Citation: ZENG Rui-Di, YANG Tong, CHEN Jia-Hui, WANG Dan-Dan, ZHOU Xiao-Shun, SHAO Yong. Selective Recognition of Human Telomeric i-Motif Dimer Over Monomer Using A Disaggregation-Induced Emissive Probe[J]. Chinese Journal of Analytical Chemistry, ;2021, 49(6): 992-998. doi: 10.19756/j.issn.0253-3820.210444 shu

Selective Recognition of Human Telomeric i-Motif Dimer Over Monomer Using A Disaggregation-Induced Emissive Probe

College of Chemistry and Life Sciences, Zhejiang Normal University, Jinhua 321004, China

Corresponding author: SHAO Yong, yshao@zjnu.cn
Received Date: 16 April 2021
Revised Date: 10 May 2021

Fund Project: Supported by the Key Project of Natural Science Foundation of Zhejiang Province (No.LZ20B050001), the Leading Talent Program of Science and Technology Innovation in Zhejiang (No.2020R52022), the National Natural Science Foundation of China (No.21675142), the National Undergraduate Training Program for Innovation and Entrepreneurship (No.201910345027), and the Independent Designing Scientific Research Project of Zhejiang Normal University (No.2020ZS0304).

Due to the important biological activity and wide applications in biosensors and materials chemistry, i-motif structure switching and recognition have attracted more and more attention. In addition, intramolecular i-motif multimers have multiple repeating structural units, which are different from the surrounding environment of i-motif monomers. Although recognition of i-motif monomers by probes has been reported, the selective recognition of i-motif multimers over monomers has yet to be explored. In this work, it is found that hypericin (Hyp) can selectively distinguish human telomeric i-motif dimer from its monomer. The binding of the i-motif dimer depolymerizes the Hyp aggregation and causes a turn-on fluorescence response. However, the Hyp binding has no effect on the stability and conformation of the dimer structure. Since Hyp has a hydrogen bond pattern that is completely complementary to two thymines, the linker length experiment indicates that the in-between space of the two i-motif structural units in the dimer may be the binding site of Hyp via the hydrogen bonding with thymines from the loops. This binding space can effectively bind Hyp only when the i-motif dimer structure is formed under acidic conditions. This work demonstrates that Hyp as a fluorescent probe will play an important role in recognizing i-motif multimers.
- Intramolecular i-motif dimer,
- i-Motif monomer,
- Hypericin,
- Fluorescent probe,
- Selective recognition
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