射频四极杆离子导向用于质子转移反应飞行时间质谱的传输特性研究

引用本文: 贺飞耀, 刘泽平, 代渐雄, 李雯雯, 郭星, 付玉, 岳寒露, 李宏, 邓辅龙, 赵忠俊, 段忆翔. 射频四极杆离子导向用于质子转移反应飞行时间质谱的传输特性研究[J]. 分析化学, 2021, 49(3): 359-365. doi: 10.19756/j.issn.0253-3820.201519 shu

Citation: HE Fei-Yao, LIU Ze-Ping, DAI Jian-Xiong, LI Wen-Wen, GUO Xing, FU Yu, YUE Han-Lu, LI Hong, DENG Fu-Long, ZHAO Zhong-Jun, DUAN Yi-Xiang. Study on Transmission Characteristics of Radio Frequency Quadrupole Ion Guide for Proton Transfer Reaction Time-of-Flight Mass Spectrometry[J]. Chinese Journal of Analytical Chemistry, 2021, 49(3): 359-365. doi: 10.19756/j.issn.0253-3820.201519 shu

射频四极杆离子导向用于质子转移反应飞行时间质谱的传输特性研究

贺飞耀 ^1, ,
刘泽平 ^2, ,
代渐雄 ^3, ,
李雯雯 ^4, ,
郭星 ^3, ,
付玉 ^5, ,
岳寒露 ^1, ,
李宏 ^1, ,
邓辅龙 ^1, ,
赵忠俊 ^{6,
,} ,
段忆翔 ^{1,7,
,}

1.
四川大学生命科学学院, 成都 610064;
2.
中核霞浦核电有限公司, 宁德 355100;
3.
西北大学化学与材料科学学院, 西安 710127;
4.
四川大学华西公共卫生学院, 成都 610064;
5.
四川大学机械工程学院, 成都 610064;
6.
四川大学化学工程学院, 成都 610064;
7.
成都艾立本科技有限公司, 成都 610064

通讯作者: 赵忠俊,E-mail:tompson_2006@163.com; 段忆翔,E-mail:yduan@scu.edu.cn

基金项目:
四川省重大科学仪器设备专项项目（No.2019ZDZX0036）资助。

摘要: 射频四极杆离子导向器（RF-QIG）具有结构简单、传输效率高等优点，被广泛应用于各类质谱系统中。本研究将自主研制的RF-QIG集成于质子转移反应飞行时间质谱（PTR-TOF MS），考察了此装置在不同工作频率及电压幅值下对不同质荷比（m/z）离子的传输特性。结果表明，此RF-QIG在频率低于1 MHz时，无法传输m/z<40的离子，而H₃O⁺（m/z 19）和H₂O·H₃O⁺（m/z 37）在2.48和3.43 MHz频率下获得了非常强的质谱信号。此外，对于较高质量数的离子，如[C₃H₆O+H]⁺（m/z 59）、[C₆H₆+H]⁺（m/z 79）和[C₇H₈+H]⁺（m/z 93），均在2.48 MHz获得最强信号。MATLAB对有效电势的求解结果表明，电压幅值不变时，频率越高，有效电势越低。采用PTR-QIG-TOF MS对实验室背景空气进行了检测，效果良好，表明RF-QIG可满足实际应用需求。

关键词:

English

Study on Transmission Characteristics of Radio Frequency Quadrupole Ion Guide for Proton Transfer Reaction Time-of-Flight Mass Spectrometry

1.
College of Life Science, Sichuan University, Chengdu 610064, China;
2.
China Nuclear Xiapu Nuclear Power Co., Ltd, Ningde 355100, China;
3.
College of Chemistry and Materials Science, Northwest University, Xi'an 710127, China;
4.
West China School of Public Health, Sichuan University, Chengdu 610064, China;
5.
School of Mechanical Engineering, Sichuan University, Chengdu 610064, China;
6.
School of Chemical Engineering, Sichuan University, Chengdu 610064, China;
7.
Aliben Science & Technology CO., LTD, Chengdu 610064, China

Corresponding author: ZHAO Zhong-Jun, ; DUAN Yi-Xiang,

Received Date: 27 August 2020
Revised Date: 20 December 2020
Fund Project:
Special Project of Major Scientific Instruments and Equipment in Sichuan Province (No.2019ZDZX0036).

Abstract: Radio frequency quadrupole ion guide (RF-QIG) is widely used in various mass spectrometry systems because of its simple structure and high transmission efficiency. In this study, the self-developed RF-QIG was successfully integrated into the proton transfer reaction time-of-flight mass spectrometry (PTR-TOF MS). Through the adjustment of variable radio frequency electric field, the transmission characteristics of the device in ions with different mass-charge ratio (m/z) at different operating frequencies and voltage amplitudes were investigated. The results showed that when the frequency was less than 1 MHz, the RF-QIG reported here couldn't transport ions with m/z less than 40, while H₃O⁺ (m/z 19) and H₂O·H₃O⁺ (m/z 37) could obtain strong MS signals at 2.48 MHz and 3.43 MHz. In addition, for the ions with higher m/z, such as[C₃H₆O+H]⁺ (m/z 59),[C₆H₆+H]⁺ (m/z 79) and[C₇H₈+H]⁺ (m/z 93), the strongest signals were all obtained at 2.48 MHz. The results of MATLAB's numerical solution of the effective potential showed that when the voltage amplitude was constant, the higher the frequency was given, the lower the effective potential was obtained. Finally, the successful detection of the background air in the laboratory showed that RF-QIG could be used in the ion transportation of PTR-TOF MS system.

Key words:

Ion guide
/ Radio frequency quadrupole
/ Proton transfer reaction mass spectrometer
/ Time-of-flight mass spectrometry

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1.
沈阳化工大学材料科学与工程学院沈阳 110142

射频四极杆离子导向用于质子转移反应飞行时间质谱的传输特性研究

通讯作者: 赵忠俊,E-mail:tompson_2006@163.com; 段忆翔,E-mail:yduan@scu.edu.cn

English

Study on Transmission Characteristics of Radio Frequency Quadrupole Ion Guide for Proton Transfer Reaction Time-of-Flight Mass Spectrometry

Corresponding author: ZHAO Zhong-Jun, ; DUAN Yi-Xiang,

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

射频四极杆离子导向用于质子转移反应飞行时间质谱的传输特性研究

通讯作者: 赵忠俊,E-mail:tompson_2006@163.com; 段忆翔,E-mail:yduan@scu.edu.cn

English

Study on Transmission Characteristics of Radio Frequency Quadrupole Ion Guide for Proton Transfer Reaction Time-of-Flight Mass Spectrometry

Corresponding author: ZHAO Zhong-Jun, ; DUAN Yi-Xiang,

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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