基于纳米孔器件的光响应分子的应用

引用本文: 唐婧, 王森, 吴吉, 梁丽媛, 王亮, 王德强. 基于纳米孔器件的光响应分子的应用[J]. 分析化学, 2020, 48(11): 1458-1466. doi: 10.19756/j.issn.0253-3820.201247 shu

Citation: TANG Jing, WANG Sen, WU Ji, LIANG Li-Yuan, WANG Liang, WANG De-Qiang. Applications of Photo-Responsive Molecules in Nanopore-based Devices[J]. Chinese Journal of Analytical Chemistry, 2020, 48(11): 1458-1466. doi: 10.19756/j.issn.0253-3820.201247 shu

基于纳米孔器件的光响应分子的应用

唐婧 ^1,2, ,
王森 ^1,2, ,
吴吉 ^1,2, ,
梁丽媛 ^{1,
,} ,
王亮 ^1, ,
王德强 ^{1,
,}

1.
中国科学院重庆绿色智能技术研究院, 重庆 400714;
2.
中国科学院大学重庆学院, 重庆 400714

通讯作者: 梁丽媛,liangliyuan@cigit.ac.cn; 王德强,dqwang@cigit.ac.cn

基金项目:
本文系重庆市自然科学基金项目（No.cstc2017jcyjB0105）、中国科学院青年创新促进会项目（No.2017392）和中国科学院大学重庆学院资助

摘要: 探索生物大分子和小分子的构象以及它们在外界环境中的响应和作用规律对理解有机质的结构与性能的关系十分重要。纳米孔作为新兴的第三代单分子基因测序技术，可以实时监测待测物分子的构象变化过程，在单分子检测及核酸和蛋白测序方面展现了良好的应用前景。为了进一步提高检测的分辨率和精确度，可以采用光电联合检测方法，通过引入光响应分子以满足更高的检测需求。本文综述了目前纳米孔器件的研究进展以及代表性光响应分子在纳米孔检测系统中的设计与应用，主要介绍了偶氮苯及其衍生物、螺吡喃和二芳基乙烯三类光响应分子分别在生物孔和固态孔中的光响应性能。光调控是一种操作简捷有效的分子结构监控方式，其与纳米孔检测技术的结合在单分子识别方面的应用潜力对多功能纳米器件的设计与应用具有重要的指导意义。

关键词:

English

Applications of Photo-Responsive Molecules in Nanopore-based Devices

1.
Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing 400714, China;
2.
Chongqing School, University of Chinese Academy of Sciences, Chongqing 400714, China

Corresponding author: LIANG Li-Yuan, ; WANG De-Qiang,

Received Date: 30 April 2020
Revised Date: 09 June 2020
Fund Project:
This work was supported by the Natural Science Foundation of Chongqing, China (No. cstc2017jcyjB0105), the Youth Innovation Promotion Association (No. 2017392) and the University of Chinese Academy of Sciences.

Abstract: In biochemistry, exploring the conformation, response to external environment and interaction rules of biomacromolecules and small molecules is crucial to understanding the correlation of structures and properties among organic matters. However, it is a challenge for the traditional techniques to observe the conformation heterogeneity and interpret the interaction mechanism of the biomolecules in living cells. As the emerged third generation single-molecule gene sequencing technology, nanopore can monitor the conformation change of the molecules in situ and therefore demonstrates good applications in single-molecule sensing and nucleic acid and protein sequencing. To further improve the detection resolution and precision, the combined photoelectric detection can achieve higher accuracy via introducing optical-responsive molecules. In view of the extensive applications and development status of nanopore technique in single-molecule conformation resolution, this paper summarizes the research progress of the nanopore devices and the design and applications of some typical photo-responsive molecules in nanopore sensing, including azobenzenes and their derivatives, spiropyrane and diarylethene. Light regulation is a simple and effective approach for monitoring the molecular structures, and further integration with nanopore devices exhibits great potential in single-molecule detection meanwhile sheds light on the design and applications of multi-responsive nano-devices.

Key words:

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

基于纳米孔器件的光响应分子的应用

通讯作者: 梁丽媛,liangliyuan@cigit.ac.cn; 王德强,dqwang@cigit.ac.cn

English

Applications of Photo-Responsive Molecules in Nanopore-based Devices

Corresponding author: LIANG Li-Yuan, ; WANG De-Qiang,

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

基于纳米孔器件的光响应分子的应用

通讯作者: 梁丽媛,liangliyuan@cigit.ac.cn; 王德强,dqwang@cigit.ac.cn

English

Applications of Photo-Responsive Molecules in Nanopore-based Devices

Corresponding author: LIANG Li-Yuan, ; WANG De-Qiang,

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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通讯作者: 陈斌, bchen63@163.com

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