苯基异丙基-酰胺系列合成大麻素质谱特征的研究

钱振华 贾薇 刘翠梅

引用本文: 钱振华, 贾薇, 刘翠梅. 苯基异丙基-酰胺系列合成大麻素质谱特征的研究[J]. 分析化学, 2020, 48(11): 1564-1572. doi: 10.19756/j.issn.0253-3820.201127 shu
Citation:  QIAN Zhen-Hua,  JIA Wei,  LIU Cui-Mei. Analysis of Fragmentation Pathways of Cumyl-Carboxamide Synthetic Cannabinoids New Psychoactive Substances[J]. Chinese Journal of Analytical Chemistry, 2020, 48(11): 1564-1572. doi: 10.19756/j.issn.0253-3820.201127 shu

苯基异丙基-酰胺系列合成大麻素质谱特征的研究

    通讯作者: 刘翠梅,liucuimei8258@163.com
摘要: 采用气相色谱-质谱联用(GC-MS)法和超高效液相色谱-串联四极杆飞行时间质谱(UPLC-QTOF-MS)法对新一代合成大麻素苯基异丙基(CUMYL)-酰胺系列化合物进行分析。GC-MS分析采用Aglient DB-5MS石英毛细管色谱柱(30 m×0.25 mm×0.25 μm),以140℃为初温进行程序升温,在电子轰击源(EI)模式下采集数据;UPLC-QTOF-MS分析采用Waters Acquity UPLC BEH C18色谱柱(100 mm×2.1 mm,1.7 μm),以0.1%甲酸(A)-乙腈(B)为流动相进行梯度洗脱,在电喷雾正离子(ESI+)-碰撞诱导解离(CID)模式下采集数据。通过总结此类物质在两种模式下获得的碎片离子与分子结构的关系,推测其可能的碎裂途径,并归纳了通过特征性离子快递筛查未知CUMYL-酰胺系列合成大麻素的方法,为此类物质的鉴定提供了参考。

English


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  • 收稿日期:  2020-03-12
  • 修回日期:  2020-09-08
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