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Citation: JIA Er-Na, LIN Yuan, SU Zhao-Hui. Effect of Protein Covalent Grafting on Blood Compatibility of Titanium Dioxide Nanotubes[J]. Chinese Journal of Analytical Chemistry, ;2021, 49(1): 121-127. doi: 10.19756/j.issn.0253-3820.201544 shu

Effect of Protein Covalent Grafting on Blood Compatibility of Titanium Dioxide Nanotubes

JIA Er-Na ^1,2 ,
LIN Yuan ^1,, ,
SU Zhao-Hui ^1,2,,

1.
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China;
2.
University of Science and Technology of China, Hefei 230026, China

Corresponding author: LIN Yuan, SU Zhao-Hui,
Received Date: 8 September 2020
Revised Date: 22 September 2020

Fund Project: Supported by the National Natural Science Foundation of China (No.21429401) and the Chinese Scholarship Council (No.201904910172).

The adsorption behavior of proteins in blood on the surface of the contact material is an important factor affecting the blood compatibility of the implanted material. In order to establish the relationship between protein conformation and blood compatibility, the surfaces of amino and carboxyl groups on the titanium dioxide nanotubes were fabricated by grafting silane coupling agent, and bovine serum albumin (BSA) and fibrinogen (Fib) were fixed to the surface through EDC/NHS chemical crosslinking. The relationship between the secondary structure changes of BSA and Fib and platelet adhesion behavior was investigated by studying protein adsorption and surface platelet adhesion behavior. The results showed that the ratios of β-sheet to β-turn in the secondary structure of proteins on the surface of carboxyl immobilized-BSA and amino immobilized Fib were higher, and the blood compatibility was better. Furthermore, BSA adhesion to platelets was selective, the amino-binding protein led to exposure of specific receptors that recognize platelets, and platelet activation increased.
- Titanium oxide nanotubes,
- Protein adsorption,
- Conformation change,
- Platelet adhesion
1. [1]
2. [2]
3. [3]
4. [4]
5. [5]
6. [6]
7. [7]
8. [8]
9. [9]
10. [10]
11. [11]
12. [12]
13. [13]
14. [14]
15. [15]
16. [16]
17. [17]
18. [18]
19. [19]
20. [20]
21. [21]
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