苯基异丙基-酰胺系列合成大麻素质谱特征的研究

钱振华 贾薇 刘翠梅

引用本文: 钱振华, 贾薇, 刘翠梅. 苯基异丙基-酰胺系列合成大麻素质谱特征的研究[J]. 分析化学, 2020, 48(11): 1564-1572. doi: 10.19756/j.issn.0253-3820.201127 shu
Citation:  QIAN Zhen-Hua,  JIA Wei,  LIU Cui-Mei. Analysis of Fragmentation Pathways of Cumyl-Carboxamide Synthetic Cannabinoids New Psychoactive Substances[J]. Chinese Journal of Analytical Chemistry, 2020, 48(11): 1564-1572. doi: 10.19756/j.issn.0253-3820.201127 shu

苯基异丙基-酰胺系列合成大麻素质谱特征的研究

    通讯作者: 刘翠梅,liucuimei8258@163.com
摘要: 采用气相色谱-质谱联用(GC-MS)法和超高效液相色谱-串联四极杆飞行时间质谱(UPLC-QTOF-MS)法对新一代合成大麻素苯基异丙基(CUMYL)-酰胺系列化合物进行分析。GC-MS分析采用Aglient DB-5MS石英毛细管色谱柱(30 m×0.25 mm×0.25 μm),以140℃为初温进行程序升温,在电子轰击源(EI)模式下采集数据;UPLC-QTOF-MS分析采用Waters Acquity UPLC BEH C18色谱柱(100 mm×2.1 mm,1.7 μm),以0.1%甲酸(A)-乙腈(B)为流动相进行梯度洗脱,在电喷雾正离子(ESI+)-碰撞诱导解离(CID)模式下采集数据。通过总结此类物质在两种模式下获得的碎片离子与分子结构的关系,推测其可能的碎裂途径,并归纳了通过特征性离子快递筛查未知CUMYL-酰胺系列合成大麻素的方法,为此类物质的鉴定提供了参考。

English


    1. [1]

      Seely K A, Lapoint J, Moran J H, Fattore L. Prog. Neuropsychopharmacol. Biol. Psychiat.,2012,39(2):234-243

    2. [2]

      United Nations Office for Drugs and Crime (UNODC).2018,https://www.unodc.org/wdr2018/

    3. [3]

      European Monitoring Centre for Drugs and Drug Addiction (EMCDDA). 2017,http://www.emcdda.europa.eu/topics/pods/syntheticcannabinoids

    4. [4]

      Advisory Council on the Misuse of Drugs (ACMD).2009,http://www.namsdl.org/library/E2E91AB8-1372-636C-DDFC2BA64093B64C/

    5. [5]

      van Amsterdam J, Nutt D, van den Brink W. J. Psychopharmacol.,2013,27(3):317-324

    6. [6]

      Sekuła K, Zuba D, Stanaszek R. J. Mass Spectrom.,2012,47(5):632-643

    7. [7]

      Huppertz L M, Kneisel S, Auwaerter V, Kempf J. J. Mass Spectrom.,2014,49(2):117-127

    8. [8]

      Mazzarino M, de la Torre X, Botrè F. Anal. Chim. Acta,2014,837:70-82

    9. [9]

      Akamatsu S, Yoshida M. J. Mass Spectrom.,2016,51(1):28-32

    10. [10]

      Sekuła K, Zuba D, Lorek K. J. Am. Soc. Mass Spectrom.,2018,29:1941-1950

    11. [11]

      Hong J, Hur J, Lee W W, Kim B H, Kim H J, Lee D H, Lee J, Lee Y M, Oh H B. Anal. Methods,2019,11(41):5260-5273

    12. [12]

      http://www.caymanchem.com/forensics/search/productSearch

    13. [13]

      Bovens M G, Bissig C, Staeheli S N, Poetzsch M, Pfeiffer B, Kraemer T. Forensic Sci. Int.,2017,281:98-105

    14. [14]

      Ölmez N A, Kapucu H, Altun N C, Eren B. Forensic Toxicol.,2018,36(1):192-199

    15. [15]

      Angerer V, Mogler L, Steitz J P, Bisel P, Hess C, Schoeder C T, Müller C E, Huppertz L M, Westphal F, Schäper J, Auwärter V. Drug Test Anal.,2018,10(3):597-603

    16. [16]

      Nash C, Glowacki L, Gerostamoulos D, Pigou P, Scott T, Kostakis C. Drug Test Anal.,2019,11(10):1480-1485

    17. [17]

      Ernsta L, Brandhorstb K, Papkec U, Altrogged A, Zodeld S, Langerd N, Beuerle T. Forensic Sci. Int.,2017,277:51-58

    18. [18]

      Dobaja M, Grenc D, Kozelj G, Brvar M. Clin. Toxicol.,2017,55(3):193-195

    19. [19]

      Kevin R C, Lefever T W, Snyder R W, Patel P R, Fennell T R, Wiley J L, McGregor I S, Thomas B F. Forensic Toxicol.,2017,35(2):333-347

    20. [20]

      Longworth M, Banister S D, Boyd R, Kevin R C, Connor M, McGregor I S, Kassiou M. ACS Chem. Neurosci.,2017,8(10):2159-2167

    21. [21]

      Akiko A, Takahiro D, Takaomi T, Akihiro T, Yuka S, Masami K, Akihiko N, Yoshiyuki S. Forensic Toxicol.,2018,36(1):170-177

    22. [22]

      Staeheli S N, Poetzsch M, Veloso V P, Bovens M, Bissig C, Steuer A E, Kraemer T. Drug Test Anal.,2018,10(1):148-157

    23. [23]

      Ozturk Y E, Yeter O, Ozturk S, Karakus G, Ates I, Buyuk Y, Yurdun T. Drug Test Anal.,2018,10(3):449-459

    24. [24]

      QIAN Zhen-Hua, LIU Cui-Mei, HUA Zhen-Dong, GAO Li-Sheng. J. Chinese Mass Spectrom. Soc., 2018,39(3):323-330 钱振华, 刘翠梅, 花镇东, 高利生.质谱学报,2018,39(3):323-330

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  • 收稿日期:  2020-03-12
  • 修回日期:  2020-09-08
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