Citation: ZHANG Hai-jing, XIE Lin-na, WANG Qin, XU Chun-yu, XU Dong-qun, ZHU Ying. Determination of Perfluoroalkyl Acids and Alternatives in Atmospheric Fine Particles by Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry[J]. Chinese Journal of Analytical Chemistry, ;2022, 50(4): 623-633. doi: 10.19756/j.issn.0253-3820.201269 shu

Determination of Perfluoroalkyl Acids and Alternatives in Atmospheric Fine Particles by Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry

National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China

Corresponding author: XU Dong-qun, ZHU Ying,
Received Date: 13 May 2020
Revised Date: 11 March 2022

Fund Project: Supported by the Public Welfare Research Program of the National Health and Family Planning Commission of China (No. 201402022)

A ultra performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS) method was developed for determination of perfluoroalkyl acids and alternatives of perfluorooctane sulfonate(PFOS) in atmospheric fine particles(PM_2.5).Half of filter was cut into small pieces and extracted by methanol for 3 times at 40℃.The extraction solutions were combined and the supernatant was purified by ENVI-Carb SPE cartridge.The effluent was dried by nitrogen at 40℃, re-dissolved with 0.2 mL of methanol, and centrifuged, and the supernatants were quantitatively analyzed in multiple reactions monitoring mode by mass spectrometry with electro-spray ionization in negative mode.The method showed a good linearity for detection of 22 compounds, with the correlation coefficients of more than 0.9980, the limits of detection of 0.01-0.52 pg/m³, the limits of quantification of 0.03-1.74 pg/m³, the spiked recoveries of 78.6%-119.3% and the relative standard deviations of 1.7%-10.5%.The PFAAs and alternatives of PFOS in PM_2.5 collected in November 2019 in Beijing were determined by the method.Four kinds of PFAAs were detected in 29 samples, including PFOA, PFHp A, PFOS and PFHx A, and the detection rates were 100%, 79.3%, 62.1% and 58.6%, respectively.The concentrations were in the range of 1.94-86.9 pg/m³, 0.31-4.39 pg/m³, 0.29-3.51 pg/m³ and 0.36-1.69 pg/m³, respectively.
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