Citation: ZHANG Jia-Hui, CHEN Yang, LI Jing, ZHAO Jie, ZHANG Zhen, LU Xiao-Quan. Rapid Detection of Copper Ions of Simulated Wilson's Disease Urine Based on Surface-Enhanced Raman Spectroscopy[J]. Chinese Journal of Analytical Chemistry, ;2021, 49(3): 440-448. doi: 10.19756/j.issn.0253-3820.201658 shu

Rapid Detection of Copper Ions of Simulated Wilson's Disease Urine Based on Surface-Enhanced Raman Spectroscopy

ZHANG Jia-Hui ¹ ,
CHEN Yang ¹ ,
LI Jing ¹ ,
ZHAO Jie ¹ ,
ZHANG Zhen ^1,, ,
LU Xiao-Quan ^1,2,,

1.
Tianjin Key Laboratory of Molecular Optoelectronic Science, Department of Chemistry, School of Science, Tianjin University, Tianjin 300072, China;
2.
Key Laboratory of Bioelectrochemistry & Environmental Analysis of Gansu Province, College of Chemistry & Chemical Engineering, Northwest Normal University, Lanzhou 730070, China

Corresponding author: ZHANG Zhen, LU Xiao-Quan,
Received Date: 6 November 2020
Revised Date: 21 December 2020

Fund Project: National Natural Science Foundation of China (Nos.21705117, 21904095).

Wilson's disease (WD) is an autosomal recessive inherited disease. It is characterized by liver cirrhosis and brain degeneration caused by copper (Cu) metabolic disorder, which is one of the few neurogenetic diseases that can be treated, but improper treatment will cause disability or even death. This research constructed a method for detecting Cu²⁺ based on surface-enhanced Raman spectroscopy (SERS). The gold nanorods (AuNRs) substrates modified with 4-mercaptopyridine (Mpy) with uniform morphology and dense hot spots were prepared. Due to the existence of lone pairs of electrons in the nitrogen atom (N) on the pyridine ring, Cu²⁺ could coordinate with it to change the Raman spectrum of Mpy and realized the detection of Cu²⁺ with high sensitivity and selectivity. Under the condition of 25℃ and reaction time of 2 min, the linear range of detection was 4.9×10^-8-1×10^-4 mol/L, with a detection limit of 49 nmol/L(S/N=3). This method was applied to the detection of Cu²⁺ in artificial urine, and the relative standard deviation (RSD) was less than 7.8%. The presented method here was simple, fast and accurate, and the detection process was nondestructive. And it had the potential to be applied to the early diagnosis and treatment of WD in the clinic.
- Surface-enhanced Raman spectroscopy,
- Wilson's disease,
- Gold nanorods,
- Urea,
- Copper ions,
- Coordination compound
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