主客体作用在生化分析中的应用研究进展

崔琳 赵敏惠 张春阳

引用本文: 崔琳,  赵敏惠,  张春阳. 主客体作用在生化分析中的应用研究进展[J]. 分析化学, 2020, 48(7): 817-826. doi: 10.19756/j.issn.0253-3820.201090 shu
Citation:  CUI Lin,  ZHAO Min-Hui,  ZHANG Chun-Yang. Recent Advance in Applications of Host-Guest Interaction in Biochemical Analysis[J]. Chinese Journal of Analytical Chemistry, 2020, 48(7): 817-826. doi: 10.19756/j.issn.0253-3820.201090 shu

主客体作用在生化分析中的应用研究进展

  • 基金项目:

    本文系国家自然科学基金(Nos.21735003,21527811,21605096,21974080)和山东省泰山学者优势特色学科人才团队项目资助

摘要: 主客体作用是主体和客体在满足结构互补和能量匹配的条件下,通过非共价相互作用选择性结合,形成具有特定功能的超分子的过程。生物体系中的抗原-抗体、DNA-蛋白质、酶-底物等生物分子之间的识别都建立在非共价作用识别的基础上。主客体识别反应具有反应条件温和、反应过程动态可逆等特点,不仅可有效克服共价结合的局限性,而且能在分子水平上模拟生物功能。本文综述了主客体作用在生化分析中的应用的最新研究进展,并对基于主客体作用的传感器的发展趋势做了展望。

English


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  • 收稿日期:  2020-02-20
  • 修回日期:  2020-04-29
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