基于碳量子点荧光开启检测还原性生物小分子的研究进展

引用本文: 张昊晨, 郭永明. 基于碳量子点荧光开启检测还原性生物小分子的研究进展[J]. 分析化学, 2021, 49(1): 14-23. doi: 10.19756/j.issn.0253-3820.201349 shu

Citation: ZHANG Hao-Chen, GUO Yong-Ming. Advances of Carbon Quantum Dots for Fluorescence Turn-on Detection of Reductive Small Biomolecules[J]. Chinese Journal of Analytical Chemistry, 2021, 49(1): 14-23. doi: 10.19756/j.issn.0253-3820.201349 shu

基于碳量子点荧光开启检测还原性生物小分子的研究进展

张昊晨 ,
郭永明 ^,

南京信息工程大学化学与材料学院, 南京 210044

通讯作者: 郭永明,E-mail:chinahenangm@163.com

基金项目:
南京信息工程大学人才启动项目（No.2018r056）、南京信息工程大学大学生创新创业训练计划项目（No.201910300209）和南信大-雷丁大学国际联合研究院开放课题资助。

摘要: 人体内的生物分子参与许多重要的生命活动，特别是一些具有还原性的生物小分子，对维持人体健康和抵御疾病具有重要作用，因此，还原性生物小分子的快速准确检测具有重要意义，其中荧光开启（Fluorescence turn-on）检测是一种灵敏度高、操作简便的检测方法。碳量子点（CQDs）是近年出现的一种结构新颖的零维荧光碳纳米材料，具有生物兼容性好、毒性低、易制备、价格低、光稳定性好、荧光量子产率高等优点，在还原性生物小分子荧光开启检测方面极具应用潜力。本文重点介绍了近三年CQDs在葡萄糖、抗坏血酸、多巴胺、生物硫醇、尿酸荧光开启检测中的研究进展，并对CQDs在这些生物小分子荧光开启检测中面临的机遇与挑战进行了论述。

关键词:

碳量子点
/ 生物小分子
/ 荧光
/ 检测
/ 评述

English

Advances of Carbon Quantum Dots for Fluorescence Turn-on Detection of Reductive Small Biomolecules

ZHANG Hao-Chen ,
GUO Yong-Ming ^,

School of Chemistry and Materials Science, Nanjing University of Information Science & Technology, Nanjing 210044, China

Corresponding author: GUO Yong-Ming, chinahenangm@163.com

Received Date: 15 June 2020
Revised Date: 18 September 2020
Fund Project:
Supported by the Startup Foundation for Introducing Talent of NUIST (No. 2018r056), the Innovation and Entrepreneurship Training Program for College Students of NUIST (No. 201910300209) and the Foundation of NUIST-UoR International Research Institute.

Abstract: Small biomolecules in human body involve in many important life activities, especially some small reductive biomolecules, and play important roles in maintaining human health and resisting diseases. Therefore, the rapid and accurate detection of small reductive biomolecules is of great significance. The fluorescence turn-on detection is a sensitive detection method with ease of operation. Carbon quantum dots (CQDs) are a novel zero-dimensional fluorescent carbon nanomaterial, which exhibit many advantages including good biocompatibility, low toxicity, ease of fabrication, low cost, good photostability and high fluorescence quantum yield, therefore, CQDs have great potential in the fluorescence turn-on detection of small biomolecules. In this paper, we summarized the development of CQDs in fluorescence turn-on detection of glucose, ascorbic acid, dopamine, biothiols and uric acid in recent three years. Finally, we discussed the opportunities and challenges of CQDs in the fluorescence turn-on detection of these small biomolecules.

Key words:

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1.
沈阳化工大学材料科学与工程学院沈阳 110142

基于碳量子点荧光开启检测还原性生物小分子的研究进展

通讯作者: 郭永明,E-mail:chinahenangm@163.com

English

Advances of Carbon Quantum Dots for Fluorescence Turn-on Detection of Reductive Small Biomolecules

Corresponding author: GUO Yong-Ming, chinahenangm@163.com

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

基于碳量子点荧光开启检测还原性生物小分子的研究进展

通讯作者: 郭永明,E-mail:chinahenangm@163.com

English

Advances of Carbon Quantum Dots for Fluorescence Turn-on Detection of Reductive Small Biomolecules

Corresponding author: GUO Yong-Ming, chinahenangm@163.com

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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