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基于微流控芯片的外泌体分离与检测

匡晶晶 ,  康璐 ,  林楚慧 ,  王月荣 ,  张敏 ,  章弘扬 ,  胡坪

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引用本文: 匡晶晶, 康璐, 林楚慧, 王月荣, 张敏, 章弘扬, 胡坪. 基于微流控芯片的外泌体分离与检测[J]. 分析化学, 2021, 49(9): 1437-1450. doi: 10.19756/j.issn.0253-3820.201568 shu
Citation:  KUANG Jing-Jing,  KANG Lu,  LIN Chu-Hui,  WANG Yue-Rong,  ZHANG Min,  ZHANG Hong-Yang,  Hu Ping. Separation and Detection of Exosomes Based on Microfluidic Chip[J]. Chinese Journal of Analytical Chemistry, 2021, 49(9): 1437-1450. doi: 10.19756/j.issn.0253-3820.201568 shu

基于微流控芯片的外泌体分离与检测

  • 1.

    华东理工大学化学与分子工程学院, 上海市功能性材料化学重点实验室, 上海 200237;

  • 2.

    华东理工大学药学院, 上海市新药设计重点实验室, 上海 200237

    • 通讯作者: 胡坪,E-mail:huping@ecust.edu.cn
  • 基金项目:

    国家自然科学基金项目（No.81973285）资助。

摘要: 外泌体作为最小的细胞外囊泡，内含有脂质、蛋白质、mRNA、microRNA以及双链DNA，可被大多数细胞分泌并在体液中循环，参与细胞间的通讯。近年的研究发现，外泌体在肿瘤发生、迁移、生长、组织损伤修复、免疫抗原呈递及神经退行性疾病中发挥了极其重要的作用，可作为相关疾病诊断的生物标志物，因此，外泌体的分离和检测技术的研究至关重要。本文总结了近年来基于微流控芯片的外泌体分离和检测方法的研究进展。

English


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  • 收稿日期:  2020-09-21
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