOMURA N, SIANGPROH W, CHAILAPAKUL O, EINAGA Y. Biosens. Bioelectron., 2017, 98:76-82.
19. [19]
  GARCÍA-MORALES N G, GARCÍA-CERDA L A, PUENTE-URBINA B A, BLANCO-JEREZ L M, ANTAÑO-LÓPEZ R, CASTAÑEDA-ZALDIVAR F. J. Nanomater., 2015, 2015:205314.GARCÍA-MORALES N G, GARCÍA-CERDA L A, PUENTE-URBINA B A, BLANCO-JEREZ L M, ANTAÑO-LÓPEZ R, CASTAÑEDA-ZALDIVAR F. J. Nanomater., 2015, 2015:205314.
20. [20]
  ARVINTE A, CRUDU I A, DOROFTEI F, TIMPU D, PINTEALA M. J. Electroanal. Chem., 2018, 829:184-193.ARVINTE A, CRUDU I A, DOROFTEI F, TIMPU D, PINTEALA M. J. Electroanal. Chem., 2018, 829:184-193.
21. [21]
  CHEN L, LONG K, YU X, LI W, GENG B. Chem. -Eur. J., 2013, 19(35):11753-11758.CHEN L, LONG K, YU X, LI W, GENG B. Chem. -Eur. J., 2013, 19(35):11753-11758.
22. [22]
  HUNYADI S E, MURPHY C J. J. Mater. Chem., 2006, 16(40):3929-3935.HUNYADI S E, MURPHY C J. J. Mater. Chem., 2006, 16(40):3929-3935.
23. [23]
  WU P, GAO Y, ZHANG H, CAI C. Anal. Chem., 2012, 84(18):7692-7699.WU P, GAO Y, ZHANG H, CAI C. Anal. Chem., 2012, 84(18):7692-7699.
24. [24]
  COSTA J C, CORIO P, ROSSI L M. Nanoscale, 2015, 7(18):8536-8543.COSTA J C, CORIO P, ROSSI L M. Nanoscale, 2015, 7(18):8536-8543.
25. [25]
  YANG P H, GAO X, WANG L S, WU Q, CHEN Z C, LIN X F. Microchim. Acta, 2013, 181(1-2):231-238.YANG P H, GAO X, WANG L S, WU Q, CHEN Z C, LIN X F. Microchim. Acta, 2013, 181(1-2):231-238.
26. [26]
  LI B, YE S, STEWART I E, ALVAREZ S, WILEY B J. Nano Lett., 2015, 15(10):6722-6726.LI B, YE S, STEWART I E, ALVAREZ S, WILEY B J. Nano Lett., 2015, 15(10):6722-6726.
27. [27]
  SUN Y G, XIA Y N. J. Am. Chem. Soc., 2004, 126(12):3892-3901.SUN Y G, XIA Y N. J. Am. Chem. Soc., 2004, 126(12):3892-3901.
28. [28]
  DA SILVA R R, YANG M, CHOI S I, CHI M, LUO M, ZHANG C, LI Z Y, CAMARGO P H, RIBEIRO S J, XIA Y N. ACS Nano, 2016, 10(8):7892-7900.DA SILVA R R, YANG M, CHOI S I, CHI M, LUO M, ZHANG C, LI Z Y, CAMARGO P H, RIBEIRO S J, XIA Y N. ACS Nano, 2016, 10(8):7892-7900.
29. [29]
  JACKSON J B, WESTCOTT S L, HIRSCH L R, WEST J L, HALAS N J. Appl. Phys. Lett., 2003, 82(2):257-259.JACKSON J B, WESTCOTT S L, HIRSCH L R, WEST J L, HALAS N J. Appl. Phys. Lett., 2003, 82(2):257-259.
30. [30]
  SHIN K S, KIM J H, KIM I H, KIM K. J. Nanopart. Res., 2012, 14(3):735.SHIN K S, KIM J H, KIM I H, KIM K. J. Nanopart. Res., 2012, 14(3):735.
31. [31]
  ALQUDAMI A, ANNAPOORNI S, GOVIND, SHIVAPRASAD S M. J. Nanopart Res., 2008, 10(6):1027-1036.ALQUDAMI A, ANNAPOORNI S, GOVIND, SHIVAPRASAD S M. J. Nanopart Res., 2008, 10(6):1027-1036.
32. [32]
  SHI Q F, DIAO G W, MU S L. Electrochim. Acta, 2014, 133:335-346.SHI Q F, DIAO G W, MU S L. Electrochim. Acta, 2014, 133:335-346.
33. [33]
  LEE H, SONG C, SEOK Y, HONG Y S, MIN S K, CHO H R. Sci. Adv., 2017, 3(3):1601314.LEE H, SONG C, SEOK Y, HONG Y S, MIN S K, CHO H R. Sci. Adv., 2017, 3(3):1601314.
34. [34]
  YU H L, HE Y. Sen. Actuators, B, 2015, 209:877-882.YU H L, HE Y. Sen. Actuators, B, 2015, 209:877-882.
35. [35]
  CHEN X L, PAN H B, LIU H F, DU M. Electrochim. Acta, 2010, 56(2):636-643.CHEN X L, PAN H B, LIU H F, DU M. Electrochim. Acta, 2010, 56(2):636-643.
36. [36]
  MAYORGA-MARTINEZ C C, GUIX M, MADRID R E, MERKOCI A. Chem. Commun., 2012, 48(11):1686-1688.MAYORGA-MARTINEZ C C, GUIX M, MADRID R E, MERKOCI A. Chem. Commun., 2012, 48(11):1686-1688.
37. [37]
  YUAN M, LIU A P, ZHAO M, DONG W J, ZHAO T Y, WANG J J, TANG W H. Sens. Actuators, B, 2014, 190:707-714.YUAN M, LIU A P, ZHAO M, DONG W J, ZHAO T Y, WANG J J, TANG W H. Sens. Actuators, B, 2014, 190:707-714.
38. [38]
  SAVK A, CELLAT K, ARIKAN K, TEZCAN F, GULBAY S K, KIZILDAG S, ISGIN E S, SEN F. Sci. Rep., 2019, 9:19228.SAVK A, CELLAT K, ARIKAN K, TEZCAN F, GULBAY S K, KIZILDAG S, ISGIN E S, SEN F. Sci. Rep., 2019, 9:19228.
39. [39]
  BO X J, BAI J, YANG L, GUO L P. Sens. Actuators, B, 2011, 157(2):662-668.BO X J, BAI J, YANG L, GUO L P. Sens. Actuators, B, 2011, 157(2):662-668.
40. [40]
  LIN K C, YANG C Y, CHEN S M. Int. J. Electrochem. Sci., 2015, 10(5):3726-3737.LIN K C, YANG C Y, CHEN S M. Int. J. Electrochem. Sci., 2015, 10(5):3726-3737.
41. [41]
  CAO X, WANG N, JIA S, SHAO Y. Anal. Chem., 2013, 85(10):5040-5046.CAO X, WANG N, JIA S, SHAO Y. Anal. Chem., 2013, 85(10):5040-5046.
42. [42]
  MENG Wei-Chen, WANG Qing-Xiang, LI Yan-Zhao, FENG Ling-Zhu, LANG Ming-Fei, CHEN Hong-Shen, SUN Jing. Chin. J. Anal. Chem., 2020, 48(3):363-370. 孟维琛, 王清翔, 李彦钊, 冯凌竹, 郎明非, 陈宏甡, 孙晶. 分析化学, 2020, 48(3):363-370.

扫一扫看文章

计量

PDF下载量: 0
文章访问数: 29
HTML全文浏览量: 4

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

银-金双金属纳米管的可控制备及其对汗液中葡萄糖的无创检测

通讯作者: 常钢,E-mail:changgang@hubu.edu.cn; 何云斌,E-mail:ybhe@hubu.edu.cn

English

Controllable Preparation of Ag-Au Bimetallic Nanotubes for Non-invasive Detection of Glucose in Sweat

Corresponding author: CHANG Gang, ; HE Yun-Bin,

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南：你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

计量

通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

银-金双金属纳米管的可控制备及其对汗液中葡萄糖的无创检测

通讯作者: 常钢,E-mail:changgang@hubu.edu.cn; 何云斌,E-mail:ybhe@hubu.edu.cn

English

Controllable Preparation of Ag-Au Bimetallic Nanotubes for Non-invasive Detection of Glucose in Sweat

Corresponding author: CHANG Gang, ; HE Yun-Bin,

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

计量

文章相关

通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

CCS Chemistry：颜徐州、鲍哲南：你的皮肤可能是一片SPMs