基于铜基金属有机框架的液栅型石墨烯晶体管高灵敏检测葡萄糖

陶甜 叶嵩 马明宇 高难 蔡志伟 刘旭 常钢 何云斌

引用本文: 陶甜, 叶嵩, 马明宇, 高难, 蔡志伟, 刘旭, 常钢, 何云斌. 基于铜基金属有机框架的液栅型石墨烯晶体管高灵敏检测葡萄糖[J]. 分析化学, 2021, 49(3): 387-396. doi: 10.19756/j.issn.0253-3820.201594 shu
Citation:  TAO Tian,  YE Song,  MA Ming-Yu,  GAO Nan,  CAI Zhi-Wei,  LIU Xu,  CHANG Gang,  HE Yun-Bin. Highly Sensitive Detection of Glucose Using Solution-gated Graphene Transistor Based on Copper-Metal Organic Framework[J]. Chinese Journal of Analytical Chemistry, 2021, 49(3): 387-396. doi: 10.19756/j.issn.0253-3820.201594 shu

基于铜基金属有机框架的液栅型石墨烯晶体管高灵敏检测葡萄糖

    通讯作者: 常钢,E-mail:changgang@hubu.edu.cn; 何云斌,E-mail:ybhe@hubu.edu.cn
  • 基金项目:

    国家自然科学基金项目(Nos.51672074,11774082,11975093)、湖北省自然科学基金项目(No.2019CFA006)和武汉市应用基金前沿项目(No.201801041011287)资助。#共同第一作者

摘要: 将金属有机框架(Metal-organic frameworks,MOFs)材料的电催化活性和液栅型石墨烯晶体管(Solution-gated graphene transistor,SGGT)的信号放大作用结合,构建了一种新型SGGT无酶葡萄糖传感器。以均苯三甲酸(BTC)为有机配体,采用溶剂热法合成铜基MOF材料(Cu-BTC),利用Nafion膜将Cu-BTC材料固定到玻碳电极上,并作为栅极,以单层石墨烯作为晶体管沟道。此传感器的传感机理是基于葡萄糖在修饰有Cu-BTC的栅电极上发生电化学反应,引起施加于SGGT的有效栅电压的变化,从而改变了沟道载流子浓度和沟道电流。由于Cu-BTC对葡萄糖良好的电催化活性及SGGT的高灵敏度,Cu-BTC修饰的SGGT传感器对葡萄糖表现出优异的传感性能,线性范围为1 nmol/L~40 mmol/L,检出限低至1 nmol/L,优于大多数传统葡萄糖检测方法。同时,此传感器对汗液和血液中的主要成分(如尿素、乳酸、多巴胺、抗坏血酸、尿酸等)表现出较好的抗干扰性能,在长期重复实验中表现出良好的稳定性,并成功应用于人体汗液中葡萄糖的检测。Cu-BTC修饰的SGGT传感器有望应用于糖尿病治疗和临床监测中的葡萄糖无酶无创检测。

English


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  • 收稿日期:  2020-10-09
  • 修回日期:  2021-01-06
通讯作者: 陈斌, bchen63@163.com
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