基于行波技术的离子迁移率分离器研制

郭星 赵忠俊 代渐雄 贺飞耀 李宏 王佳宇 刘薇 王昕 张歆雪 杨燕婷 段忆翔

引用本文: 郭星, 赵忠俊, 代渐雄, 贺飞耀, 李宏, 王佳宇, 刘薇, 王昕, 张歆雪, 杨燕婷, 段忆翔. 基于行波技术的离子迁移率分离器研制[J]. 分析化学, 2021, 49(9): 1461-1469. doi: 10.19756/j.issn.0253-3820.210458 shu
Citation:  GUO Xing,  ZHAO Zhong-Jun,  DAI Jian-Xiong,  HE Fei-Yao,  LI Hong,  WANG Jia-Yu,  LIU Wei,  WANG Xin,  ZHANG Xin-Xue,  YANG Yan-Ting,  DUAN Yi-Xiang. Development of A Travelling Wave-based Ion Mobility Spectrometer[J]. Chinese Journal of Analytical Chemistry, 2021, 49(9): 1461-1469. doi: 10.19756/j.issn.0253-3820.210458 shu

基于行波技术的离子迁移率分离器研制

    通讯作者: 段忆翔,E-mail:yduan@scu.edu.cn
  • 基金项目:

    四川省重大科学仪器设备专项(No.2019ZDZX0036)和陕西省重点研究开发计划项目(No.2019ZDLSF01-03)资助。

摘要: 离子迁移谱(Ion mobility spectrometer,IMS)是一种重要的分子碰撞截面分析技术,漂移管是IMS中对样品离子有效分离的核心部件。本工作研制并表征了一种基于行波技术的离子迁移率分离器(Traveling wave ion mobility spectrometer,TWIMS),详细研究并讨论了行波电压幅值、行波移动速度、离子门脉冲宽度以及工作气压对仪器性能的影响。基于理论模拟对上述参数进行实验优化,当行波场电压幅值为50 V、行波场移动速度为162.5 m/s、离子门脉冲宽度为13 ms、工作气压为170 Pa时,此设备能以一种经济简便的方式获得与当前市售行波离子迁移-飞行时间质谱(Traveling wave ion mobilityspectrometer-Time of flight mass spectrometer,TWIMS-TOFMS)联用仪相媲美的迁移率分辨能力。此仪器对利血平的检出限为2.5 ng/mL,线性响应范围高于2个数量级(R2>0.999),性能优于传统IMS谱仪。TWIMS不仅可作为高性能IMS设备独立使用,而且有望与飞行时间质谱仪联用。

English


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  • 收稿日期:  2021-04-23
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