基于联合荧光机制的激发态分子内质子转移荧光探针研究进展

引用本文: 卢先林, 何炜. 基于联合荧光机制的激发态分子内质子转移荧光探针研究进展[J]. 分析化学, 2021, 49(2): 184-196. doi: 10.19756/j.issn.0253-3820.201512 shu

Citation: LU Xian-Lin, HE Wei. Research Advances in Excited State Intramolecular Proton Transfer Fluorescent Probes Based on Combined Fluorescence Mechanism[J]. Chinese Journal of Analytical Chemistry, 2021, 49(2): 184-196. doi: 10.19756/j.issn.0253-3820.201512 shu

基于联合荧光机制的激发态分子内质子转移荧光探针研究进展

卢先林 ,
何炜 ^,

空军军医大学药学系化学制药学教研室, 西安 710032

通讯作者: 何炜,E-mail:weihechem@fmmu.edu.cn

基金项目:
科技部"重大新药创制课题"项目（No.2014ZX09J14104-06C）和陕西省重点研发计划项目（No.S2019ZDLSF03-03）资助。

摘要: 荧光探针能够实现对分析物的快速检测，并因其优异的选择性、高灵敏度和操作简便等优点成为近年的研究热点。激发态分子内质子转移（ESIPT）是最基础的荧光设计策略之一，基于ESIPT原理设计的荧光探针具有发光强度高、Stokes位移大以及反应过程可逆等优点，但也存在对环境敏感、发射波段较短等不足。近年来，将ESIPT与其它荧光机制联用，可得到具有双重荧光响应机制的新型荧光探针。此联合设计策略不仅可弥补单一ESIPT荧光团的不足，还实现了多荧光信号通道，并可显著提高探针的选择性和灵敏度。本文总结了近年来将光致电子转移（PET）、聚集诱导荧光（AIE）、荧光共振能量转移（FRET）、分子内电荷转移（ICT）荧光机制引入到ESIPT荧光团设计得到的荧光探针，并分析了其在检测离子、小分子、生物大分子等方面的检测机理以及成像应用研究的进展。

关键词:

English

Research Advances in Excited State Intramolecular Proton Transfer Fluorescent Probes Based on Combined Fluorescence Mechanism

LU Xian-Lin ,
HE Wei ^,

School of Pharmacy, Air Force Medical University, Xi'an 710032, China

Corresponding author: HE Wei, weihechem@fmmu.edu.cn

Received Date: 24 August 2020
Revised Date: 02 November 2020
Fund Project:
Supported by the Shaanxi Province Key Research and Development Program (No. S2019ZDLSF03-03) and the National Science and Technology Major Project of China on "Key New Drug Creation and Development Program" (No.2014ZX09J14104-06C).

Abstract: Fluorescent probes can achieve rapid detection of analytes, and have become a research hotspot in recent years due to their excellent selectivity, high sensitivity and easy operation. Excited state intramolecular proton transfer (ESIPT) is one of the most basic strategies for designing fluorescence probes. Fluorescent probes based on ESIPT possess large Stokes shift, strong luminescence and high fluorescence quantum yield. However, there are still some disadvantages, such as sensitivity to the environment and short emission wavelength. In recent years, the combination of ESIPT with other fluorescence mechanisms has obtained new fluorescent probes with dual mechanism of fluorescence response. This strategy can not only solve the shortage of ESIPT fluorophore, but also realize multi-fluorescence signal channel, and significantly improves the selectivity and sensitivity of the new probe. In this review, we mainly analyze the detection mechanism and imaging application of fluorescence probes of photoinduced electron transfer (PET)-ESIPT, intramolecular charge transfer (ICT)-ESIPT, fluorescence resonance energy transfer (FRET)-ESIPT, aggregation-induced emission (AIE)-ESIPT for ions, small molecules, biological macromolecules in recent years.

Key words:

Fluorescence probe
/ Combined fluorescence mechanism
/ Excited state intramolecular proton transfer
/ Review

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1.
沈阳化工大学材料科学与工程学院沈阳 110142

基于联合荧光机制的激发态分子内质子转移荧光探针研究进展

通讯作者: 何炜,E-mail:weihechem@fmmu.edu.cn

English

Research Advances in Excited State Intramolecular Proton Transfer Fluorescent Probes Based on Combined Fluorescence Mechanism

Corresponding author: HE Wei, weihechem@fmmu.edu.cn

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

基于联合荧光机制的激发态分子内质子转移荧光探针研究进展

通讯作者: 何炜,E-mail:weihechem@fmmu.edu.cn

English

Research Advances in Excited State Intramolecular Proton Transfer Fluorescent Probes Based on Combined Fluorescence Mechanism

Corresponding author: HE Wei, weihechem@fmmu.edu.cn

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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