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蛋白质的核酸适配体筛选及应用的研究进展

赵丽萍 ,  杨歌 ,  张小敏 ,  屈锋

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引用本文: 赵丽萍,  杨歌,  张小敏,  屈锋. 蛋白质的核酸适配体筛选及应用的研究进展[J]. 分析化学, 2020, 48(5): 560-572. doi: 10.19756/j.issn.0253-3820.201024 shu
Citation:  ZHAO Li-Ping,  YANG Ge,  ZHANG Xiao-Min,  QU Feng. Development of Apatmer Screening Against Proteins and Its Applications[J]. Chinese Journal of Analytical Chemistry, 2020, 48(5): 560-572. doi: 10.19756/j.issn.0253-3820.201024 shu

蛋白质的核酸适配体筛选及应用的研究进展

  • 北京理工大学生命学院, "分子医学与生物诊疗"工业和信息化部重点实验室, 北京 100081

  • 基金项目:

    本文系国家自然科学基金项目（Nos.21675012，21874010，21827810）资助

摘要: 核酸适配体是通过指数富集配体系统进化（SELEX）筛选方法获得的，能够与靶标分子高亲和力和特异性结合的单链DNA或RNA。蛋白质是一种非常重要的生物功能大分子，迄今为止，已经开发了许多SELEX技术，用于蛋白质的适配体的筛选。目前，适配体的筛选优化方法主要集中在提高筛选效率、降低筛选成本，以及提升适配体性能等方面，从而获得可与靶标分子以高亲和力和高特异性结合的适配体。适配体与靶标分子亲和力的表征是关键的筛选步骤，用于判定所筛选的适配体是否可以满足后续应用需求。本文归纳总结了2016年以来蛋白质靶标的适配体筛选的研究进展，对核酸适配体筛选过程中有关核酸库的优化方法和筛选方法的改进、新筛选方法的开发、核酸适配体的应用等方面的研究进行了评述。

English


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