基于表面增强拉曼光谱技术快速检测铜离子

张嘉惠 陈阳 李静 赵杰 张振 卢小泉

引用本文: 张嘉惠, 陈阳, 李静, 赵杰, 张振, 卢小泉. 基于表面增强拉曼光谱技术快速检测铜离子[J]. 分析化学, 2021, 49(3): 440-448. doi: 10.19756/j.issn.0253-3820.201658 shu
Citation:  ZHANG Jia-Hui,  CHEN Yang,  LI Jing,  ZHAO Jie,  ZHANG Zhen,  LU Xiao-Quan. Rapid Detection of Copper Ions of Simulated Wilson's Disease Urine Based on Surface-Enhanced Raman Spectroscopy[J]. Chinese Journal of Analytical Chemistry, 2021, 49(3): 440-448. doi: 10.19756/j.issn.0253-3820.201658 shu

基于表面增强拉曼光谱技术快速检测铜离子

    通讯作者: 张振,E-mail:zhzhen@tju.edu.cn; 卢小泉,E-mail:luxq@nwnu.edu.cn
  • 基金项目:

    国家自然科学基金项目(Nos.21705117,21904095)资助。

摘要: 肝豆状核变性(WD)是一种常染色体隐性遗传疾病,以因铜(Cu)代谢障碍引起的肝硬化以及因基底节损害为主造成的脑变性为特征,是少数可治愈的神经性遗传疾病之一。本研究建立了一种基于表面增强拉曼光谱(SERS)技术检测Cu2+的方法。制备了形貌均一、热点密集的金纳米棒(AuNRs)基底,并在其表面修饰4-巯基吡啶(Mpy),由于Mpy中吡啶环上的氮原子存在孤对电子,Cu2+与其配位,并使其拉曼光谱发生变化,据此实现高灵敏度、高选择性检测Cu2+。优化了反应条件,在25℃、反应2 min的条件下,Cu2+的线性检测范围为4.9×10-8~1×10-4 mol/L,检出限为49 nmol/L。将本方法应用于人工尿液中Cu2+的检测,相对标准偏差<7.8%。本方法操作简单、快速准确、检测过程无损,在WD的早期临床诊断与治疗方面具有良好的应用潜力。

English


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  • 收稿日期:  2020-11-06
  • 修回日期:  2020-12-21
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