组织样品大气压质谱分析研究

引用本文: 王雨芬, 卢海艳, 张华, 陈焕文. 组织样品大气压质谱分析研究[J]. 分析化学, 2020, 48(7): 827-837. doi: 10.19756/j.issn.0253-3820.191704 shu

Citation: WANG Yu-Fen, LU Hai-Yan, ZHANG Hua, CHEN Huan-Wen. Research Progress on Tissue Analysis by Mass Spectrometry without Sample Pretreatment[J]. Chinese Journal of Analytical Chemistry, 2020, 48(7): 827-837. doi: 10.19756/j.issn.0253-3820.191704 shu

组织样品大气压质谱分析研究

1.
吉林大学无机合成与制备化学国家重点实验室, 长春 130012;
2.
东华理工大学江西省质谱科学与仪器重点实验室, 南昌 330013
基金项目:
本文系国家自然科学基金项目（Nos.21565004，21605016，21765001）和江西省自然科学基金项目（No.20171ACG70015）资助

摘要: 组织样品中含有丰富的生物分子信息，是代谢组学、脂质组学、蛋白质组学等研究的物质基础。近年来，大气压质谱分析（AMS）技术因具有无需样品预处理即可直接获取组织样品中生物分子种类及含量信息的能力，在组织样品分析中突显了高通量、高灵敏度、高准确性、低样品耗量的特点，已逐渐成为分析组织样品不可或缺的手段。本文以常见的植物、动物和临床术后组织样品为代表，介绍了近年来AMS技术在组织样品分析中的应用进展，结合成像技术，讨论了组织样品AMS的发展趋势。

关键词:

English

Research Progress on Tissue Analysis by Mass Spectrometry without Sample Pretreatment

1.
State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, Jilin University, Changchun 130012, China;
2.
Jiangxi Key Laboratory for Mass Spectrometry and Instrumentation, East China Institute of Technology, Nanchang 330013, China
Received Date: 30 November 2019
Revised Date: 10 January 2020
Fund Project:
This work was supported by the National Natural Science Foundation of China (Nos. 21565004, 21605016, 21765001) and the Natural Science Foundation of Jiangxi Province, China (No.20171ACG70015).

Abstract: Tissue samples contain abundant biological molecular information, which is widely used for the study of metabolomics, lipidomics and proteomics. Ambient mass spectrometry (AMS) has the ability to directly obtain the information of tissue samples, including the kind and content of biomolecules. Moreover, it has many advantages such as high sensitivity, high throughput, and low consumption, etc. Recently, AMS has been increasingly applied in analyzing various tissue samples. In this paper, the applications of AMS in plant, animal and postoperative tissue samples in recent years were reviewed. Furthermore, the challenges and prospects of analyzing tissue samples by ambient mass spectrometry imaging were briefly discussed.

Key words:

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1.
沈阳化工大学材料科学与工程学院沈阳 110142

组织样品大气压质谱分析研究

English

Research Progress on Tissue Analysis by Mass Spectrometry without Sample Pretreatment

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

组织样品大气压质谱分析研究

English

Research Progress on Tissue Analysis by Mass Spectrometry without Sample Pretreatment

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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