小分子靶标的核酸适配体筛选研究进展

王子健 陈尔凝 杨歌 赵新颖 屈锋

引用本文: 王子健,  陈尔凝,  杨歌,  赵新颖,  屈锋. 小分子靶标的核酸适配体筛选研究进展[J]. 分析化学, 2020, 48(5): 573-582. doi: 10.19756/j.issn.0253-3820.201101 shu
Citation:  WANG Zi-Jian,  CHEN Er-Ning,  YANG Ge,  ZHAO Xin-Ying,  QU Feng. Research Advances of Aptamers Selection for Small Molecule Targets[J]. Chinese Journal of Analytical Chemistry, 2020, 48(5): 573-582. doi: 10.19756/j.issn.0253-3820.201101 shu

小分子靶标的核酸适配体筛选研究进展

  • 基金项目:

    本文系国家自然科学基金项目(Nos.21675012,21274010,21874810)资助

摘要: 核酸适配体(Aptamer)作为新型识别分子,在小分子传感分析和检测中有很大的应用潜力。小分子的Aptamer筛选是其应用的前提。本文综述了2015~2019年,有关毒素、抗生素、激素等近80种小分子的Aptamer的筛选研究进展,归纳总结了近百条Aptamer序列和平衡解离常数KD及其测定方法,简要介绍了基于氧化石墨烯、人类基因组、石英晶体微天平以及计算机辅助筛选等改进型指数富集配体系统进化技术。

English


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  • 收稿日期:  2020-02-28
  • 修回日期:  2020-04-20
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